{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:11:52Z","timestamp":1777669912198,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.liebertpub.com\/nv\/resources-tools\/text-and-data-mining-policy\/121\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Gene Therapy"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1089\/hum.2016.184","type":"journal-article","created":{"date-parts":[[2017,5,6]],"date-time":"2017-05-06T04:34:38Z","timestamp":1494045278000},"page":"626-638","source":"Crossref","is-referenced-by-count":48,"title":["Prevention of Neurocognitive Deficiency in Mucopolysaccharidosis Type II Mice by Central Nervous System\u2013Directed, AAV9-Mediated Iduronate Sulfatase Gene Transfer"],"prefix":"10.1177","volume":"28","author":[{"given":"Kanut","family":"Laoharawee","sequence":"first","affiliation":[{"name":"Center for Genome Engineering, Department of Genetics Cell Biology and Development, University of Minnesota, Minneapolis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly M.","family":"Podetz-Pedersen","sequence":"additional","affiliation":[{"name":"Center for Genome Engineering, Department of Genetics Cell Biology and Development, University of Minnesota, Minneapolis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tam T.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Center for Genome Engineering, Department of Genetics Cell Biology and Development, University of Minnesota, Minneapolis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura B.","family":"Evenstar","sequence":"additional","affiliation":[{"name":"Center for Genome Engineering, Department of Genetics Cell Biology and Development, University of Minnesota, Minneapolis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelley F.","family":"Kitto","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and College of Pharmacy, University of Minnesota, Minneapolis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenhong","family":"Nan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Minnesota, Minneapolis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn A.","family":"Fairbanks","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and College of Pharmacy, University of Minnesota, Minneapolis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter C.","family":"Low","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Minnesota, Minneapolis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen F.","family":"Kozarsky","sequence":"additional","affiliation":[{"name":"REGENXBIO, Inc., Rockville, Maryland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Scott","family":"McIvor","sequence":"additional","affiliation":[{"name":"Center for Genome Engineering, Department of Genetics Cell Biology and Development, University of Minnesota, Minneapolis"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320460222"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)70202-0"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005525931994"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)92597-X"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2009.87"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.1028"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2010.249"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-0016(03)00168-0"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2014.09.011"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201202287"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2012.09.004"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002865"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1407309"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2009.71"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1515"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/mtm.2014.32"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2014.00042"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2010.055"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-6-31"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000000157"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.02.015"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1037\/h0077579"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-015-0244-7"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-0016(16)35623-4"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.86696"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2016.101"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm223"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2013.09.008"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1172\/JCI66778"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.07.011"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-090711-163739"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1203\/01.pdr.0000233037.00707.da"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2011.34"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3581-04.2004"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(01)00515-7"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.1092"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1101\/lm.334306"}],"container-title":["Human Gene Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.liebertpub.com\/doi\/full-xml\/10.1089\/hum.2016.184","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.liebertpub.com\/doi\/pdf\/10.1089\/hum.2016.184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:54:10Z","timestamp":1777449250000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/hum.2016.184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1089\/hum.2016.184"],"URL":"https:\/\/doi.org\/10.1089\/hum.2016.184","relation":{},"ISSN":["1043-0342","1557-7422"],"issn-type":[{"value":"1043-0342","type":"print"},{"value":"1557-7422","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8]]}}}