{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:05:38Z","timestamp":1791198338201,"version":"4.1.0"},"reference-count":176,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Human Gene Therapy"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>\n                    The infusion of healthy stem cells into a patient\u2014termed \u201cstem-cell therapy\u201d\u2014has shown great promise for the treatment of genetic and non-genetic diseases, including mucopolysaccharidosis type 1, Parkinson's disease, multiple sclerosis, numerous immunodeficiency disorders, and aplastic anemia. Stem cells for cell therapy can be collected from the patient (autologous) or collected from another \u201chealthy\u201d individual (allogeneic). The use of allogenic stem cells is accompanied with the potentially fatal risk that the transplanted donor T cells will reject the patient's cells\u2014a process termed \u201cgraft-versus-host disease.\u201d Therefore, the use of autologous stem cells is preferred, at least from the immunological perspective. However, an obvious drawback is that inherently as \u201cself,\u201d they contain the disease mutation. As such, autologous cells for use in cell therapies often require genetic \u201ccorrection\u201d (\n                    <jats:italic toggle=\"yes\">i.e.<\/jats:italic>\n                    , gene addition or editing) prior to cell infusion and therefore the requirement for some form of nucleic acid delivery, which sets the stage for the AAV controversy discussed herein. Despite being the most clinically applied gene delivery context to date, unlike other more concerning integrating and non-integrating vectors such as retroviruses and adenovirus, those based on adeno-associated virus (AAV) have not been employed in the clinic. Furthermore, published data regarding AAV vector transduction of stem cells are inconsistent in regards to vector transduction efficiency, while the pendulum swings far in the other direction with demonstrations of AAV vector\u2013induced toxicity in undifferentiated cells. The variation present in the literature examining the transduction efficiency of AAV vectors in stem cells may be due to numerous factors, including inconsistencies in stem-cell collection, cell culture, vector preparation, and\/or transduction conditions. This review summarizes the controversy surrounding AAV vector transduction of stem cells, hopefully setting the stage for future elucidation and eventual therapeutic applications.\n                  <\/jats:p>","DOI":"10.1089\/hum.2017.038","type":"journal-article","created":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T08:14:55Z","timestamp":1494490495000},"page":"450-463","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":42,"title":["Adeno-Associated Virus Vectors and Stem Cells: Friends or Foes?"],"prefix":"10.1177","volume":"28","author":[{"given":"Nolan","family":"Brown","sequence":"first","affiliation":[{"name":"University of North Carolina at Chapel Hill"},{"name":"University of North Carolina at Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liujiang","family":"Song","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill"},{"name":"University of North Carolina at Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nageswara R.","family":"Kollu","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill"},{"name":"University of North Carolina at Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L.","family":"Hirsch","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill"},{"name":"University of North Carolina at Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,6,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1599"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027520"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-75-10-2655"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.35.1.71-78.1997"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-virology-031413-085355"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.162250899"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.15.9933-9944.2005"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-2-43"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.2174\/1566523054065057"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.2174\/1566523054064968"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.6.2077"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.63.9.3822-3828.1989"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.10.4612-4620.2000"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302133"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3301514"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2014.3003"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0498-325"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2011.301"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-761-7_19"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2011.255"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2010.55"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.08.075"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.70.11.8098-8108.1996"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704081"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-10-74"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.3109\/14653240903348293"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.11.8262-8267.1997"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/4758"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/6185"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-81-8-2077"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2010.005"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2006.15.87"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302102"},{"key":"e_1_3_3_35_2","first-page":"196","article-title":"Effect of hydroxyurea and etoposide on transduction of human bone marrow mesenchymal stem and progenitor cell by adeno-associated virus vectors","volume":"25","author":"Ju X","year":"2004","unstructured":"Ju X, , Lou S, , Wang W, et al. 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