{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:21:55Z","timestamp":1791300115525,"version":"4.1.0"},"reference-count":86,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.liebertpub.com\/nv\/resources-tools\/text-and-data-mining-policy\/121\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Gene Therapy"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1089\/hum.2017.072","type":"journal-article","created":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T02:08:20Z","timestamp":1503367700000},"page":"352-365","source":"Crossref","is-referenced-by-count":21,"title":["Gene Therapy with an Adeno-Associated Viral Vector Expressing Human Interleukin-2 Alters Immune System Homeostasis in Humanized Mice"],"prefix":"10.1177","volume":"29","author":[{"given":"Philip A.","family":"Durost","sequence":"first","affiliation":[{"name":"Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-Edwin","family":"Aryee","sequence":"additional","affiliation":[{"name":"Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Manzoor","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland M.","family":"Tisch","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Horae Gene Therapy Center, University of Massachusetts Medical School, Worcester, Massachusetts."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Jurczyk","sequence":"additional","affiliation":[{"name":"Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard D.","family":"Shultz","sequence":"additional","affiliation":[{"name":"Jackson Laboratory, Bar Harbor, Maine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Brehm","sequence":"additional","affiliation":[{"name":"Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2008.68"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-virology-031413-085355"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3742"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2016.07.006"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-bioeng-071813-104938"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2016.160"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7246"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1510604112"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.08.104"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00259-16"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.08.006"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2015.09.005"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088205"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/83784"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.10.007"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/83707"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1213"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001422"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0669"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002139"},{"key":"B21","first-page":"651","volume":"6","author":"Pham MN","year":"2015","journal-title":"Front Immunol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020190"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2014.45"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2014.02.003"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100209"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1108188"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105143"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2014.504"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4148"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206506"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0049"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(13)70113-X"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.2337\/db14-1322"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2015.01.001"},{"key":"B35","first-page":"149","volume":"324","author":"Wege AK","year":"2008","journal-title":"Curr Top Microbiol Immunol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-1133-2_18"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12180"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2013.065"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3301514"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.207"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61737-979-6_15"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-06-027409"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007980"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2016.84"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.115212"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-052016-100332"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/nri3311"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2013.02.005"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12180"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-10-3697"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1038\/nm1431"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2001-12-0207"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.10.6477"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/nri2580"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1126\/science.1093933"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-11-570218"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2009.12.008"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2009.06.005"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-02-271841"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/ni1527"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2011.05.013"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-8-65"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2011.03501.x"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2013.03.009"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2014.02.011"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.cimid.2016.08.006"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2012.2"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003481"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv538"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100394"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00623"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0049"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit319"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401323"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14116"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051832"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-16-0159"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.11.040193.001333"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1038\/nri3156"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.01.004"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.89278"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1038\/srep40623"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1126\/science.1122927"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1038\/nature10975"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1222878110"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.5.2731"}],"container-title":["Human Gene Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.liebertpub.com\/doi\/full-xml\/10.1089\/hum.2017.072","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.liebertpub.com\/doi\/pdf\/10.1089\/hum.2017.072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:54:27Z","timestamp":1777449267000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/hum.2017.072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":86,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1089\/hum.2017.072"],"URL":"https:\/\/doi.org\/10.1089\/hum.2017.072","relation":{},"ISSN":["1043-0342","1557-7422"],"issn-type":[{"value":"1043-0342","type":"print"},{"value":"1557-7422","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3]]}}}