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However, treatment with monoclonal antibodies has not been enough to overcome the refractory\/relapse problems. Chimeric antigen receptor engineered T (CAR-T) cells have exhibited excellent therapeutic effect on lymphocytic leukemia in recent years. In this study, a CD20-specific CAR was constructed and the cytotoxic efficacy of CD20 CAR-T cells on B-cell malignant cells was evaluated by CD107a degranulation, pro-inflammation cytokine production, and true lytic ability\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    . It was found that CD20 CAR-T cells possessed stronger cytotoxic ability against CD20 highly expressed cells. Furthermore, when histone deacetylase inhibitor was used to enhance the expression of CD20 antigen on the surface of B-cell malignant cells via inducing acetylation of H3K9 on CD20 promoter site, it revealed that the cytotoxicity of CD20 CAR-T cells against histone deacetylase inhibitor\u2013treated B-cell malignant cells was significantly enhanced.\n                  <\/jats:p>","DOI":"10.1089\/hum.2018.119","type":"journal-article","created":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T08:07:55Z","timestamp":1541059675000},"page":"497-510","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Induced CD20 Expression on B-Cell Malignant Cells Heightened the Cytotoxic Activity of Chimeric Antigen Receptor Engineered T Cells"],"prefix":"10.1177","volume":"30","author":[{"given":"Yingxi","family":"Xu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, Institute of 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