{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:20:51Z","timestamp":1790256051396,"version":"4.1.0"},"reference-count":58,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.liebertpub.com\/nv\/resources-tools\/text-and-data-mining-policy\/121\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Gene Therapy"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1089\/hum.2018.205","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T04:34:42Z","timestamp":1551242082000},"page":"865-881","source":"Crossref","is-referenced-by-count":49,"title":["Dysregulated Expression of microRNA-21 and Disease-Related Genes in Human Patients and in a Mouse Model of Alport Syndrome"],"prefix":"10.1177","volume":"30","author":[{"given":"Jifan","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Peking University First Hospital, Beijing, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenping","family":"Song","sequence":"additional","affiliation":[{"name":"Rare Disease Research, Sanofi Genzyme, Framingham, Massachusetts."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Boulanger","sequence":"additional","affiliation":[{"name":"Rare Disease Research, Sanofi Genzyme, Framingham, Massachusetts."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan Y.","family":"Xu","sequence":"additional","affiliation":[{"name":"Translational Sciences, Sanofi Genzyme, Framingham, Massachusetts."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Peking University First Hospital, Beijing, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Peking University First Hospital, Beijing, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"He","sequence":"additional","affiliation":[{"name":"Department of Urology, Peking University First Hospital, Beijing, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suxia","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Electron Microscopy, Peking University First Hospital, Beijing, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Pryce","sequence":"additional","affiliation":[{"name":"Rare Disease Research, Sanofi Genzyme, Framingham, Massachusetts."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Phillips","sequence":"additional","affiliation":[{"name":"Rare Disease Research, Sanofi Genzyme, Framingham, Massachusetts."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deidre","family":"MacKenna","sequence":"additional","affiliation":[{"name":"Regulus Therapeutics, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekkehard","family":"Leberer","sequence":"additional","affiliation":[{"name":"R&D Alliance Management, Sanofi, Frankfurt, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oxana","family":"Ibraghimov-Beskrovnaya","sequence":"additional","affiliation":[{"name":"Rare Disease Research, Sanofi Genzyme, Framingham, Massachusetts."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Peking University First Hospital, Beijing, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiguang","family":"Liu","sequence":"additional","affiliation":[{"name":"Rare Disease Research, Sanofi Genzyme, Framingham, Massachusetts."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.9636.1"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra022296"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2012.259"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.23.2981"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.5527\/wjn.v3.i4.230"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.407"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-017-2639-3"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.4103\/2229-3485.179431"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.246"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1177\/0300985818806050"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015060634"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2804-x"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037366"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2012.02.003"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2013.1460"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1172\/JCI75852"},{"key":"B18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/kisup.2012.73","volume":"3","author":"Kidney Disease Improving Global Outcomes CKD Working Group","year":"2013","journal-title":"Kidney Int"},{"key":"B19","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1681\/ASN.V10122591","volume":"10","author":"Remuzzi G","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1226"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00556.x"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2016.08.001"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu028"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003205"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.trre.2011.10.002"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-016-3383-8"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e328336ebb0"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013121274"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8319283"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058014"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0912701107"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00273.2011"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/srep27209"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aac7071"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1007\/BF00266763"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1007\/BF01600241"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/msb4100014"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1159\/000452595"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-018-3988-1"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2016.10.64"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.01.015"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.435"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2010.486496"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2010.10.005"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/465897"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2011.09.004"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000133604.20182.cf"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.2174\/13816128113199990547"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M806920200"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-0639"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.5732\/cjc.30.0371"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-016-0309-5"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1159\/000368940"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2009.08.024"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2017.11.010"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2013.01.003"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1080\/00365510802145059"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1002\/path.2175"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013070758"}],"container-title":["Human Gene Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.liebertpub.com\/doi\/full-xml\/10.1089\/hum.2018.205","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.liebertpub.com\/doi\/pdf\/10.1089\/hum.2018.205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:55:01Z","timestamp":1777449301000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/hum.2018.205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":58,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1089\/hum.2018.205"],"URL":"https:\/\/doi.org\/10.1089\/hum.2018.205","relation":{},"ISSN":["1043-0342","1557-7422"],"issn-type":[{"value":"1043-0342","type":"print"},{"value":"1557-7422","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7]]}}}