{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:09:52Z","timestamp":1787008192454,"version":"build-2736575974"},"reference-count":31,"publisher":"SAGE Publications","issue":"1-2","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.liebertpub.com\/nv\/resources-tools\/text-and-data-mining-policy\/121\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Gene Therapy"],"published-print":{"date-parts":[[2020,1,1]]},"DOI":"10.1089\/hum.2019.233","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T07:27:59Z","timestamp":1571988479000},"page":"70-79","source":"Crossref","is-referenced-by-count":7,"title":["Systemic Safety of a Recombinant AAV8 Vector for Human Cocaine Hydrolase Gene Therapy: A Good Laboratory Practice Preclinical Study in Mice"],"prefix":"10.1177","volume":"31","author":[{"given":"Vicky Ping","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyi","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Steele","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Jenks","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kah-Whye","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Brimijoin","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.56.6.507"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.128"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.2174\/1874473711003010049"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(97)00119-1"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.66.3.904-908.2000"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.068122"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301666"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.150029"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20130549"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2008.76"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2010.02.036"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067446"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-015-0175-9"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/nature10660"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1021\/ja803646t"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-2697(02)00238-5"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2009.246"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90331-3"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/s40259-017-0234-5"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2954"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12478"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1517\/21678707.2015.1039511"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2014.05.067"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-013-0130-5"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2012.08.006"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.115.228825"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2008.04.024"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.450"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2016.07.006"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1407309"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1108046"}],"container-title":["Human Gene Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.liebertpub.com\/doi\/full-xml\/10.1089\/hum.2019.233","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.liebertpub.com\/doi\/pdf\/10.1089\/hum.2019.233","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:55:08Z","timestamp":1777449308000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/hum.2019.233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,1]]},"references-count":31,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2020,1,1]]}},"alternative-id":["10.1089\/hum.2019.233"],"URL":"https:\/\/doi.org\/10.1089\/hum.2019.233","relation":{},"ISSN":["1043-0342","1557-7422"],"issn-type":[{"value":"1043-0342","type":"print"},{"value":"1557-7422","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,1]]}}}