{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:15:28Z","timestamp":1777670128960,"version":"3.51.4"},"reference-count":105,"publisher":"SAGE Publications","issue":"3-4","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.liebertpub.com\/nv\/resources-tools\/text-and-data-mining-policy\/121\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Gene Therapy"],"published-print":{"date-parts":[[2020,2,1]]},"DOI":"10.1089\/hum.2019.268","type":"journal-article","created":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T05:00:56Z","timestamp":1575522056000},"page":"163-182","source":"Crossref","is-referenced-by-count":9,"title":["Systemic Adeno-Associated Virus-Mediated Gene Therapy Prevents the Multiorgan Disorders Associated with Aldehyde Dehydrogenase 2 Deficiency and Chronic Ethanol Ingestion"],"prefix":"10.1177","volume":"31","author":[{"given":"Yuki","family":"Matsumura","sequence":"first","affiliation":[{"name":"Department of Genetic Medicine, Weill Cornell Medical College, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanan","family":"Alwaseem","sequence":"additional","affiliation":[{"name":"Proteomics Resource Center, The Rockefeller University, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Odelya E.","family":"Pagovich","sequence":"additional","affiliation":[{"name":"Department of Genetic Medicine, Weill Cornell Medical College, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald G.","family":"Crystal","sequence":"additional","affiliation":[{"name":"Department of Genetic Medicine, Weill Cornell Medical College, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew B.","family":"Greenblatt","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York"},{"name":"Research Division, Hospital for Special Surgery, New York, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie M.","family":"Stiles","sequence":"additional","affiliation":[{"name":"Department of Genetic Medicine, Weill Cornell Medical College, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000050"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00017.2013"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010814-124915"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.1998.2510549.x"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1996.tb01091.x"},{"key":"B6","first-page":"42","volume":"44","author":"Stewart MJ","year":"1996","journal-title":"J Investig Med"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1021\/bi9521093"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq192"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1510757112"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-2797(00)00221-0"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M607959200"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01710-5"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12215"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2008.12.021"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e3282609e67"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2008.00807.x"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0435"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1997.12.7.998"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1999.tb04126.x"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1634"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1734-y"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-007-0543-5"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00503-2"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-006-0077-2"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009539"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgm057"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/srep14142"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.2131\/jts.30.315"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.2741\/2198"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2019.08.004"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2005.09.003"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mt.6300344"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2011.01612.x"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(99)00010-X"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2005.04.013"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12462"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2019.01.035"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0117"},{"key":"B40","first-page":"305","volume":"22","author":"Kuo LJ","year":"2008","journal-title":"In Vivo"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2011.01.008"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42285"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-013-9809-4"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24357"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-010-0056-7"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.2131\/jts.32.421"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/ng.834"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-10-0774"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(86)90201-5"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198609000-00005"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyw208"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000085589.47243.8D"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/nature11368"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/nature25154"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-06-507962"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2016.07.004"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.2923"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.12.006"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.4238\/gmr.15038606"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/srep30424"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031522"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2010.03.024"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-005-1610-3"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgz091"},{"key":"B65","first-page":"37","volume":"8","author":"Tetreault MP","year":"2015","journal-title":"Cancer Growth Metastasis"},{"key":"B66","first-page":"279","volume":"4","author":"Yukawa Y","year":"2014","journal-title":"Am J Cancer Res"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04926.x"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70326-2"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgs340"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2006.12.002"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-010-0057-6"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1021\/ja2004686"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2797(95)03632-V"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1021\/tx060113h"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glt093"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3666"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(02)00059-X"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/ags135"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(90)90071-6"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(91)90044-W"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/gew016"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2000.tb02068.x"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2001.tb02286.x"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074418"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2016.12.013"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91629-2"},{"key":"B89","first-page":"17","volume":"38","author":"Iwamoto DK","year":"2016","journal-title":"Alcohol Res"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/23.11.1851"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.110.1.173"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-017-0327-y"},{"key":"B93","first-page":"5","volume":"30","author":"Edenberg HJ","year":"2007","journal-title":"Alcohol Res Health"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e32832ecf2e"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.7.817"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1080\/23311908.2016.1149264"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1016\/0741-8329(85)90077-1"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)90955-2"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(01)00733-X"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2003.09.013"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-004-1911-x"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2005.03.003"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-015-4049-0"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12130"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1021\/tx2005184"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(91)90192-6"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.06.012"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201100148"}],"container-title":["Human Gene Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.liebertpub.com\/doi\/full-xml\/10.1089\/hum.2019.268","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.liebertpub.com\/doi\/pdf\/10.1089\/hum.2019.268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:55:26Z","timestamp":1777449326000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/hum.2019.268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,1]]},"references-count":105,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2020,2,1]]}},"alternative-id":["10.1089\/hum.2019.268"],"URL":"https:\/\/doi.org\/10.1089\/hum.2019.268","relation":{},"ISSN":["1043-0342","1557-7422"],"issn-type":[{"value":"1043-0342","type":"print"},{"value":"1557-7422","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,1]]}}}