{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:51:17Z","timestamp":1792144277362,"version":"4.4.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"23-24","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Human Gene Therapy"],"published-print":{"date-parts":[[2020,12]]},"abstract":"\n Long-noncoding RNA<\/jats:italic>\n taurine upregulated gene 1 (\n TUG1<\/jats:italic>\n ) participates in nervous system diseases, but its function in Parkinson's disease (PD) remains unclear. This study explored the function and mechanism of\n TUG1<\/jats:italic>\n in PD. A PD model was constructed using SH-SY5Y cells induced by 1-methyl-4-phenylpyridinium (MPP\n +<\/jats:sup>\n )\n in vitro<\/jats:italic>\n and mice treated by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)\n in vivo<\/jats:italic>\n . The expressions of\n TUG1<\/jats:italic>\n ,\n miR-152-3p<\/jats:italic>\n , phosphatase and tensin homologue (\n PTEN<\/jats:italic>\n ), tyrosine hydroxylase (TH), and Bcl-2, and cleaved caspase-3 expressions were determined by quantitative reverse transcription-PCR and Western blotting. The viability, apoptosis, reactive oxygen species, and release of inflammatory factors from SH-SY5Y cells and substantia nigra tissues were detected by commercial kits. The interaction between\n TUG1<\/jats:italic>\n and\n miR-152-3p<\/jats:italic>\n was analyzed by dual-luciferase reporter assay. Hematoxylin\/eosin and immunohistochemical staining was performed for assessing the pathological damage and proportion of TH-positive cells. In PD cell model and mice model,\n TUG1<\/jats:italic>\n expression was upregulated and that of\n miR-152-3p<\/jats:italic>\n was downregulated. Further research showed that\n TUG1<\/jats:italic>\n sponged and regulated\n miR-152-3p<\/jats:italic>\n expression. Silencing of\n TUG1<\/jats:italic>\n not only protected SH-SY5Y cells against cell apoptosis, oxidative stress, and neuroinflammation\n in vitro<\/jats:italic>\n , pathological damage and neuroinflammation\n in vivo<\/jats:italic>\n , but also suppressed the expressions of\n PTEN<\/jats:italic>\n and cleaved caspase-3, and increased the expressions of TH and Bcl-2 in MPP\n +<\/jats:sup>\n -treated SH-SY5Y cells. However, the protective role of siTUG1 in SH-SY5Y cells was significantly inhibited by the\n miR-152-3p<\/jats:italic>\n inhibitor. Thus, knocking down\n TUG1<\/jats:italic>\n might have a protective effect on PD through the\n miR-152-3p\/PTEN<\/jats:italic>\n pathway.\n <\/jats:p>","DOI":"10.1089\/hum.2020.106","type":"journal-article","created":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T05:19:06Z","timestamp":1597727946000},"page":"1274-1287","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":37,"title":["Long-Noncoding RNA TUG1<\/i>\n Promotes Parkinson's Disease via Modulating\n MiR-152-3p\/PTEN<\/i>\n Pathway"],"prefix":"10.1177","volume":"31","author":[{"given":"Kaihua","family":"Zhai","sequence":"first","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrine, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,12,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61393-3"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2017.62"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.11.018"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825666190111150953"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.06.012"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2017.12.011"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000251963"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.1471"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-017-0147-5"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.15511"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.12.006"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2019.00215"},{"key":"e_1_3_3_14_2","first-page":"7393","article-title":"Overexpression of TUG1 promotes neuronal death after cerebral infarction by regulating microRNA-9","volume":"22","author":"Xiong ZJ","year":"2018","unstructured":"Xiong ZJ, , Zhang Q, , Wang DX, et al. 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