{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:16:13Z","timestamp":1777670173523,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"23-24","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Human Gene Therapy"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:p>Cardiomyocyte apoptosis is a characteristic of a variety of cardiac diseases, including myocardial infarction (MI). Kr\u00fcppel-like factor 15 (KLF15) is a transcription factor of Kr\u00fcppel family that plays an important part in cardiovascular diseases. However, the function and the underlying mechanism of KLF15 in MI remain unknown. The expression of KLF15 was downregulated both in ischemic myocardium of MI mice model and hypoxia-treated neonatal rat ventricular myocytes (NRVCs). KLF15 overexpression mediated by adeno-associated virus significantly abrogated the ischemia-induced cardiac dysfunction, increased the survival rate, and reduced infarct size after MI. Meanwhile, KLF15 overexpression dramatically reduced the myocardial apoptosis, regulated apoptosis-related genes, such as Bcl2 and Bax, diminished the activities of caspase-9\/3, and inactivated p38\/MAPK signaling in the border zone. Similar results were observed in NRVCs exposed to hypoxia. We demonstrated for the first time that KLF15 overexpression could reduce cardiomyocyte apoptosis and improve cardiac dysfunction in MI mice at least partially by inhibiting p38\/MAPK signaling pathway.<\/jats:p>","DOI":"10.1089\/hum.2021.075","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T13:05:54Z","timestamp":1627391154000},"page":"1471-1480","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Kr\u00fcppel-Like Factor 15 Reduces Ischemia-Induced Apoptosis Involving Regulation of p38\/MAPK Signaling"],"prefix":"10.1177","volume":"32","author":[{"given":"Bo","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Traditional Chinese Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haijia","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Weihai Central Hospital, Weihai, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Kong","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deshan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weidong","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4089-1325","authenticated-orcid":false,"given":"Wenwu","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,12,16]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000950"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn243"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00022.2018"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2014.11.006"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.19.7319-7331.2000"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0701981104"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2008.05.005"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3000502"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20200075"},{"key":"e_1_3_5_11_2","first-page":"10819","article-title":"KLF15 reduces the level of apoptosis in mouse liver induced by sepsis by inhibiting p38MAPK\/ERK1\/2 signaling pathway","volume":"24","author":"Tian LL","year":"2020","unstructured":"Tian LL, , Zhang J, , Wang ZZ, et al. 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