{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:20:04Z","timestamp":1777670404892,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"17-18","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.liebertpub.com\/nv\/resources-tools\/text-and-data-mining-policy\/121\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Gene Therapy"],"published-print":{"date-parts":[[2023,9,1]]},"DOI":"10.1089\/hum.2023.011","type":"journal-article","created":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T03:32:58Z","timestamp":1687491178000},"page":"917-926","source":"Crossref","is-referenced-by-count":4,"title":["Recapitulation of Skewed X-Inactivation in Female Ornithine Transcarbamylase-Deficient Primary Human Hepatocytes in the FRG Mouse: A Novel System for Developing Epigenetic Therapies"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6335-9104","authenticated-orcid":false,"given":"Sharon C.","family":"Cunningham","sequence":"first","affiliation":[{"name":"Gene Therapy Research Unit, Faculty of Medicine and Health, Children's Medical Research Institute, The University of Sydney and Sydney Children's Hospitals Network, Westmead, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva B.","family":"van Dijk","sequence":"additional","affiliation":[{"name":"Gene Therapy Research Unit, Faculty of Medicine and Health, Children's Medical Research Institute, The University of Sydney and Sydney Children's Hospitals Network, Westmead, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erhua","family":"Zhu","sequence":"additional","affiliation":[{"name":"Gene Therapy Research Unit, Faculty of Medicine and Health, Children's Medical Research Institute, The University of Sydney and Sydney Children's Hospitals Network, Westmead, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maya","family":"Sugden","sequence":"additional","affiliation":[{"name":"Gene Therapy Research Unit, Faculty of Medicine and Health, Children's Medical Research Institute, The University of Sydney and Sydney Children's Hospitals Network, Westmead, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mawj","family":"Mandwie","sequence":"additional","affiliation":[{"name":"Gene Therapy Research Unit, Faculty of Medicine and Health, Children's Medical Research Institute, The University of Sydney and Sydney Children's Hospitals Network, Westmead, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Siew","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, James Fairfax Institute of Paediatric Nutrition, Sydney Children's Hospitals Network, Westmead, Australia."},{"name":"Discipline of Child and Adolescent Health, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beena","family":"Devanapalli","sequence":"additional","affiliation":[{"name":"NSW Biochemical Genetics Service, The Children's Hospital at Westmead, Westmead, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adviye Ayper","family":"Tolun","sequence":"additional","affiliation":[{"name":"Discipline of Child and Adolescent Health, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia."},{"name":"NSW Biochemical Genetics Service, The Children's Hospital at Westmead, Westmead, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Klein","sequence":"additional","affiliation":[{"name":"Australian e-Health Research Centre, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Sydney, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Wilson","sequence":"additional","affiliation":[{"name":"Australian e-Health Research Centre, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Sydney, Australia."},{"name":"Department of Biomedical Sciences, Macquarie University, Macquarie Park, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nader","family":"Aryamanesh","sequence":"additional","affiliation":[{"name":"Embryology Research Unit, Bioinformatics Group, Children's Medical Research Institute, University of Sydney, Westmead, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Gissen","sequence":"additional","affiliation":[{"name":"National Institute for Health Research Great Ormond Street Hospital Biomedical Research Centre, University College London, London, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Baruteau","sequence":"additional","affiliation":[{"name":"National Institute for Health Research Great Ormond Street Hospital Biomedical Research Centre, University College London, London, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaustuv","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Discipline of Child and Adolescent Health, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia."},{"name":"Genetic Metabolic Disorders Service, The Children's Hospital at Westmead, Sydney, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian E.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Gene Therapy Research Unit, Faculty of Medicine and Health, Children's Medical Research Institute, The University of Sydney and Sydney Children's Hospitals Network, Westmead, Australia."},{"name":"Discipline of Child and Adolescent Health, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/190372a0"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-020-0779-4"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1715124115"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.01.012"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz1214"},{"issue":"10","key":"B6","first-page":"1420","volume":"97","author":"Summar ML","year":"2008","journal-title":"Acta Paediatr Oslo Nor 1992"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1326"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/nature12875"},{"issue":"79","key":"B9","first-page":"50615","author":"Lee SML","year":"2013","journal-title":"J Vis Exp"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.7.3639"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aba3312"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/humu.1380110103"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-020-00620-7"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2020.06.003"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2021.278"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2019.264"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2021.11.011"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2017.09.021"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/s41434-019-0104-5"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2018.10.016"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2020.05.004"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32733"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2019.100065"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22932-4"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c10631"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1007\/s11248-018-0096-8"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-083117-021632"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1685"}],"container-title":["Human Gene Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.liebertpub.com\/doi\/full-xml\/10.1089\/hum.2023.011","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.liebertpub.com\/doi\/pdf\/10.1089\/hum.2023.011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:56:40Z","timestamp":1777449400000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/hum.2023.011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,1]]},"references-count":29,"journal-issue":{"issue":"17-18","published-print":{"date-parts":[[2023,9,1]]}},"alternative-id":["10.1089\/hum.2023.011"],"URL":"https:\/\/doi.org\/10.1089\/hum.2023.011","relation":{},"ISSN":["1043-0342","1557-7422"],"issn-type":[{"value":"1043-0342","type":"print"},{"value":"1557-7422","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,1]]}}}