{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:55:49Z","timestamp":1782741349433,"version":"3.54.5"},"reference-count":29,"publisher":"SAGE Publications","issue":"19-20","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.liebertpub.com\/nv\/resources-tools\/text-and-data-mining-policy\/121\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Gene Therapy"],"published-print":{"date-parts":[[2023,10,1]]},"DOI":"10.1089\/hum.2023.092","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T07:42:37Z","timestamp":1691998957000},"page":"1049-1063","source":"Crossref","is-referenced-by-count":6,"title":["Developing a Gene Therapy for the Treatment of Autosomal Dominant Alzheimer's Disease"],"prefix":"10.1177","volume":"34","author":[{"given":"Benjamin","family":"Moore","sequence":"first","affiliation":[{"name":"Paros Bio, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apurwa","family":"Sharma","sequence":"additional","affiliation":[{"name":"Paros Bio, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Goulet","sequence":"additional","affiliation":[{"name":"Paros Bio, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7091-2297","authenticated-orcid":false,"given":"Tracey","family":"Suter","sequence":"additional","affiliation":[{"name":"Paros Bio, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Pelletier","sequence":"additional","affiliation":[{"name":"Paros Bio, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoxi","family":"Hu","sequence":"additional","affiliation":[{"name":"Paros Bio, Boston, Massachusetts, USA."},{"name":"Mass General Brigham Ventures (Partners Innovation Fund), Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3892-6163","authenticated-orcid":false,"given":"Eric","family":"Schaeffer","sequence":"additional","affiliation":[{"name":"Paros Bio, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Raymond J.","family":"Kelleher","sequence":"additional","affiliation":[{"name":"Department of Neurology, and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA."},{"name":"Program in Neuroscience, Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.09.001"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-014-0499-8"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608332104"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.116962"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0954-13.2013"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.02.010"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.03.009"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1618657114"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/s0896-6273(04)00182-5"},{"key":"B11","unstructured":"11. Franklin KBJ, Paxinos G. The Mouse Brain in Stereotaxic Coordinates. Elsevier B.V: Amsterdam, Netherlands; 1997."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1186\/s12868-021-00637-0"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1006\/mthe.2001.0415"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M409544200"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2004.12.012"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010195"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1202753"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2018.07.008"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0311-9"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00813-8"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2022.30"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2015.10.006"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1304171110"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/nature08177"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1619574114"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1317918110"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1089\/humc.2017.231"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2020.167"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2020.12.006"}],"container-title":["Human Gene Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.liebertpub.com\/doi\/full-xml\/10.1089\/hum.2023.092","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.liebertpub.com\/doi\/pdf\/10.1089\/hum.2023.092","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:56:44Z","timestamp":1777449404000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/hum.2023.092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,1]]},"references-count":29,"journal-issue":{"issue":"19-20","published-print":{"date-parts":[[2023,10,1]]}},"alternative-id":["10.1089\/hum.2023.092"],"URL":"https:\/\/doi.org\/10.1089\/hum.2023.092","relation":{},"ISSN":["1043-0342","1557-7422"],"issn-type":[{"value":"1043-0342","type":"print"},{"value":"1557-7422","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,1]]}}}