{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T19:30:48Z","timestamp":1793302248179,"version":"4.5.0"},"reference-count":114,"publisher":"SAGE Publications","issue":"9-10","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.liebertpub.com\/nv\/resources-tools\/text-and-data-mining-policy\/121\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Gene Therapy"],"published-print":{"date-parts":[[2024,5,1]]},"DOI":"10.1089\/hum.2024.022","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T09:18:40Z","timestamp":1711531120000},"page":"317-328","source":"Crossref","is-referenced-by-count":26,"title":["Development of AAV-Mediated Gene Therapy Approaches to Treat Skeletal Diseases"],"prefix":"10.1177","volume":"35","author":[{"given":"Chujiao","family":"Lin","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew B.","family":"Greenblatt","sequence":"additional","affiliation":[{"name":"Research Division, Hospital for Special Surgery, New York, New York, USA"},{"name":"Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangping","family":"Gao","sequence":"additional","affiliation":[{"name":"Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA"},{"name":"Department of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA"},{"name":"Viral Vector Core, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA"},{"name":"Li Weibo Institute for Rare Diseases Research, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4947-3293","authenticated-orcid":false,"given":"Jae-Hyuck","family":"Shim","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA"},{"name":"Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA"},{"name":"Li Weibo Institute for Rare Diseases Research, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.5152\/eurjrheum.2016.048"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.2174\/1871520615666150325232857"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1177\/2042098614548680"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.11136"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2019-00221"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.2.348"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00511"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0809493"},{"key":"B9","volume-title":"Adverse effects of bisphosphonates: implications for osteoporosis management","author":"Kennel KA","year":"2009"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2013.03.002"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1768"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.173"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2015.03.016"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20868"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199302000-00008"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1126\/science.175.4025.949"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1089\/dna.1992.11.227"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.RVW.20.00220"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1353\/pbm.1966.0027"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/ng1092-93"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/BF03403525"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199810001-00016"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-5898(05)70115-2"},{"key":"B24","first-page":"10","volume":"116","author":"Orkin SH","year":"1996","journal-title":"Bull Med Ethics"},{"issue":"102","key":"B25","first-page":"49","volume":"19","author":"Powell SK","year":"2015","journal-title":"Discov Med"},{"issue":"2","key":"B26","first-page":"142","volume":"3","author":"Kwok K","year":"2001","journal-title":"Curr Opin Mol Ther"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-3002"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094534"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.1272"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/d41573-023-00103-y"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-022-04327-7"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.56.1.86"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.67.10.6096-6104.1993"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.68.8.4998-5006.1994"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302134"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302133"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.68.5.2947-2957.1994"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.11.8989-8998.1999"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2011.287"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.9.4580-4590.2002"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2010.40"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10809-6"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2015.40"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-06-2501"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1407309"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c29356"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70039-4"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2017.11.007"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/nm1549"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.11.5804"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1038\/nm1358"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2020.05.001"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2016.02.001"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2010.07769.x"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25697-y"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33956-9"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1038\/nature04791"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801775105"},{"key":"B59","volume-title":"A Novel rAAV-amiRNA Platform Enables Potent In Vivo Gene Silencing and a Ten-Fold Enhancement of On-Target Specificity over Conventional shRNA Vectors","author":"Xie J","year":"2018"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.02.017"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.952755"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3301999"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.23.10898"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.09.004"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.1807"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2023.102111"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-022-01533-6"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1089\/10430349950017455"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302924"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.601224"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23071500"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2025"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1182"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2009.155"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-018-0095-8"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.3390\/biom13091364"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2011.209"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1126\/science.1088757"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mt.6300339"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2020.04.010"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2022.07.008"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2022.09.018"},{"key":"B83","volume":"7","author":"Lee L","year":"2019","journal-title":"BA"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.089375"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090817"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.3345\/kjp.2012.55.11.438"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21186812"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2017.05.016"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1517\/21678707.2015.1086640"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S68562"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20061783"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mt.6300012"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2008.05.013"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1038\/ng1783"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aac4358"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2017.06.011"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1510540112"},{"issue":"54582","key":"B98","volume":"9","author":"Aykul S","year":"2020","journal-title":"Elife"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2010.157"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2010.279"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(93)90218-E"},{"issue":"1","key":"B102","first-page":"105","volume":"133","author":"Clynes MA","year":"2020","journal-title":"Br Med Bull"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10872"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3026"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2015.1017205"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2016.1203217"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1177\/1535370217703975"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01312"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0244291"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1177\/0300060517706283"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2018.09.029"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2003.12.009"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2218019120"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.4161\/rna.1.2.1066"}],"container-title":["Human Gene Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.liebertpub.com\/doi\/full-xml\/10.1089\/hum.2024.022","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.liebertpub.com\/doi\/pdf\/10.1089\/hum.2024.022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:50:36Z","timestamp":1777449036000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/hum.2024.022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,1]]},"references-count":114,"journal-issue":{"issue":"9-10","published-print":{"date-parts":[[2024,5,1]]}},"alternative-id":["10.1089\/hum.2024.022"],"URL":"https:\/\/doi.org\/10.1089\/hum.2024.022","relation":{},"ISSN":["1043-0342","1557-7422"],"issn-type":[{"value":"1043-0342","type":"print"},{"value":"1557-7422","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,1]]}}}