{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:51:30Z","timestamp":1777668690671,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"7-8","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.liebertpub.com\/nv\/resources-tools\/text-and-data-mining-policy\/121\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Gene Therapy"],"published-print":{"date-parts":[[2025,4,1]]},"DOI":"10.1089\/hum.2024.186","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T04:02:56Z","timestamp":1742529776000},"page":"765-773","source":"Crossref","is-referenced-by-count":3,"title":["Creating New Cis-Regulatory Elements of HBD to Reactivate Delta-Globin"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0995-3774","authenticated-orcid":false,"given":"Lini","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, People\u2019s Republic of China"},{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diandian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, People\u2019s Republic of China"},{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weicong","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, People\u2019s Republic of China"},{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luhong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, People\u2019s Republic of China"},{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Cheng","sequence":"additional","affiliation":[{"name":"Reforgene Medicine, Guangzhou, People\u2019s Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Luo","sequence":"additional","affiliation":[{"name":"Reforgene Medicine, Guangzhou, People\u2019s Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Xu","sequence":"additional","affiliation":[{"name":"Reforgene Medicine, Guangzhou, People\u2019s Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junbin","family":"Liang","sequence":"additional","affiliation":[{"name":"Reforgene Medicine, Guangzhou, People\u2019s Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianpei","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, People\u2019s Republic of China"},{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, People\u2019s Republic of China"},{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2022.12.009"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad3312"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-020-01341-9"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0401-y"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01906-z"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2031054"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-07-863951"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34493-1"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1021\/bi00432a041"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1023\/a:1007196118200"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1006\/bcmd.1999.0245"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.1.421.421_421_427"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.10.4051.bloodjournal88104051"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.01052.x"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.85258"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/ng.637"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.23.14.5031-5042.2003"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3390\/cells11193069"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1101\/gr.164830.113"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-294751"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021014877"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.00806-15"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-023-02610-9"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1089\/crispr.2018.0014"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3583"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/hvac151"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1969.tb27776.x"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17561"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.082768"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-02-767400"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0085-0"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00904-0"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1101\/gr.098921.109"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1002\/iub.2177"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8085"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1126\/science.1242088"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-169417"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2009.11.002"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.5.1347.1347"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1711-4"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35508-7"}],"container-title":["Human Gene Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.liebertpub.com\/doi\/full-xml\/10.1089\/hum.2024.186","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.liebertpub.com\/doi\/pdf\/10.1089\/hum.2024.186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:50:52Z","timestamp":1777449052000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/hum.2024.186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,1]]},"references-count":41,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2025,4,1]]}},"alternative-id":["10.1089\/hum.2024.186"],"URL":"https:\/\/doi.org\/10.1089\/hum.2024.186","relation":{},"ISSN":["1043-0342","1557-7422"],"issn-type":[{"value":"1043-0342","type":"print"},{"value":"1557-7422","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,1]]}}}