{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T05:32:32Z","timestamp":1772429552267,"version":"3.50.1"},"reference-count":65,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.liebertpub.com\/nv\/resources-tools\/text-and-data-mining-policy\/121\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Gene Therapy Clinical Development"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1089\/humc.2014.153","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T12:06:11Z","timestamp":1423742771000},"page":"5-14","source":"Crossref","is-referenced-by-count":30,"title":["Translational Data from Adeno-Associated Virus-Mediated Gene Therapy of Hemophilia B in Dogs"],"prefix":"10.1177","volume":"26","author":[{"given":"Timothy C.","family":"Nichols","sequence":"first","affiliation":[{"name":"Francis Owen Blood Research Laboratory, Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret H.","family":"Whitford","sequence":"additional","affiliation":[{"name":"Francis Owen Blood Research Laboratory, Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valder R.","family":"Arruda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Pennsylvania Medical Center, Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA 19104."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hansell H.","family":"Stedman","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Pennsylvania Health System, Philadelphia PA 19104."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Kay","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Genetics, Stanford University, Stanford, CA 94305."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine A.","family":"High","sequence":"additional","affiliation":[{"name":"Spark Therapeutics, Philadelphia, PA 19104."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/73464"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3296"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2006.05.004"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/nm1358"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1108046"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1407309"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12411"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01460.x"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201535"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/ilar.50.2.144"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02255.x"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.24.10095"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1614021"},{"key":"B14","first-page":"635","volume":"90","author":"Belvini D","year":"2005","journal-title":"Haematologica"},{"key":"B15","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1182\/blood.V88.9.3451.bloodjournal8893451","volume":"88","author":"Mauser AE","year":"1996","journal-title":"Blood"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1006\/mthe.2001.0442"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1002\/1098-1004(200007)16:1<31::AID-HUMU6>3.0.CO;2-I"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1097\/PAT.0b013e328353443d"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.1.130"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/4743"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1089\/104303402760128513"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1446"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2388(199804\/05)14:3<224::AID-SSU6>3.0.CO;2-A"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(03)01141-0"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2388(199804\/05)14:3<238::AID-SSU8>3.0.CO;2-9"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/7439"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-07-2908"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-12-261156"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2010.73"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.534008"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-06-440123"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904377"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-09-382317"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200316887"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-09-3217"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-080093"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-02-073304"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302142"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/13518"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.8.2670"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-10-3867"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1006\/mthe.2000.0031"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/nm1549"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem360"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.11.027"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.13.6709-6714.2004"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2011.00220"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2010.51"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2006.093"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mt.6300161"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-01-306647"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2011.203"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2012.272"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3003"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402454"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-10-181479"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1172\/JCI35798"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1126\/science.1142658"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3301541"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-302729"},{"key":"B63","author":"Monahan PE","year":"2015","journal-title":"Hum Gene Ther"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2010.240"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.192219599"},{"key":"B66","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1055\/s-0037-1613063","volume":"87","author":"Hough C","year":"2002","journal-title":"Thromb Haemost"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2005.11.009"}],"container-title":["Human Gene Therapy Clinical Development"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.liebertpub.com\/doi\/full-xml\/10.1089\/humc.2014.153","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.liebertpub.com\/doi\/pdf\/10.1089\/humc.2014.153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T03:59:08Z","timestamp":1772423948000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/humc.2014.153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":65,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1089\/humc.2014.153"],"URL":"https:\/\/doi.org\/10.1089\/humc.2014.153","relation":{},"ISSN":["2324-8637","2324-8645"],"issn-type":[{"value":"2324-8637","type":"print"},{"value":"2324-8645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3]]}}}