{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:24:27Z","timestamp":1792805067477,"version":"4.5.0"},"reference-count":149,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.liebertpub.com\/nv\/resources-tools\/text-and-data-mining-policy\/121\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Gene Therapy Clinical Development"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1089\/humc.2014.154","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T12:06:08Z","timestamp":1423742768000},"page":"38-49","source":"Crossref","is-referenced-by-count":73,"title":["Ferret and Pig Models of Cystic Fibrosis: Prospects and Promise for Gene Therapy"],"prefix":"10.1177","volume":"26","author":[{"given":"Ziying","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Anatomy and Cell Biology, University of Iowa School of Medicine, Iowa City, IA 52242."},{"name":"Center for Gene Therapy of Cystic Fibrosis, University of Iowa School of Medicine, Iowa City, IA 52242."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe A.","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Iowa School of Medicine, Iowa City, IA 52242."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick L.","family":"Sinn","sequence":"additional","affiliation":[{"name":"Center for Gene Therapy of Cystic Fibrosis, University of Iowa School of Medicine, Iowa City, IA 52242."},{"name":"Department of Pediatrics, University of Iowa School of Medicine, Iowa City, IA 52242."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Olsen","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis\/Pulmonary Research and Treatment Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology, Hospital for Sick Children and University of Toronto, Toronto, ON M5G 0A4, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Paul B.","family":"McCray","sequence":"additional","affiliation":[{"name":"Center for Gene Therapy of Cystic Fibrosis, University of Iowa School of Medicine, Iowa City, IA 52242."},{"name":"Department of Pediatrics, University of Iowa School of Medicine, Iowa City, IA 52242."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Engelhardt","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, University of Iowa School of Medicine, Iowa City, IA 52242."},{"name":"Center for Gene Therapy of Cystic Fibrosis, University of Iowa School of Medicine, Iowa City, IA 52242."},{"name":"Department of Internal Medicine, University of Iowa School of Medicine, Iowa City, IA 52242."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2475911"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2772657"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1126\/science.2570460"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/347358a0"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2008.10.004"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-4710-0.00041-9"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2014.02.023"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.75.103004.142532"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05879.x"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2745"},{"key":"B11","first-page":"5121","volume-title":"The Metabolic and Molecular Basis of Inherited Disease","author":"Welsh MJ","year":"2001"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043184"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90353-R"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.65.092101.142426"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2008.09.010"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)80063-K"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199509283331302"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/ng0994-42"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118573"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1089\/hum.1994.5.5-615"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1089\/hum.1994.5.4-501"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1089\/10430349950016384"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1089\/hum.1997.8.1-15"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1089\/104303401753153956"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1089\/104303402760128577"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1089\/104303403322124792"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2007.022"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/nm0195-39"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3300390"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2004.15.1255"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2013-203309"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-1993(11)60017-9"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-0346-0165-8_4"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.2174\/138161212799315993"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200158"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2009.230"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3303014"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mt.6300277"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2005-0189OC"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1089\/hum.1998.9.18-2761"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8317"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.2147\/VAAT.S8887"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-008-8080-3"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2008.09.011"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200215217"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2003.02124.x"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2006-0313CB"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mt.6300210"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3300994"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1089\/hum.1994.5.10-1217"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1089\/hum.1995.6.7-839"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1089\/hum.1996.7.17-2101"},{"key":"B53","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1016\/S0021-9258(18)53762-5","volume":"268","author":"Flotte TR","year":"1993","journal-title":"J Biol Chem"},{"key":"B54","first-page":"658","volume":"3","author":"Conrad CK","year":"1996","journal-title":"Gene Ther"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.6.2863-2874.2004"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302527"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1021\/mp200121z"},{"key":"B58","volume-title":"Adenoviral Vectors","author":"Wivel NA","year":"1999"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.15.10219"},{"key":"B60","doi-asserted-by":"crossref","first-page":"6014","DOI":"10.1128\/JVI.72.7.6014-6023.1998","volume":"72","author":"Pickles RJ","year":"1998","journal-title":"J Virol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/ng0794-362"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302548"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1089\/hum.1998.9.5-635"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1172\/JCI34599"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1172\/JCI34773"},{"key":"B66","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/MCP.0b013e32834b14c9","volume":"17","author":"Keiser NW","year":"2011","journal-title":"Curr Opin Pulm Med"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-120-8_19"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2006-0184TR"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20433"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0412188"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2010-0224OC"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1038\/ng1192-240"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2005-0059OC"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1513\/pats.2306015"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1007\/BF00234174"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.2.479"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1007\/BF01204355"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-009-0704-9"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.24.2.3918"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.90203.2008"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1172\/JCI44235"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/S0070-2153(04)64003-8"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2006-0286OC"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1007\/BF00493372"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1038\/385810a0"},{"key":"B86","first-page":"1","volume":"111","author":"Oppenheimer EH","year":"1962","journal-title":"Bull Johns Hopkins Hosp"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.3109\/15513819609168659"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1126\/science.1163600"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090849"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1172\/JCI43052"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2014.01.035"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1172\/JCI68867"},{"key":"B93","first-page":"149","volume":"96","author":"Oppenheimer EH","year":"1973","journal-title":"Arch Pathol"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-198400031-00011"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.04.024"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1159\/000332582"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1172\/JCI60610"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1042\/CS20140059"},{"key":"B99","first-page":"241","volume":"2","author":"Oppenheimer EH","year":"1975","journal-title":"Perspect Pediatr Pathol"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-005-0049-2"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510300527"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2012-0433OC"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3000928"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2014-0250OC"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2013-0261OC"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2008.14"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1006\/mthe.2000.0198"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-0016(03)00059-5"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2010.125"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302968"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-0016(02)00021-7"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.797"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M604099200"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2012.46"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2008.261"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0813365106"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2008.100"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2008.117"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.17.10158"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409845102"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2013.92"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.13.7361-7366.2003"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5259.263"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.501"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.21.11382"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8390"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.4.2607-2614.2003"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302715"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1038\/mtna.2012.47"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3301138"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.20.12818-12827.2005"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2010.13"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00227-08"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201206-1056OC"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1038\/mtna.2013.55"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2013.137"},{"key":"B137","first-page":"503","volume-title":"American Society for Cell and Gene Therapy Conference Simultaneous Oral Abstract Sessions: Cardiovascular and Pulmonary Therapies Abstract","author":"Steines BR","year":"2014"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.2695"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2005.10.017"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1089\/hum.1997.8.6-739"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1089\/104303404322959551"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.55.04.06.db05-0927"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2013.62"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2842"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3486"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2647"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2013.11.002"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1089\/biores.2012.0218"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001868"}],"container-title":["Human Gene Therapy Clinical Development"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.liebertpub.com\/doi\/full-xml\/10.1089\/humc.2014.154","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.liebertpub.com\/doi\/pdf\/10.1089\/humc.2014.154","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T03:59:08Z","timestamp":1772423948000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/humc.2014.154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":149,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1089\/humc.2014.154"],"URL":"https:\/\/doi.org\/10.1089\/humc.2014.154","relation":{},"ISSN":["2324-8637","2324-8645"],"issn-type":[{"value":"2324-8637","type":"print"},{"value":"2324-8645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3]]}}}