{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:58:55Z","timestamp":1790474335237,"version":"4.1.0"},"reference-count":74,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.liebertpub.com\/nv\/resources-tools\/text-and-data-mining-policy\/121\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Gene Therapy Clinical Development"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1089\/humc.2017.090","type":"journal-article","created":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T00:46:58Z","timestamp":1513039618000},"page":"10-23","source":"Crossref","is-referenced-by-count":16,"title":["<i>In Vitro<\/i>\n                    Human Placental Studies to Support Adenovirus-Mediated\n                    <i>\n                      VEGF-D\n                      <sup>\u0394N\u0394C<\/sup>\n                    <\/i>\n                    Maternal Gene Therapy for the Treatment of Severe Early-Onset Fetal Growth Restriction"],"prefix":"10.1177","volume":"29","author":[{"given":"Michelle","family":"Desforges","sequence":"first","affiliation":[{"name":"Maternal and Fetal Health Research Centre, Division of Developmental Biology and Medicine, University of Manchester, Manchester, United Kingdom."},{"name":"St. Mary's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Rogue","sequence":"additional","affiliation":[{"name":"CiToxLAB France, Evreux, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Pearson","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences, pRED, F Hoffmann-La Roche, Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Rossi","sequence":"additional","affiliation":[{"name":"Magnus Growth, London, United Kingdom."},{"name":"Institute for Women's Health, University College London (UCL), London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Olearo","sequence":"additional","affiliation":[{"name":"Institute for Women's Health, University College London (UCL), London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Forster","sequence":"additional","affiliation":[{"name":"CiToxLAB France, Evreux, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Lees","sequence":"additional","affiliation":[{"name":"Magnus Growth, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil J.","family":"Sebire","sequence":"additional","affiliation":[{"name":"Institute of Child Health, University College London (UCL), London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Greenwood","sequence":"additional","affiliation":[{"name":"Maternal and Fetal Health Research Centre, Division of Developmental Biology and Medicine, University of Manchester, Manchester, United Kingdom."},{"name":"St. Mary's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin P.","family":"Sibley","sequence":"additional","affiliation":[{"name":"Maternal and Fetal Health Research Centre, Division of Developmental Biology and Medicine, University of Manchester, Manchester, United Kingdom."},{"name":"St. Mary's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna L.","family":"David","sequence":"additional","affiliation":[{"name":"Institute for Women's Health, University College London (UCL), London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Brownbill","sequence":"additional","affiliation":[{"name":"Maternal and Fetal Health Research Centre, Division of Developmental Biology and Medicine, University of Manchester, Manchester, United Kingdom."},{"name":"St. Mary's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62233-7"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.02.007"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2008.01670.x"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2009.02245.x"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1046\/j.0960-7692.2001.00591.x"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5386"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)62049-3"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-017-1226-7"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2010.02879.x"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.01.036"},{"key":"B11","unstructured":"Royal College of Obstetricians and Gynaecologists. The Investigation and Management of the Small-for-Gestational-Age Fetus. Green-top Guideline No. 31. London: Royal College of Obstetricians and Gynaecologists, 2013."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000253215.79121.75"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1827"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.117187"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.01892"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2003.t01-1-02163.x"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/380435a0"},{"key":"B18","first-page":"H586","volume":"265","author":"Ku DD","year":"1993","journal-title":"Am J Physiol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.13.1261"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0180"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1089\/hum.1997.8.15-1737"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000018588.56950.7A"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.6.1512"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2007.08.008"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M401538200"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2008.102"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2011.158"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1053\/plac.1999.0440"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.104.037234"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.05.008"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2013.214"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1177\/1933719116630411"},{"key":"B33","doi-asserted-by":"crossref","first-page":"A14","DOI":"10.1089\/hum.2014.015","volume":"26","author":"Swanson A","year":"2015","journal-title":"Human Gene Therapy"},{"key":"B34","unstructured":"Royal College of Obstetricians and Gynaecologists. The Role of Emergency and Interventional Radiology in Postpartum Haemorrhage. Good Practicc No. 6. London: Royal College of Obstetricians and Gynaecologists, 2007."},{"key":"B35","first-page":"1323","volume":"26","author":"David AL","year":"2015","journal-title":"Hum Gene Ther Clin Dev"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1089\/humc.2015.2518"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2011.062"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.082765md"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2012.10.011"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.micron.2005.12.011"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2008.07.003"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.08.037"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19980730)17:14<1537::AID-SIM872>3.0.CO;2-F"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100021"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2006.11.002"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2006.01.008"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2007.02.005"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1177\/0023677216637506"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2001.280.4.R1116"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2004.10.002"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2009.11.016"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.278.3.R677"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1053\/plac.1999.0512"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(90)90367-4"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4004(89)90012-X"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4004(85)80029-1"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.78.5.1778"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281053"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod64.3.1001"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2001.tb03798.x"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod54.3.682"},{"key":"B62","first-page":"1521","volume":"152","author":"Parry S","year":"1998","journal-title":"Am J Pathol"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1996.tb14164.x"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0029(19970701\/15)38:1\/2<52::AID-JEMT7>3.0.CO;2-W"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2003.10.019"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2005.08.002"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1990.sp018343"},{"key":"B68","first-page":"173A","volume":"16","author":"Hutchinson ES","year":"2009","journal-title":"Reprod Sci"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.121724"},{"key":"B71","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1128\/JCM.34.5.1171-1175.1996","volume":"34","author":"Kirchhoff LV","year":"1996","journal-title":"J Clin Microbiol"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.07.079"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2013.03.011"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-26512-4_14"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15880"}],"container-title":["Human Gene Therapy Clinical Development"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.liebertpub.com\/doi\/full-xml\/10.1089\/humc.2017.090","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.liebertpub.com\/doi\/pdf\/10.1089\/humc.2017.090","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T03:59:23Z","timestamp":1772423963000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/humc.2017.090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":74,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1089\/humc.2017.090"],"URL":"https:\/\/doi.org\/10.1089\/humc.2017.090","relation":{},"ISSN":["2324-8637","2324-8645"],"issn-type":[{"value":"2324-8637","type":"print"},{"value":"2324-8645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3]]}}}