{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:34:39Z","timestamp":1790044479228,"version":"4.0.1"},"reference-count":51,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,2,6]],"date-time":"2014-02-06T00:00:00Z","timestamp":1391644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2014,2,6]],"date-time":"2014-02-06T00:00:00Z","timestamp":1391644800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Aerosol Medicine and Pulmonary Drug Delivery"],"published-print":{"date-parts":[[2014,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The purpose was to design and characterize inhalable microparticulate\/nanoparticulate dry powders of mannitol with essential particle properties for targeted dry powder delivery for cystic fibrosis mucolytic treatment by dilute organic solution spray drying, and, in addition, to tailor and correlate aerosol dispersion performance delivered as dry powder inhalers based on spray-drying conditions and solid-state physicochemical properties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Organic solution advanced spray drying from dilute solution followed by comprehensive solid-state physicochemical characterization and\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      dry powder aerosolization were used.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The particle size distribution of the spray-dried (SD) powders was narrow, unimodal, and in the range of \u223c500\u2009nm to 2.0\u2009\u03bcm. The particles possessed spherical particle morphology, relatively smooth surface morphology, low water content and vapor sorption (crystallization occurred at exposure above 65% relative humidity), and retention of crystallinity by polymorphic interconversion. The emitted dose, fine particle fraction (FPF), and respirable fraction (RF) were all relatively high. The mass median aerodynamic diameters were below 4\u2009\u03bcm for all SD mannitol aerosols.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      aerosol deposition stage patterns could be tailored based on spray-drying pump rate. Positive linear correlation was observed between both FPF and RF values with spray-drying pump rates. The interplay between various spray-drying conditions, particle physicochemical properties, and aerosol dispersion performance was observed and examined, which enabled tailoring and modeling of high aerosol deposition patterns.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jamp.2013.1078","type":"journal-article","created":{"date-parts":[[2014,2,6]],"date-time":"2014-02-06T14:39:27Z","timestamp":1391697567000},"page":"81-93","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":56,"title":["Design, Characterization, and Aerosol Dispersion Performance Modeling of Advanced Spray-Dried Microparticulate\/Nanoparticulate Mannitol Powders for Targeted Pulmonary Delivery as Dry Powder Inhalers"],"prefix":"10.1177","volume":"27","author":[{"given":"Xiaojian","family":"Li","sequence":"first","affiliation":[{"name":"University of Kentucky College of Pharmacy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick G.","family":"Vogt","sequence":"additional","affiliation":[{"name":"Analytical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Don","family":"Hayes","sequence":"additional","affiliation":[{"name":"The Ohio State University College of Medicine"},{"name":"The Ohio State University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi M.","family":"Mansour","sequence":"additional","affiliation":[{"name":"The University of Arizona\u2013Tucson"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,2,6]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200304-505SO"},{"issue":"4","key":"e_1_3_3_3_2","first-page":"CD002204","article-title":"Antifungal therapies for allergic bronchopulmonary aspergillosis in people with cystic fibrosis","author":"Elphick H","year":"2000","unstructured":"Elphick H, , and Southern K: Antifungal therapies for allergic bronchopulmonary aspergillosis in people with cystic fibrosis. 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