{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:40:06Z","timestamp":1788478806773,"version":"build-2803163510"},"reference-count":40,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T00:00:00Z","timestamp":1423785600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Aerosol Medicine and Pulmonary Drug Delivery"],"published-print":{"date-parts":[[2015,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>To our knowledge, quantification of intranasal deposition of aerosol generated by Accuspray\u2122 (AS) in children has never been published. We hypothesized that deposition would vary significantly with age and with placement of the device within, or outside, of the nostril.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We tested these hypotheses in anatomically-correct physical models based on CT scans of 2-, 5-, and 12-year-old children with normal, intranasal airways. Models included a removable anterior nose (AN) with exterior facial features and interior nasal vestibule and nasal valve area and a main nasal airway (MNA), subdivided into upper (superior turbinates and olfactory area), middle (middle turbinates), and lower (inferior turbinates and nasopharynx) thirds. Aerosol was generated from distilled water admixed with\n                      <jats:sup>99m<\/jats:sup>\n                      technetium pertechnetate and administered during static airflow by AS inserted inside the right nostril (eight runs\/model), or outside the right nostril (six runs\/model). Mean aerosol Dv(50)\u00b1standard deviation was 67.8\u00b124.7\u03bcm. Deposition was quantified by 2D gamma scintigraphy and expressed as percentage of the emitted dose.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      When placed inside the nostril, mean (\u00b1standard deviation) deposition within the MNA was significantly less in the 2-year-old, compared to the 5- and 12-year-old, averaging 46.8\u00b133.8% (AN:55.4\u00b129.9%), 75.4\u00b126.7% (AN:23.3\u00b113.6%), and 72.1\u00b118.5% (AN:25.8\u00b118.5%), respectively (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt;0.05). When placed outside the nostril, MNA was significantly less in the 2- and 5-year-old compared to the 12-year-old, with 1.4\u00b12.5% (AN:69.7\u00b140.7%), 7.4\u00b19.0% (AN:77.8\u00b132.8%), and 21.1\u00b129.1% (AN:29.2\u00b119.3%), respectively (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt;0.05). Deposition in the MNA of all age models was highest when AS was placed inside the nostril (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt;0.05). Deposition in the lower third was significantly increased for the 5- and 12-year-old and in the middle third of the 5-year-old when AS was placed inside the nostril.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These results indicate that age and device placement play important roles in terms of intranasal deposition, when administering aerosol with Accuspray\u2122 to children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jamp.2014.1174","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T17:48:51Z","timestamp":1423849731000},"page":"320-333","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Intranasal Deposition of Accuspray\u2122 Aerosol in Anatomically Correct Models of 2-, 5-, and 12-Year-Old Children"],"prefix":"10.1177","volume":"28","author":[{"given":"Beth L.","family":"Laube","sequence":"first","affiliation":[{"name":"The Johns Hopkins Medical Institutions"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail","family":"Sharpless","sequence":"additional","affiliation":[{"name":"The Johns Hopkins Medical Institutions"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ami R.","family":"Vikani","sequence":"additional","affiliation":[{"name":"The George Washington University School of Medicine and Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Harrand","sequence":"additional","affiliation":[{"name":"CFD Research Corporation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simeon J.","family":"Zinreich","sequence":"additional","affiliation":[{"name":"The Johns Hopkins Medical Institutions"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Sedberry","sequence":"additional","affiliation":[{"name":"CFD Research Corporation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darin","family":"Knaus","sequence":"additional","affiliation":[{"name":"LLC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Barry","sequence":"additional","affiliation":[{"name":"LLC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Papania","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention","place":["Georgia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,2,13]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1985.tb05069.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100101380"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600770510"},{"key":"e_1_3_3_5_2","first-page":"7","article-title":"Nasal distribution of budesonide inhaled via a powder inhaler","volume":"31","author":"Thorsson L","year":"1993","unstructured":"Thorsson L, , Newman SP, , Weisz A, , Trofast E, , and Moren F: Nasal distribution of budesonide inhaled via a powder inhaler. 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