{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T12:08:39Z","timestamp":1779192519767,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2016,1,7]],"date-time":"2016-01-07T00:00:00Z","timestamp":1452124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Aerosol Medicine and Pulmonary Drug Delivery"],"published-print":{"date-parts":[[2016,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>\n                      Nebulized drugs are used in the treatment of cystic fibrosis (CF) lung disease, asthma, and COPD, and increasingly also in other chronic lung diseases. Their use in CF is reasonably evidence based, but this is not so for use in other orphan diseases. Potential side effects often have not been studied. Therefore, we evaluated the influence of nebulized drugs on ciliary activity in an\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We constructed an\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      nebulization model to examine the effect of drugs on ciliary activity. The model was validated by testing solutions with known neutral, positive, or negative effect on ciliary beat frequency (CBF). Next, the influence on CBF of other inhaled drugs was tested.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Nebulization of NaCl 0.9% had no influence on CBF, and was used as paired neutral control in further experiments. Salbutamol (Ventolin\n                      <jats:sup>\u00ae<\/jats:sup>\n                      ) had a ciliostimulatory effect (CBF +18%, CBF at t0\u2013t10\u2013t60 7.1\u20138.5\u20138.6\u2009Hz,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.002), while hypertonic saline (CBF - 11%, CBF at t0\u2013t10\u2013t60 6.5\u20135.1\u20135.9\u2009Hz,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.018) and dry air (CBF \u221210%, CBF at t0\u2013t10\u2013t60 6.8\u20135.8\u20136.1\u2009Hz,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.008) had a cilioinhibitory effect. Nebulization of tobramycin inhaled solution (TOBI\n                      <jats:sup>\u00ae<\/jats:sup>\n                      ) (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.662), colistimethate (Colistineb\n                      <jats:sup>\u00ae<\/jats:sup>\n                      ) (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.369), rhDNAse (Pulmozyme\n                      <jats:sup>\u00ae<\/jats:sup>\n                      ) (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.069), ceftazidim (Glazidim\n                      <jats:sup>\u00ae<\/jats:sup>\n                      ) (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.875), and aztreonam (Cayston\n                      <jats:sup>\u00ae<\/jats:sup>\n                      ) (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.435) did not affect CBF. Obracin\n                      <jats:sup>\u00ae<\/jats:sup>\n                      , a tobramycin containing solution manufactured for intravenous use, had a negative effect on CBF (CBF \u2013 21%, CBF at t0\u2013t10\u2013t60 6.9\u20135.2\u20134.5\u2009Hz,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.004).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Inhaled drugs that are used off-label might have an influence on ciliary activity. This must be taken into account when prescribing these drugs for non-CF indications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jamp.2015.1229","type":"journal-article","created":{"date-parts":[[2016,1,7]],"date-time":"2016-01-07T17:14:02Z","timestamp":1452186842000},"page":"378-385","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["The Influence of Nebulized Drugs on Nasal Ciliary Activity"],"prefix":"10.1177","volume":"29","author":[{"given":"Mieke","family":"Boon","sequence":"first","affiliation":[{"name":"University Hospital Gasthuisberg","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Jorissen","sequence":"additional","affiliation":[{"name":"University Hospital Gasthuisberg","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martine","family":"Jaspers","sequence":"additional","affiliation":[{"name":"University Hospital Gasthuisberg","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Augustijns","sequence":"additional","affiliation":[{"name":"KU Leuven","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois L.","family":"Vermeulen","sequence":"additional","affiliation":[{"name":"University Hospital Gasthuisberg","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marijke","family":"Proesmans","sequence":"additional","affiliation":[{"name":"University Hospital Gasthuisberg","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kris","family":"De Boeck","sequence":"additional","affiliation":[{"name":"University Hospital 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