{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:30:56Z","timestamp":1777908656243,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T00:00:00Z","timestamp":1553817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Aerosol Medicine and Pulmonary Drug Delivery"],"published-print":{"date-parts":[[2019,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Pulmonary surfactant spreads rapidly over the airway epithelium, a property that could be harnessed to transport drugs into the lungs. For efficient drug delivery, an interaction between pulmonary surfactant and the drug to be administered is likely needed. On the other hand, the interaction should not compromise the activity of surfactant or the drug once delivered\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      . The antibiotics gentamicin (an aminoglycoside) and polymyxin E represent drugs that could benefit from being delivered directly to the lung, thereby increasing local concentrations and reducing systemic side effects. Our aim was to study how the animal-derived surfactant poractant alfa (Curosurf\n                      <jats:sup>\u00ae<\/jats:sup>\n                      ) affects the activities of polymyxin E and gentamicin against\n                      <jats:italic toggle=\"yes\">Pseudomonas aeruginosa<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">In vitro<\/jats:italic>\n                      antimicrobial assays and a neonatal near-term rabbit model were used to evaluate the combinations of antibiotics and surfactant against\n                      <jats:italic toggle=\"yes\">Pseudomonas aeruginosa<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The bactericidal activity of polymyxin E, but not of gentamicin, against\n                      <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                      was partly reduced\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      in the presence of poractant alfa. In contrast, in the rabbit model of\n                      <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                      pneumonia, polymyxin E administrated together with surfactant was superior in lowering the bacterial load in the lungs compared to polymyxin E alone, without affecting plethysmographically recorded lung compliance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      The results suggest that polymyxin E interacts with poractant alfa, which reduces the antibacterial effect\n                      <jats:italic toggle=\"yes\">in vitro.<\/jats:italic>\n                      However, when polymyxin E mixed with surfactant is used in the\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      pneumonia model, increased bactericidal effect was observed. This may be due to a more efficient spreading mediated by interactions between polymyxin E and surfactant. These results warrant further studies of surfactant preparations for drug delivery against lung infections.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jamp.2018.1468","type":"journal-article","created":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T11:53:49Z","timestamp":1539950029000},"page":"110-118","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Natural Derived Surfactant Preparation As a Carrier of Polymyxin E for Treatment of\n                    <i>Pseudomonas aeruginosa<\/i>\n                    Pneumonia in a Near-Term Rabbit Model"],"prefix":"10.1177","volume":"32","author":[{"given":"Oihana","family":"Basabe-Burgos","sequence":"first","affiliation":[{"name":"Karolinska Institutet","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakub","family":"Zebialowicz","sequence":"additional","affiliation":[{"name":"Karolinska Institutet","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Stichtenoth","sequence":"additional","affiliation":[{"name":"University of L\u00fcbeck","place":["Germany"]},{"name":"Karolinska University Hospital","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tore","family":"Curstedt","sequence":"additional","affiliation":[{"name":"Karolinska University Hospital","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Bergman","sequence":"additional","affiliation":[{"name":"Karolinska University Hospital","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Johansson","sequence":"additional","affiliation":[{"name":"Karolinska Institutet","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Rising","sequence":"additional","affiliation":[{"name":"Karolinska Institutet","place":["Sweden"]},{"name":"Swedish University of Agricultural Sciences","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,3,29]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)90489-4"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000381117"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.12300"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1987.tb10552.x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.2.329"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15442.x"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(01)00106-5"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/144.4.909"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1001349107"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/430352"},{"key":"e_1_3_3_12_2","first-page":"930318","article-title":"Exogenous pulmonary surfactant as a vehicle for antimicrobials: Assessment of surfactant-antibacterial interactions in vitro","volume":"2014","author":"Birkun A","year":"2014","unstructured":"Birkun A: Exogenous pulmonary surfactant as a vehicle for antimicrobials: Assessment of surfactant-antibacterial interactions in vitro. Scientifica (Cairo). 2014; 2014:930318.","journal-title":"Scientifica (Cairo)"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00778-13"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1089\/jamp.2014.1161"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702405"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb16016.x"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000475877"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00040-09"},{"key":"e_1_3_3_19_2","first-page":"390","article-title":"Ventilator-associated pneumonia caused by Pseudomonas aeruginosa in preterm newborn infants","volume":"3","author":"Kushnareva MV","year":"2017","unstructured":"Kushnareva MV, , Markhulia KM, , Dementyeva GM, , Keshishian ES, , Shaginyan IA, , and Chernukha MY: Ventilator-associated pneumonia caused by Pseudomonas aeruginosa in preterm newborn infants. EC Paediatr. 2017; 3:390\u2013398.","journal-title":"EC Paediatr"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.060889"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(06)70580-1"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201311-395FR"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)93308-9"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00308"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1586\/erp.10.49"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-009-9148-6"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc3995"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)31462-6"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/cb3005116"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2017.09.011"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.27.020176.001443"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00254-13"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181d026f6"}],"container-title":["Journal of Aerosol Medicine and Pulmonary Drug Delivery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jamp.2018.1468","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jamp.2018.1468","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jamp.2018.1468","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:10:25Z","timestamp":1777644625000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jamp.2018.1468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,29]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,4,1]]}},"alternative-id":["10.1089\/jamp.2018.1468"],"URL":"https:\/\/doi.org\/10.1089\/jamp.2018.1468","relation":{},"ISSN":["1941-2711","1941-2703"],"issn-type":[{"value":"1941-2711","type":"print"},{"value":"1941-2703","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,29]]}}}