{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T02:17:37Z","timestamp":1785896257879,"version":"3.56.0"},"reference-count":58,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Aerosol Medicine and Pulmonary Drug Delivery"],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:p>Modeling particle deposition in the human lung requires information about the morphology of the lung in terms of simple geometric units, e.g., characterizing bronchial airways by straight cylindrical tubes. Five different regional deposition models are discussed in this section with respect to morphometric lung models and related mathematical modeling techniques: 1) one-dimensional cross-section or \u201ctrumpet\u201d model, 2) deterministic symmetric generation or \u201csingle-path\u201d model, 3) deterministic asymmetric generation or \u201cmultiple-path\u201d model, 4) stochastic asymmetric generation or \u201cmultiple-path\u201d model, and 5) single-path computational fluid and particle dynamics (CFPD) model. Current deposition models can predict the following regional deposition quantities relevant for the administration of medical aerosols: 1) regional bronchial and alveolar deposition, 2) generational lung deposition, 3) lobar deposition, 4) generational lobar deposition, and 5) generational surface deposition. Although deposition fractions predicted by the different models depend on the selection of a specific morphometric lung model and a specific set of analytical deposition equations, all models predict the same trends as functions of particle diameter and breathing parameters. In general, the overall agreement between the modeling predictions obtained by the various deposition models and the available experimental evidence indicates that current deposition models correctly predict regional and generational deposition.<\/jats:p>","DOI":"10.1089\/jamp.2020.29031.wh","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T14:57:46Z","timestamp":1596725866000},"page":"239-248","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Regional Deposition: Deposition Models"],"prefix":"10.1177","volume":"33","author":[{"given":"Werner","family":"Hofmann","sequence":"first","affiliation":[{"name":"Department of Chemistry and Physics of Materials, University of Salzburg, Salzburg, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"Human Respiratory Tract Model for Radiological Protection [Internet]. ICRP Publication 66. Oxford. 1994. www.icrp.org\/publication.asp?id=ICRP%20Publication%2066"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-87553-3"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8240(80)80060-7"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/30\/6\/004"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/02786820119122"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1975.38.6.990"},{"key":"e_1_3_3_8_2","unstructured":"Raabe OG Yeh HC Schum GM and Phalen RF: Tracheobronchial Geometry: Human Dog Rat Hamster\u2014a Compilation of Selected Data from the Project Respiratory Tract Deposition Models [Internet]. Albuquerque: U.S. Energy Research and Development Administration Division of Biomedical and Environmental Research; 1976. www.math.u-psud.fr\/~maury\/paps\/POUM_Raabe.Geom.pdf"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092200410"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092120408"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-8502(90)90121-D"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-8502(01)00167-7"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(85)90134-3"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02462290"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1975.38.1.77"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-8502(90)90122-E"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/08958370701513014"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1975.38.4.719"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/08958370802115081"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2008.02.010"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaerosci.2006.01.002"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-8502(93)90022-2"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.856311"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/02786829808965509"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.3109\/08958378.2013.876468"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaerosci.2011.05.007"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-8502(87)90069-3"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.77.6.2889"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-8502(98)00071-8"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaerosci.2004.08.008"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01752351"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1089\/jam.1989.2.49"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600821202"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1006\/faat.1995.1144"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1080\/02786820500237158"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1080\/08958370600753851"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-8502(93)90044-A"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-8502(98)00040-8"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1080\/027868201753306723"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1089\/jam.2006.19.329"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022112001003810"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1115\/1.1359525"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaerosci.2008.08.003"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaerosci.2011.07.005"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-010-0223-z"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1089\/089426804322994488"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.1.9812094"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.1115"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-8502(86)90035-2"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1080\/15298668091424933"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.84.6.1834"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsta.2000.0678"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10020460"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-8502(00)00021-5"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1089\/jam.1995.8.297"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(00)00342-2"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaerosci.2004.12.008"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.83.6.2029"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1089\/jamp.2013.1079"}],"container-title":["Journal of Aerosol Medicine and Pulmonary Drug Delivery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jamp.2020.29031.wh","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jamp.2020.29031.wh","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jamp.2020.29031.wh","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:11:00Z","timestamp":1777644660000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jamp.2020.29031.wh"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,30]]},"references-count":58,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,10,1]]}},"alternative-id":["10.1089\/jamp.2020.29031.wh"],"URL":"https:\/\/doi.org\/10.1089\/jamp.2020.29031.wh","relation":{},"ISSN":["1941-2711","1941-2703"],"issn-type":[{"value":"1941-2711","type":"print"},{"value":"1941-2703","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,30]]}}}