{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:58:43Z","timestamp":1790099923324,"version":"4.0.1"},"reference-count":47,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Aerosol Medicine and Pulmonary Drug Delivery"],"published-print":{"date-parts":[[2023,2,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Acinetobacter baumannii<\/jats:italic>\n                      -mediated bacterial pneumonia is a common disease that is harmful to human health. Dipalmitoylphosphatidylcholine (DPPC) is the major lipid component of the pulmonary surfactant (PS) found in the alveolar space; the PS helps to keep surface tension low, which allows for improved oxygen delivery. Resveratrol (RE) is a phytoalexin found in plants that is released in response to injury or infection. The therapeutic effect of Re is limited due to its low solubility and bioavailability. In this study, we report pulmonary delivery of Re-loaded DPPC liposomal large porous microparticles (RDLPMs) for treatment of\n                      <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                      -induced pneumonia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Novel RDLPMs were prepared by rotary evaporation and a freeze-drying method in this study. RDLPMs were evaluated by the particle size, electric potential,\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      release, and particle size distribution. A rat model of\n                      <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                      -mediated pneumonia was established and used for pharmacodynamic evaluations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The Re-loaded DPPC liposomes (RDLs) consisted of Re\/DPPC (1:3, mol\/mol) and DPPC\/cholesterol (3:1, w\/w), with a hydration time of 15 minutes. The RDLs had a high encapsulation efficiency of 69.8%\u2009\u00b1\u20091.6%, a mean size of 191.5\u2009\u00b1\u20094.5\u2009nm, and a high zeta potential of 12.4\u2009\u00b1\u20091.5\u2009mV. The RDLPMs were composed of mannitol\/large porous microparticles\/RDLs (1:4:2, w\/w\/w) and had a loading efficiency of 2.20%\u2009\u00b1\u20090.24%. The RDLPMs had an aerodynamic diameter (2.73\u2009\u00b1\u20090.65\u2009\u03bcm), a good fluidity (28.30\u00b0\u2009\u00b1\u20096.13\u00b0), and demonstrated high lung deposition (fine particle fraction\u2009=\u200943.33%). Surprisingly, while penicillin showed better microbial inhibition than the RDLPMs and Re groups\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      , the RDLPMs were more effective\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      The RDLPMs showed good powder properties for pulmonary delivery. The RDLPMs may inhibit the nuclear factor kappa-B pathway and downregulate the expression of cytokines downstream of tumor necrosis factor-\u03b1 and interleukin-1\u03b2. As well as, RDLPMs demonstrated some antibacterial properties against\n                      <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                      bacteria. Re, when delivered in RDLPMs as a dry powder inhaler, is a promising substitute for antibiotics in the treatment of\n                      <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                      pneumonia.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jamp.2021.0049","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T09:28:26Z","timestamp":1674638906000},"page":"2-11","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Resveratrol-Loaded Dipalmitoylphosphatidylcholine Liposomal Large Porous Microparticle Inhalations for the Treatment of Bacterial Pneumonia Caused by\n                    <i>Acinetobacter baumannii<\/i>"],"prefix":"10.1177","volume":"36","author":[{"given":"Zicheng","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Laboratory, Institute of Clinical Pharmacy and Pharmacology, Yangpu Hospital, Tongji University School of Medicine, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Laboratory, Institute of Clinical Pharmacy and Pharmacology, Yangpu Hospital, Tongji University School of Medicine, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Shanghai United Family Pudong Hospital, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Laboratory, Institute of Clinical Pharmacy and Pharmacology, Yangpu Hospital, Tongji University School of Medicine, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxia","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Laboratory, Institute of Clinical Pharmacy and Pharmacology, Yangpu Hospital, Tongji University School of Medicine, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5501-5459","authenticated-orcid":false,"given":"Lifei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Laboratory, Institute of Clinical Pharmacy and Pharmacology, Yangpu Hospital, Tongji University School of Medicine, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,2,9]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00259-0"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2016.02.012"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2013.06.009"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-015-2566-8"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv440"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/2049-632X.12125"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-9118-1_28"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-017-1916-6"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2019.03.014"},{"key":"e_1_3_5_11_2","first-page":"100","article-title":"Current situation and progress of resveratrol research","volume":"15","author":"Li J","year":"2013","unstructured":"Li J, , Xiong X, , Zeng J, et al. 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