{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:42:41Z","timestamp":1790923361638,"version":"4.1.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Aerosol Medicine and Pulmonary Drug Delivery"],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>To evaluate the safety and efficacy of 2.5 and 1.25\u2009mg nebulized salbutamol on Transient Tachypnea of the Newborn (TTN) compared with placebo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a triple-blind, phase II\/III parallel randomized controlled trial in two university-affiliated hospitals with neonatal intensive care units. Newborns with a confirmed diagnosis of TTN, with gestational age &gt;35 weeks and gestational weight &gt;2\u2009kg were included. Cases of asphyxia, meconium aspiration syndrome, and persistent pulmonary hypertension were excluded. Ninety eligible patients were randomly allocated in three intervention groups (2.5\u2009mg salbutamol, 1.25\u2009mg salbutamol, and placebo), and a single-dose nebulized product was prescribed 6 hours after the birth. Safety outcomes included postintervention tachycardia, hyperglycemia, hypokalemia, and changes in blood pressure. To evaluate the efficacy, the duration of postintervention tachypnea, TTN clinical score, and clinical and paraclinical respiratory indices were assessed. Parents, Outcome assessors, and data analyzer were blind to the intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There was no adverse reaction, including tachycardia, hypokalemia, and jitteriness. Both groups of salbutamol recipients showed significant improvement regarding respiratory rate, TTN clinical score, and oxygenation indices compared with the placebo (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      -values &lt;0.001). Nonstatistically significant higher hospital stay was observed in the placebo group. Single 2.5\u2009mg salbutamol nebulization showed a little better outcome than the dose of 1.25\u2009mg, although we could not find statistical superiority.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The newly applied single high dose of 2.5\u2009mg nebulized salbutamol is safe in treating TTN and leads to notable faster improvement of respiratory status without any considerable adverse reaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registry code:<\/jats:title>\n                    <jats:p>IRCT20190328043133N1.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jamp.2023.0043","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T10:45:42Z","timestamp":1714473942000},"page":"180-188","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Safety and Efficacy of 2.5\u2009mg and 1.25\u2009mg Nebulized Salbutamol Compared with Placebo on Transient Tachypnea of the Newborns: A Triple-Blind Phase II\/III Parallel Randomized Controlled Trial"],"prefix":"10.1177","volume":"37","author":[{"given":"Farhad Abolhasan","family":"Choobdar","sequence":"first","affiliation":[{"name":"Ali-Asghar Children's Hospital, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Vahedi","sequence":"additional","affiliation":[{"name":"Ali-Asghar Children's Hospital, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran."},{"name":"Firooz Abadi Hospital, and School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Mazouri","sequence":"additional","affiliation":[{"name":"Shahid Akbar Abadi Clinical Research Development Unit (ShACRDU), School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Torkaman","sequence":"additional","affiliation":[{"name":"Department of Pediatric, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nastaran","family":"Khosravi","sequence":"additional","affiliation":[{"name":"Ali-Asghar Children's Hospital, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasrin","family":"Khalesi","sequence":"additional","affiliation":[{"name":"Ali-Asghar Children's Hospital, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Soltani","sequence":"additional","affiliation":[{"name":"Ali-Asghar Children's Hospital, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Mohazzab","sequence":"additional","affiliation":[{"name":"School of Public Health, Iran University of Medical Sciences (IUMS), Tehran, Iran."},{"name":"Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5249-0404","authenticated-orcid":false,"given":"Rezvan","family":"Ashkanipour","sequence":"additional","affiliation":[{"name":"Ali-Asghar Children's Hospital, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran."},{"name":"Department of Pediatric, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,5,2]]},"reference":[{"key":"e_1_3_6_2_2","first-page":"CD013563","article-title":"Interventions for the management of transient tachypnoea of the newborn\u2014An overview of systematic reviews","volume":"2","author":"Bruschettini M","year":"2022","unstructured":"Bruschettini M, , Hassan KO, , Romantsik O, et al. Interventions for the management of transient tachypnoea of the newborn\u2014An overview of systematic reviews. Cochrane Database Syst Rev, 2022; 2:CD013563; doi: 10.1002\/14651858.CD013563.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_6_3_2","volume-title":"Transient Tachypnea of the Newborn","author":"Jha K","year":"2023","unstructured":"Jha K, , Nassar GN, , Makker K. Transient Tachypnea of the Newborn. 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Salbutamol for transient tachypnea of the newborn. Cochrane Database Syst Rev, 2021; 2:Cd011878; doi: 10.1002\/14651858.CD011878.pub3","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.04490653"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(89)80755-3"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.5152\/TurkArchPediatr.2021.21125"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/2333794X16645258"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2018.01.015"},{"key":"e_1_3_6_21_2","first-page":"31","article-title":"A survey of albuterol administration practices in intubated patients in the neonatal intensive care unit","volume":"47","author":"Ballard J","year":"2002","unstructured":"Ballard J, , Lugo RA, , Salyer JW. 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