{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T23:59:32Z","timestamp":1784591972450,"version":"3.55.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Aerosol Medicine and Pulmonary Drug Delivery"],"published-print":{"date-parts":[[2025,8,1]]},"abstract":"<jats:sec>\n                    <jats:title>Backgroud:<\/jats:title>\n                    <jats:p>A key attribute in selecting an oral inhaler device for chronic obstructive pulmonary disease (COPD) and asthma is its ability to dispense a high degree of pulmonary deposition of the drug at low inspiratory flows.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      In this study, the lung deposition of extrafine formulations of beclomethasone dipropionate (BDP) and formoterol fumarate (FF) (pressurized metered-dose inhaler [pMDI] and dry powder inhaler [DPI], NEXThaler) was compared with that of nonextrafine formulations of fluticasone\/salmeterol (FP\/SAL) Diskus DPI and budesonide\/formoterol (BUD\/FF) Turbuhaler DPI in 10 patients. Diskus intrathoracic (peripheral and central) lung deposition was estimated at low inhalation flow rates (30 and 40 L\/min)\n                      <jats:italic toggle=\"yes\">via<\/jats:italic>\n                      validated functional respiratory imaging (FRI) and computational fluid dynamics (CFD) methods.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The BDP\/FF NEXThaler and BDP\/FF pMDI had the highest median percentages of intrathoracic deposition, with consistent mean values of approximately 50% and 40%, respectively. The median percentage of peripheral deposition from extrafine inhalers was above 30% with BDP\/FF NEXThaler and pMDI, 5% or less with the FP\/SAL Diskus at both flow rates, and ranged between 12% and 22% with the BUD\/FF Turbuhaler DPI at flow rates of 30 and 40 L\/min, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Extrafine BDP\/FF using NEXThaler and pMDI resulted in greater peripheral deposition of both the inhaled corticosteroid and long-acting beta-agonists moieties than the nonextrafine FP\/SAL Discus and BUD\/FF DPIs did.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jamp.2024.0052","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T01:41:22Z","timestamp":1747100482000},"page":"202-210","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Lung Deposition of Extrafine Versus Nonextrafine Aerosols at Low Inhalation Flow Rates in Adult Asthma Patients: A Composition Study"],"prefix":"10.1177","volume":"38","author":[{"given":"Maciej","family":"Kupczyk","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Asthma and Allergy, Medical University, \u0141\u00f3d\u017a, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"Panek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Asthma and Allergy, Medical University, \u0141\u00f3d\u017a, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hosein","family":"Sadafi","sequence":"additional","affiliation":[{"name":"FLUIDDA NV, Kontich, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfried","family":"De Backer","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Faculty of Medicine, University of Antwerp, Antwerp, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Wojakiewicz","sequence":"additional","affiliation":[{"name":"Medical Department, Chiesi Poland Sp. z o.o., Warszawa, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"D\u0119bowski","sequence":"additional","affiliation":[{"name":"Medical Department, Chiesi Poland Sp. z o.o., Warszawa, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.12.1567"},{"issue":"4","key":"e_1_3_8_3_2","first-page":"CD012226","article-title":"Interventions to improve adherence to inhaled steroids for asthma","volume":"4","author":"Normansell R","year":"2017","unstructured":"Normansell R, , Kew KM, , Stovold E. 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