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Nanotechnology can be used in the effective treatment of several pulmonary diseases by developing therapies that are delivered in a targeted manner to select lung regions based on the disease state. Acute or chronic pulmonary disorders can benefit from this type of therapy, including respiratory distress syndrome (RDS), chronic obstructive pulmonary disease (COPD), asthma, pulmonary infections (e.g. tuberculosis,\n                    <jats:italic toggle=\"yes\">Yersinia pestis<\/jats:italic>\n                    infection, fungal infections, bacterial infections, and viral infections), lung cancer, cystic fibrosis (CF), pulmonary fibrosis, and pulmonary arterial hypertension. Modification of size and surface property renders nanoparticles to be targeted to specific sites, which can serve a vital role in innovative pulmonary drug delivery. The nanocarrier type chosen depends on the intended purpose of the formulation and intended physiological target. Liquid nanocarriers and solid-state nanocarriers can carry hydrophilic and hydrophobic drugs (e.g. small molecular weight drug molecules, large molecular weight drugs, peptide drugs, and macromolecular biological drugs), while surface modification with polymer can provide cellular targeting, controlled drug release, and\/or evasion of phagocytosis by immune cells, depending on the polymer type. Polymeric nanocarriers have versatile architectures, such as linear, branched, and dendritic forms. In addition to the colloidal dispersion liquid state, the various types of nanoparticles can be formulated into the solid state, offering important unique advantages in formulation versatility and enhanced stability of the final product. This chapter describes the different types of nanocarriers, types of inhalation aerosol device platforms, liquid aerosols, respirable powders, and particle engineering design technologies for inhalation aerosols.\n                  <\/jats:p>","DOI":"10.1089\/jamp.2024.29117.mk","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T11:25:15Z","timestamp":1724325915000},"page":"202-218","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Inhaled Nanoparticulate Systems: Composition, Manufacture and Aerosol Delivery"],"prefix":"10.1177","volume":"37","author":[{"given":"Heidi M.","family":"Mansour","sequence":"first","affiliation":[{"name":"College of Pharmacy, Skaggs Pharmaceutical Sciences Center, The University of Arizona, Tucson, Arizona, USA."},{"name":"The BIO5 Research Institute, The University of Arizona, Tucson, Arizona, USA."},{"name":"Institute of the Environment, The University of Arizona, Tucson, Arizona, USA."},{"name":"National Cancer Institute Comprehensive Cancer Center, The University of Arizona, Tucson, Arizona, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Muralidharan","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Skaggs Pharmaceutical Sciences Center, The University of Arizona, Tucson, Arizona, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Don","family":"Hayes","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Internal Medicine, Lung and Heart-Lung Transplant Programs, The Ohio State University College of Medicine, Columbus, Ohio, USA."},{"name":"The Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"43","volume-title":"Nanomedicine in Drug Delivery [Internet]","author":"Mansour HM","year":"2013","unstructured":"Mansour HM, , Park C-WJr., , H D. 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