{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:25:31Z","timestamp":1790839531589,"version":"4.1.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Adolescent and Young Adult Oncology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>This study was undertaken to determine cancer survival and describe the spectrum of cancers diagnosed among French adolescent and young adult (AYA) population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>All cases of cancer diagnosed in 15\u201324 years, recorded by all French population-based registries (18% of the French population), over the 2000\u20132016 period, were included. Age-standardized incidence rates, conventional annual percentage change (cAPC) of incidence over time, and 5-year overall survival (5yOS) were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We analyzed 2734 cancer diagnoses in adolescents and 4199 in young adults. Overall incidence rates were 231.9\/10\n                      <jats:sup>6<\/jats:sup>\n                      in 15\u201319 year olds and 354.0\/10\n                      <jats:sup>6<\/jats:sup>\n                      in 20\u201324 year olds. The most frequently diagnosed cancers in male AYA were malignant gonadal germ-cell tumors (GCT), Hodgkin lymphoma (HL), and malignant melanoma and were HL, thyroid carcinoma, and malignant melanoma in females. Cancer incidence was stable over time with a cAPC of 0.8% (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.72). For all cancers combined, 5yOS was 86.6% (95% CI: 85.8\u201387.4), &gt;85% for HL, non-Hodgkin lymphomas (NHL), GCT, thyroid carcinomas, and malignant melanomas, and around 60% and lower for osteosarcomas, Ewing tumors, hepatic carcinomas, and rhabdomyosarcomas. The 5yOS has significantly improved from 2000\u20132007 to 2008\u20132015 for all cancers pooled, with a substantial gain of 4% for 15\u201319 year olds and 3% for 20\u201324 year olds.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Notwithstanding the encouraging results for some cancers, and overall, persistent poorer survivals in AYA were shown compared to children for acute lymphoblastic leukemia, osteosarcoma, Ewing tumor, rhabdomyosarcoma, and malignant hepatic tumors. These disparities require further investigation to identify and address the causes of these inferior outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jayao.2020.0017","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T16:52:59Z","timestamp":1589561579000},"page":"29-45","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":45,"title":["Cancer Among Adolescents and Young Adults Between 2000 and 2016 in France: Incidence and Improved Survival"],"prefix":"10.1177","volume":"10","author":[{"given":"Thomas","family":"Raze","sequence":"first","affiliation":[{"name":"Registre National des Cancers de l'Enfant, Registre National des Tumeurs Solides de l'Enfant, CHRU Nancy, Vand\u0153uvre-l\u00e8s-Nancy, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Lacour","sequence":"additional","affiliation":[{"name":"Registre National des Cancers de l'Enfant, Registre National des Tumeurs Solides de l'Enfant, CHRU Nancy, Vand\u0153uvre-l\u00e8s-Nancy, France."},{"name":"Centre de Recherche en Epid\u00e9miologie et en Statistique Sorbonne-Paris Cit\u00e9 (CRESS), UMR 1153, INSERM, Universit\u00e9 Paris-Descartes, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Cowppli-Bony","sequence":"additional","affiliation":[{"name":"Registre des Tumeurs de Loire-Atlantique et Vend\u00e9e, CHU de Nantes, SIRIC-ILIAD, Nantes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Delafosse","sequence":"additional","affiliation":[{"name":"Registre G\u00e9n\u00e9ral des Cancers de l'Is\u00e8re, Meylan, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Velten","sequence":"additional","affiliation":[{"name":"Registre des Cancers du Bas-Rhin, Laboratoire d'\u00e9pid\u00e9miologie et de Sant\u00e9 Publique, Inserm UMR-S1113\/Centre Paul Strauss, Service de Sant\u00e9 Publique, Universit\u00e9 de Strasbourg, Strasbourg, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Tr\u00e9tarre","sequence":"additional","affiliation":[{"name":"Registre des Tumeurs de l'H\u00e9rault, Montpellier, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gautier","family":"Defossez","sequence":"additional","affiliation":[{"name":"Registre des Cancers de Poitou-Charentes, CHU Poitiers, Poitiers, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karima","family":"Hammas","sequence":"additional","affiliation":[{"name":"Registre des Cancers du Haut-Rhin, ARER68, Groupe Hospitalier de la R\u00e9gion de Mulhouse et Sud-Alsace (GHRMSA), Mulhouse, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Sophie","family":"Woronoff","sequence":"additional","affiliation":[{"name":"Registre des Tumeurs du Doubs, EA3181, CHRU Besan\u00e7on, Besan\u00e7on, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Ganry","sequence":"additional","affiliation":[{"name":"Registre G\u00e9n\u00e9ral du Cancer de la Somme, CHU Amiens, Amiens, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Plouvier","sequence":"additional","affiliation":[{"name":"Registre G\u00e9n\u00e9ral des Cancers de Lille et de sa R\u00e9gion, GCS-C2RC, Lille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaelle","family":"Coureau","sequence":"additional","affiliation":[{"name":"Epicene, Centre Inserm U1219\/CHU de Bordeaux, Service d'information M\u00e9dicale, Universit\u00e9 Bordeaux, Bordeaux, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Val\u00e9rie","family":"Guizard","sequence":"additional","affiliation":[{"name":"Registre G\u00e9n\u00e9ral des Tumeurs du Calvados, Caen, 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H\u00f4pitaux de Paris\/EA-3518, Institut de Recherche Saint-Louis, Universit\u00e9 de Paris, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Clavel","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Epid\u00e9miologie et en Statistique Sorbonne-Paris Cit\u00e9 (CRESS), UMR 1153, INSERM, Universit\u00e9 Paris-Descartes, Paris, France."},{"name":"Registre National des H\u00e9mopathies Malignes de l'Enfant, Villejuif, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Desandes","sequence":"additional","affiliation":[{"name":"Registre National des Cancers de l'Enfant, Registre National des Tumeurs Solides de l'Enfant, CHRU Nancy, Vand\u0153uvre-l\u00e8s-Nancy, France."},{"name":"Centre de Recherche en Epid\u00e9miologie et en Statistique Sorbonne-Paris Cit\u00e9 (CRESS), UMR 1153, INSERM, Universit\u00e9 Paris-Descartes, Paris, 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