{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T05:50:15Z","timestamp":1777787415738,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Adolescent and Young Adult Oncology"],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Childhood cancer survivors (CCS) demonstrate features of premature aging in a multitude of organ systems. The aim of this pilot study is to determine the presence of premature ocular aging features in CCS, specifically childhood acute lymphoblastic leukemia (ALL) survivors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This prospective case\u2013control study was conducted over a period of 21 months, starting July 2015 till March 2017. A total of 59 childhood ALL survivors who attended the Paediatric Oncology Clinic of University Malaya Medical Centre (UMMC) and 48 age, race, and gender-matched controls went through a series of ocular examinations and tests. Inclusion criteria used to recruit survivors were age above 16 years, history of ALL in childhood, completion of treatment for ALL, and a remission period of at least 5 years. Patients with ocular disease and those who received hematopoietic stem cell transplantation were excluded. The parameters measured were visual acuity, amplitude of accommodation, pupil cycle time (PCT), and tear break-up time (TBUT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Survivors of childhood ALL demonstrated significant differences in amplitude of accommodation, PCT, and TBUT compared to age-matched controls. Survivors had a lower median (interquartile range [IQR]) amplitude of accommodation compared to controls (11.0 D [9.0\u201313.0] vs. 12.0 D [10.5\u201315];\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.045). Survivors also showed a longer median (IQR) PCT in comparison to controls (931.00 mseconds (857.00\u20131063.00) vs. 875.50 mseconds (825.75\u2013966.00);\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.024). In addition, median (IQR) TBUT was worse in survivors in comparison to the control group (9 seconds [6\u201313] vs. 11 seconds [10\u201315];\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Survivors of childhood ALL demonstrate premature ocular aging features compared to age-matched controls. Thus, survivors may benefit from having ocular examinations as part of their routine late-effects screening to detect age-related ocular morbidities early in its course.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jayao.2020.0064","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T11:39:26Z","timestamp":1601465966000},"page":"425-431","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Premature Ocular Aging Features in Childhood Acute Lymphoblastic Leukemia Survivors"],"prefix":"10.1177","volume":"10","author":[{"given":"Sudhashini","family":"Chandrasekaran","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, UM Eye Research Centre, University Malaya, Kuala Lumpur, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norlina","family":"Ramli","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, UM Eye Research Centre, University Malaya, Kuala Lumpur, Malaysia."},{"name":"Department of Ophthalmology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marium Jamaluddin","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, UM Eye Research Centre, University Malaya, Kuala Lumpur, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Effendi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, UM Eye Research Centre, University Malaya, Kuala Lumpur, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nurul Najieha","family":"Amir","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, UM Eye Research Centre, University Malaya, Kuala Lumpur, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhuen Chiou","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, UM Eye Research Centre, University Malaya, Kuala Lumpur, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline Ka Lin","family":"Chee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Yong Loo Lin School of Medicine, National University Hospital, Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad Shafiq","family":"Azanan","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayyidatul Syahirah","family":"Abd Ghafar","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hany","family":"Ariffin","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tengku Ain","family":"Kamalden","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, UM Eye Research Centre, University Malaya, Kuala Lumpur, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,8,11]]},"reference":[{"issue":"4","key":"e_1_3_4_2_2","first-page":"229","article-title":"Study design and cohort characteristics of the childhood cancer survivor study: a multi-institutional collaborative project","volume":"38","author":"Robison LL","year":"2002","unstructured":"Robison LL, , Mertens AC, , Boice JD, et al. 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