{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T05:51:11Z","timestamp":1777787471631,"version":"3.51.4"},"reference-count":105,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Adolescent and Young Adult Oncology"],"published-print":{"date-parts":[[2022,2,1]]},"abstract":"<jats:p>Advances in cancer treatment have significantly improved childhood cancer survival, although metabolic syndrome and cardiovascular disease are common long-term complications that may occur years after treatment. Childhood cancer survivors may not receive appropriate follow-up due to lack of communication between oncologists and primary care physicians, or, from lack of awareness of possible long-term metabolic and cardiovascular complications after cancer treatment. We, therefore, reviewed current evidence on long-term effects of cancer therapy, and appropriate monitoring for long-term treatment effects in childhood cancer survivors that could lead to early detection and prompt treatment to prevent future cardiovascular events.<\/jats:p>","DOI":"10.1089\/jayao.2021.0001","type":"journal-article","created":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T15:18:26Z","timestamp":1621005506000},"page":"17-26","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Monitoring of Metabolic Syndrome and Cardiovascular Disease in Childhood Cancer Survivors"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5575-2635","authenticated-orcid":false,"given":"Yutthapong","family":"Temtanakitpaisan","sequence":"first","affiliation":[{"name":"Division of Cardiology, Bangkok Hospital Khon Kaen, Khon Kaen, Thailand."},{"name":"Faculty of Medicine, Mahasarakham University, Mahasarakham, Thailand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1368-9508","authenticated-orcid":false,"given":"Suchaorn","family":"Saengnipanthkul","sequence":"additional","affiliation":[{"name":"Division of Nutrition, Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,2,10]]},"reference":[{"key":"e_1_3_5_2_2","unstructured":"National Cancer Institute. Definition of survivorship\u2014NCI Dictionary of Cancer Terms\u2014National Cancer Institute. 2011. Accessed January23 2021 from: https:\/\/www.cancer.gov\/publications\/dictionaries\/cancer-terms\/def\/survivorship"},{"key":"e_1_3_5_3_2","unstructured":"SEER. SEER Cancer Statistics Review 1975\u20132002\u2014Previous version\u2014SEER Cancer Statistics. SEER. Accessed December11 2020 from: https:\/\/seer.cancer.gov\/archive\/csr\/1975_2002\/index.html"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21254"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa060185"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.176123"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.13.3163"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.2267"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz766"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1370\/afm.26"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-43032-0_15"},{"issue":"10","key":"e_1_3_5_12_2","first-page":"4543","article-title":"Anthracycline antibiotic-stimulated superoxide, hydrogen peroxide, and hydroxyl radical production by NADH dehydrogenase","volume":"43","author":"Doroshow JH","year":"1983","unstructured":"Doroshow JH. Anthracycline antibiotic-stimulated superoxide, hydrogen peroxide, and hydroxyl radical production by NADH dehydrogenase. Cancer Res. 1983; 43(10):4543\u201351.","journal-title":"Cancer Res"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199809243391307"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2006.06.009"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2919"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b4606"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0000000000000034"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdf167"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.4.1544"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-007-0006-4"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.49.3205"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.576850"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGEN.117.001753"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13008"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2007.136093"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.12.121"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199103213241205"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.08.005"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.12.027"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccao.2019.08.003"},{"issue":"6","key":"e_1_3_5_31_2","first-page":"CD003917","article-title":"Cardioprotective interventions for cancer patients receiving anthracyclines","volume":"2011","author":"van Dalen EC","year":"2011","unstructured":"van Dalen EC, , Caron HN, , Dickinson HO, , Kremer LC. Cardioprotective interventions for cancer patients receiving anthracyclines. Cochrane Database Syst Rev. 2011; 2011(6):CD003917.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv357"},{"key":"e_1_3_5_33_2","unstructured":"European Medicines Agency. European Medicines Agency recommends restricting the use of dexrazoxane-containing medicines. European Medicines Agency. September 2018. Accessed December11 2020 from: https:\/\/www.ema.europa.eu\/en\/news\/european-medicines-agency-recommends-restricting-use-dexrazoxane-containing-medicines"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.4473"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2018-0210"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2018.08.039"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.02.049"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2012.06.416"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.03.095"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-016-9365-z"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000389"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21478"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27308"},{"issue":"10","key":"e_1_3_5_44_2","first-page":"709","article-title":"The effect of spironolactone on morbidity and mortality in patients with severe heart failure","volume":"341","author":"Pitt B","year":"1999","unstructured":"Pitt B, , Zannad F, , Remme WJ, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med. 1999; 341(10):709\u201317.","journal-title":"Randomized Aldactone Evaluation Study Investigators. N Engl J Med"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.196"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.45.120403.095748"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.308537"},{"key":"e_1_3_5_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.07.067"},{"key":"e_1_3_5_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.05.025"},{"key":"e_1_3_5_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11845-018-1835-9"},{"key":"e_1_3_5_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjco.2020.06.002"},{"issue":"7","key":"e_1_3_5_52_2","first-page":"CD006401","article-title":"Statins for children with familial hypercholesterolemia","volume":"7","author":"Vuorio A","year":"2017","unstructured":"Vuorio A, , Kuoppala J, , Kovanen PT, et al. Statins for children with familial hypercholesterolemia. Cochrane Database Syst Rev. 2017; 7(7):CD006401.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_5_53_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1816454"},{"key":"e_1_3_5_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-020-09859-w"},{"key":"e_1_3_5_55_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.10.9777"},{"key":"e_1_3_5_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.04.013"},{"key":"e_1_3_5_57_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.1180"},{"key":"e_1_3_5_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)00656-6"},{"key":"e_1_3_5_59_2","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/317659"},{"key":"e_1_3_5_60_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00124.2017"},{"issue":"5","key":"e_1_3_5_61_2","first-page":"676","article-title":"Radiotherapy as a cause of complete atrioventricular block in Hodgkin's disease","volume":"141","author":"Cohen SI","year":"1981","unstructured":"Cohen SI, , Bharati S, , Glass J, , Lev M. Radiotherapy as a cause of complete atrioventricular block in Hodgkin's disease. An electrophysiological-pathological correlation. Arch Intern Med. 1981; 141(5):676\u20139.","journal-title":"An electrophysiological-pathological correlation. Arch Intern Med"},{"key":"e_1_3_5_62_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.284427"},{"key":"e_1_3_5_63_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.11673"},{"key":"e_1_3_5_64_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-0555"},{"key":"e_1_3_5_65_2","doi-asserted-by":"publisher","DOI":"10.1080\/08880018.2018.1425784"},{"key":"e_1_3_5_66_2","unstructured":"Children's Oncology Group. Long-term follow-up guidelines for survivors of childhood adolescent and young adult cancers. Version 5.0. Children's Oncology Group. October 2018. Accessed November1 2020 from: www.survivorshipguidelines.org\/"},{"key":"e_1_3_5_67_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22120"},{"key":"e_1_3_5_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.08.018"},{"key":"e_1_3_5_69_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2486"},{"issue":"15","key":"e_1_3_5_70_2","first-page":"1381","article-title":"Diabetes mellitus in long-term survivors of childhood cancer","volume":"169","author":"Meacham LR","year":"2009","unstructured":"Meacham LR, , Sklar CA, , Li S, et al. Diabetes mellitus in long-term survivors of childhood cancer. Increased risk associated with radiation therapy: a report for the childhood cancer survivor study. Arch Intern Med. 2009; 169(15):1381.","journal-title":"Increased risk associated with radiation therapy: a report for the childhood cancer survivor study. Arch Intern Med"},{"key":"e_1_3_5_71_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.7251"},{"key":"e_1_3_5_72_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0128"},{"key":"e_1_3_5_73_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djz152"},{"key":"e_1_3_5_74_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.4379"},{"key":"e_1_3_5_75_2","doi-asserted-by":"publisher","DOI":"10.1159\/000495698"},{"key":"e_1_3_5_76_2","doi-asserted-by":"publisher","DOI":"10.7326\/M15-2345"},{"key":"e_1_3_5_77_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.67.5.968"},{"key":"e_1_3_5_78_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.171016"},{"key":"e_1_3_5_79_2","doi-asserted-by":"publisher","DOI":"10.1080\/17446651.2019.1561271"},{"key":"e_1_3_5_80_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.06.131"},{"key":"e_1_3_5_81_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.3527"},{"key":"e_1_3_5_82_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24829"},{"key":"e_1_3_5_83_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800555"},{"key":"e_1_3_5_84_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.17.1.95"},{"key":"e_1_3_5_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)93147-F"},{"key":"e_1_3_5_86_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198601163140302"},{"key":"e_1_3_5_87_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199806043382302"},{"key":"e_1_3_5_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2011.11.008"},{"key":"e_1_3_5_89_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.2627"},{"key":"e_1_3_5_90_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.3112"},{"key":"e_1_3_5_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(97)00125-4"},{"key":"e_1_3_5_92_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.21.2831"},{"key":"e_1_3_5_93_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182a88099"},{"key":"e_1_3_5_94_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2019.2952"},{"key":"e_1_3_5_95_2","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12589"},{"key":"e_1_3_5_96_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw211"},{"key":"e_1_3_5_97_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.33.7907"},{"key":"e_1_3_5_98_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12030704"},{"key":"e_1_3_5_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.01.002"},{"issue":"2","key":"e_1_3_5_100_2","first-page":"138","article-title":"Extracellular\/circulating microRNAs and their potential role in cardiovascular disease","volume":"1","author":"Zhu H","year":"2011","unstructured":"Zhu H, , Fan G-C. Extracellular\/circulating microRNAs and their potential role in cardiovascular disease. Am J Cardiovasc Dis. 2011; 1(2):138\u201349.","journal-title":"Am J Cardiovasc Dis"},{"key":"e_1_3_5_101_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004653"},{"key":"e_1_3_5_102_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318159a593"},{"key":"e_1_3_5_103_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.11.025"},{"key":"e_1_3_5_104_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24565"},{"key":"e_1_3_5_105_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-017-0260-0"},{"key":"e_1_3_5_106_2","doi-asserted-by":"publisher","DOI":"10.2147\/JMDH.S117945"}],"container-title":["Journal of Adolescent and Young Adult Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jayao.2021.0001","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jayao.2021.0001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jayao.2021.0001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:50:58Z","timestamp":1777492258000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jayao.2021.0001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,1]]},"references-count":105,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2,1]]}},"alternative-id":["10.1089\/jayao.2021.0001"],"URL":"https:\/\/doi.org\/10.1089\/jayao.2021.0001","relation":{},"ISSN":["2156-5333","2156-535X"],"issn-type":[{"value":"2156-5333","type":"print"},{"value":"2156-535X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,1]]}}}