{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T05:31:49Z","timestamp":1777786309607,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Adolescent and Young Adult Oncology"],"published-print":{"date-parts":[[2024,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>There is limited research on the psychological impact of cancer for teenagers and young adults (TYAs) and the role of protective factors such as resilience. This study investigated associations between resilience and psychosocial outcomes in this group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Data were collected from TYAs (aged 16\u201324) who attended the TYA cancer clinic at Guy's Hospital between 2013 and 2021. Participants (\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      \u2009=\u200963) completed psychosocial questionnaires within 4 weeks of their treatment start date (\n                      <jats:italic toggle=\"yes\">T<\/jats:italic>\n                      <jats:sub>1<\/jats:sub>\n                      ) and again between 9 and 15 months later (\n                      <jats:italic toggle=\"yes\">T<\/jats:italic>\n                      <jats:sub>2<\/jats:sub>\n                      ). We used separate multivariable linear regression models to analyze associations of resilience (Brief Resilience Questionnaire) with outcomes measured at\n                      <jats:italic toggle=\"yes\">T<\/jats:italic>\n                      <jats:sub>2,<\/jats:sub>\n                      including symptoms of depression (Patient Health Questionnaire [PHQ]-9), anxiety (Generalized Anxiety Disorder [GAD]-7), and subjective quality of life. Models were adjusted for age, gender, ethnicity, and\n                      <jats:italic toggle=\"yes\">T<\/jats:italic>\n                      <jats:sub>1<\/jats:sub>\n                      outcome assessments.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Higher resilience at\n                      <jats:italic toggle=\"yes\">T<\/jats:italic>\n                      <jats:sub>1<\/jats:sub>\n                      was associated with increased anxiety (\n                      <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                      \u2009=\u20091.68; bootstrapped confidence interval [95% CI \u22120.28 to 3.19]), depression (\n                      <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                      \u2009=\u20091.24; [\u22120.85 to 2.90]), and quality of life (5.76; [\u22120.88 to 15.60]). In contrast, an increase in resilience over time was associated with decreases in the same period in anxiety (\n                      <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22123.16; [\u22125.22 to \u22121.47]) and depression (\n                      <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22122.36, [\u22124.41 to \u22120.58]), and an increase in quality of life (\n                      <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                      \u2009=\u20099.82, [\u22120.24 to 21.13]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Increases in resilience during cancer treatment were associated with reduced symptoms of depression and anxiety in TYAs. We discuss factors likely to influence these outcomes, the implications for psychosocial interventions in this population, and identify further research to explore the impact of other factors such as diagnosis and treatment type.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jayao.2022.0159","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T14:30:24Z","timestamp":1693319424000},"page":"331-337","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["The Association of Resilience with Psychosocial Outcomes in Teenagers and Young Adults with Cancer"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1160-733X","authenticated-orcid":false,"given":"Kathryn","family":"Hughes","sequence":"first","affiliation":[{"name":"Institute of Psychiatry, Psychology &amp; Neuroscience, King's College London, London, United Kingdom."},{"name":"South London and Maudsley NHS Foundation Trust, London, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clare E.H.","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Lavelle","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, Psychology &amp; Neuroscience, King's College London, London, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewan","family":"Carr","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Health Informatics, King's College London, London, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susie M.D.","family":"Henley","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, Psychology &amp; Neuroscience, King's College London, London, United Kingdom."},{"name":"Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/ANS.0000000000000292"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/pon.5621"},{"key":"e_1_3_7_4_2","unstructured":"NHS England. NHS Cancer Services for Teenagers and Young Adults. 2015. Available from: https:\/\/www.england.nhs.uk\/commissioning\/wp-content\/uploads\/sites\/12\/2015\/12\/nhs-canc-serv-tya.pdf [Last accessed: March26 2022]."},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2017.0040"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/NCC.0000000000000450"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.4103\/2347-5625.311005"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/pon.5183"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2006.01062.x"},{"issue":"2","key":"e_1_3_7_10_2","first-page":"S61","article-title":"Feasibility, acceptability, and usefulness of the resilience enhancement for adolescents and young adults with cancer and healthcare providers (REACH) intervention","volume":"65","author":"Phillips C","year":"2018","unstructured":"Phillips C, , Haase J. Feasibility, acceptability, and usefulness of the resilience enhancement for adolescents and young adults with cancer and healthcare providers (REACH) intervention. Pediatr Blood Cancer, 2018; 65 (Supplement 2):S61.","journal-title":"Pediatr Blood Cancer"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2016.0015"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S202432"},{"issue":"3","key":"e_1_3_7_13_2","first-page":"108","article-title":"Young adults with cancer: Mental adjustment and psychological distress","volume":"26","author":"Garcia S","year":"2017","unstructured":"Garcia S, , Calderon C, , Tarruella MM, et al. Young adults with cancer: Mental adjustment and psychological distress. 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