{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T08:30:08Z","timestamp":1793262608854,"version":"4.5.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Adolescent and Young Adult Oncology"],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:p>\n                    Data on gonadotoxicity of chemotherapies are essential to better counsel young females and males about the risk of infertility and to better indicate fertility preservation measures before cancer therapies. However, such data have not recently been reviewed for bone cancer. Therefore, a systematic literature search was conducted considering papers published since 2000. This study is part of the FertiTOX\n                    <jats:sup>\u00ae<\/jats:sup>\n                    project, which aims to improve the lack of data regarding gonadotoxicity of cancer therapies to enable more accurate counseling regarding fertility preservation. Only relapse-free women and men were included. Gonadotoxic therapy-induced suspected infertility was defined as very low anti-mullerian hormone, high gonadotropin concentration, amenorrhea, oligomenorrhea, azoospermia, or oligozoospermia. The quality of the individual studies was assessed using the Newcastle\u2013Ottawa Scale (NOS). In total, 11 out of 831 studies were included in the review. Suspected infertility was found in 10\/190 (5.1%, range 0%\u201366%) of female patients with osteosarcoma (six studies), in 24\/46 (52.2%, range 46%\u2013100%) of male patients with osteosarcoma (three studies), in 18\/138 (13.0%, range 3%\u201318%) of female patients with Ewing\u2019s sarcoma (three studies), and in 34\/38 (89.5%) of male patients with Ewing\u2019s sarcoma (one study). A risk calculation in relation to specific chemotherapies was not possible. Risk of suspected infertility tends to be higher in Ewing\u2019s sarcoma in which all patients received chemotherapies with alkylating agents. Two of the 11 included studies received a high NOS quality score, whereas the remaining nine studies received a low quality score, mainly because of the lack of a comparator group. Published data are too limited for precise estimation of the gonadotoxicity. However, data indicate clinically relevant risk for infertility, supporting counseling patients before chemotherapy about fertility preservation measures.\n                  <\/jats:p>","DOI":"10.1089\/jayao.2023.0185","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T07:57:36Z","timestamp":1713340656000},"page":"597-606","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["A Systematic Review of the Gonadotoxicity of Osteosarcoma and Ewing\u2019s Sarcoma Chemotherapies in Postpubertal Females and Males"],"prefix":"10.1177","volume":"13","author":[{"given":"Susanna","family":"Weidlinger","sequence":"first","affiliation":[{"name":"Division of Gynecological Endocrinology and Reproductive Medicine, University Women\u2019s Hospital, Inselspital Bern, University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satu","family":"Graber","sequence":"additional","affiliation":[{"name":"Division of Gynecological Endocrinology and Reproductive Medicine, University Women\u2019s Hospital, Inselspital Bern, University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Bratschi","sequence":"additional","affiliation":[{"name":"Division of Gynecological Endocrinology and Reproductive Medicine, University Women\u2019s Hospital, Inselspital Bern, University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janna","family":"Pape","sequence":"additional","affiliation":[{"name":"Division of Gynecological Endocrinology and Reproductive Medicine, University Women\u2019s Hospital, Inselspital Bern, University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"Koll\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Inselspital Bern, University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Karrer","sequence":"additional","affiliation":[{"name":"Medical Library, University Library Bern, University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4303-2734","authenticated-orcid":false,"given":"Michael","family":"von Wolff","sequence":"additional","affiliation":[{"name":"Division of Gynecological Endocrinology and Reproductive Medicine, University Women\u2019s Hospital, Inselspital Bern, University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,8,2]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17222-X"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.08.011"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq146"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-0611-5549"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-021-02081-w"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.49.2678"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.09.013"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoaa052"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-018-1269-4"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/pon.4990"},{"key":"e_1_3_6_12_2","unstructured":"American Cancer Society. 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