{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T08:30:06Z","timestamp":1793262606403,"version":"4.5.0"},"reference-count":46,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Adolescent and Young Adult Oncology"],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:p>\n                    Increasing awareness of gonadotoxicity in cancer treatments and infertility risk is essential for counseling young cancer patients. While fertility preservation options are available in many countries, limited data on gonadotoxicity hinder recommendations, especially for soft tissue cancers. This review, part of the FertiTOX project (\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.fertitox.com\">www.fertitox.com<\/jats:ext-link>\n                    ), organized by FertiPROTEKT (\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.fertiprotekt.com\">www.fertiprotekt.com<\/jats:ext-link>\n                    ), aims to address this knowledge gap to improve fertility preservation guidance.\n                  <\/jats:p>\n                  <jats:p>We performed a systematic literature search on gonadotoxicity in soft tissue sarcoma (STS) cancer treatments. Only patients without metastases or recurrent disease were considered. \u201cSuspected infertility\u201d was defined based on low ovarian reserve parameters, low inhibin B levels, high gonadotropin concentration, gonadal dysfunction, amenorrhea, oligomenorrhea, azoospermia, or oligozoospermia due to limited infertility data. The study quality was assessed using the Newcastle\u2013Ottawa Scale.<\/jats:p>\n                  <jats:p>The search yielded 3309 abstracts, with 138 undergoing full-text analysis. Eight studies on STS were included. Suspected infertility was observed in 20 of 28 females (71.4%, range 0\u2013100%) and 38 of 63 males (60.3%, range 34.8\u2013100%) with STS. Six of the eight studies received high-quality scores on the NOS, while two received a fair score.<\/jats:p>\n                  <jats:p>Our data suggest a high risk of infertility from chemotherapy in pre- and postpubertal STS survivors. This underscores the importance of considering fertility preservation measures when counseling these patients.<\/jats:p>","DOI":"10.1089\/jayao.2024.0057","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T12:54:56Z","timestamp":1720788896000},"page":"803-812","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Systematic Review of the Gonadotoxicity and Risk of Infertility of Soft Tissue Sarcoma Chemotherapies in Pre- and Postpubertal Females and Males"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7601-479X","authenticated-orcid":false,"given":"Marcel","family":"Steinmann","sequence":"first","affiliation":[{"name":"Division of Gynecological Endocrinology and Reproductive Medicine, Wome\u2019s Hospital, Lucerne Cantonal Hospital, Lucerne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Rietschin","sequence":"additional","affiliation":[{"name":"Division of Gynecological Endocrinology and Reproductive Medicine, University Wome\u0144s Hospital, Inselspital Bern, University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Pagano","sequence":"additional","affiliation":[{"name":"Division of Gynecological Endocrinology and Reproductive Medicine, University Wome\u0144s Hospital, Inselspital Bern, University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Karrer","sequence":"additional","affiliation":[{"name":"Medical Library, University Library Bern, University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"Koll\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Inselspital Bern, University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Weidlinger","sequence":"additional","affiliation":[{"name":"Division of Gynecological Endocrinology and Reproductive Medicine, University Wome\u0144s Hospital, Inselspital Bern, University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4303-2734","authenticated-orcid":false,"given":"Michael","family":"von Wolff","sequence":"additional","affiliation":[{"name":"Division of Gynecological Endocrinology and Reproductive Medicine, University Wome\u0144s Hospital, Inselspital Bern, University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,12,2]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2022.0035"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23252"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0051-2"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21605"},{"key":"e_1_3_6_6_2","volume-title":"Perspektive Fertilit\u00e4t Indikation Und Durchf\u00fchrung Fertilit\u00e4tsprotektiver Ma\u00dfnahmen Bei Onkologischen Und Nicht-Onkologischen Erkrankungen","author":"Balcerek M","year":"2020","unstructured":"Balcerek M, , Barnbrock A, , Behringer K, et al. 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