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We seek to evaluate long-term toxicities and their impacts on survivors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients treated for cervical cancer with radiation therapy between ages 18 and 39 in the years 2000\u20132010 in British Columbia were eligible. One hundred eligible patients were identified and mailed a package containing a questionnaire devised by a multidisciplinary team and validated patient-reported quality of life surveys for patients with cervical cancer, the European Organization for Research and Treatment of Cancer (EORTC) QLQ-30 and CX-24.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 22 responses were received. The average time since treatment was 17.0 years (range 12\u201322). Fertility preservation prior to treatment was discussed with 41% of respondents and offered to 36%. A single respondent had a child after treatment through adoption. The mean EORTC Quality of Life score was rated as 63.9. Mean functional status scores include 84.4, 83.3, 67.1, 70.6, and 77 for physical, role, emotional, cognitive, and social functioning, respectively. Elevated symptom scores include sexual\/vaginal functioning (53.5), sexual worry (55.6), diarrhea (38.1), body image concerns (41.7), peripheral neuropathy (39.7), and menopausal symptoms (38.1). Many patients (32%) indicated sexual and vaginal health symptoms impacting quality of life. Other common symptoms include permanent bowel changes (27%), bladder changes (27%), mood disorders (27%), and lymphedema (18%). Multiple respondents (18%) commented on regrets for not pursuing fertility preservation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Long-term survivors of AYA cervix cancer have significant concerns, mood disorders, premature menopausal symptoms, and fertility issues. Respondents indicated a desire for improved fertility counseling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jayao.2024.0140","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T18:53:01Z","timestamp":1740163981000},"page":"392-400","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Long-Term Toxicities of Adolescent and Young Adults Who Underwent Radiation Therapy for Cervix Cancer: A Cross-Sectional Analysis"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1684-4157","authenticated-orcid":false,"given":"Andrew G.","family":"Pritchard","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, BC Cancer\u2014Vancouver, Vancouver, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Altas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna V.","family":"Tinker","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, BC Cancer\u2014Vancouver, Vancouver, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwa","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, BC Cancer\u2014Vancouver, Vancouver, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Goddard","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, BC Cancer\u2014Vancouver, Vancouver, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, BC Cancer\u2014Vancouver, Vancouver, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1816-2599","authenticated-orcid":false,"given":"Sarah N.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, BC Cancer\u2014Vancouver, Vancouver, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,3]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.212097"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2019.0001"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2017.04.010"},{"key":"e_1_3_5_5_2","unstructured":"National Cancer Institute. Adolescents and Young Adults (AYAs) with Cancer [Internet]. 2015. Available from: https:\/\/www.cancer.gov\/types\/aya [Last accessed: September25 2023]."},{"key":"e_1_3_5_6_2","doi-asserted-by":"crossref","unstructured":"Bleyer WA Barr RD. editors. Cancer in adolescents and young adults [Internet]. Berlin Heidelberg: Springer; 2007. (Pediatric Oncology). Available from: https:\/\/link.springer.com\/10.1007\/978-3-540-68152-6 [Last accessed: September25 2023].","DOI":"10.1007\/978-3-540-68152-6"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2023.0040"},{"key":"e_1_3_5_8_2","unstructured":"Adolescent and Young Adult Oncology Review Group. Closing the Gap: Research and Care Imperatives for Adolescents and Young Adults with Cancer. [Internet]. US Dept of Health and Human Services; 2006. 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