{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:05:15Z","timestamp":1777529115261,"version":"3.51.4"},"reference-count":53,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Integrative and Complementary Medicine"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Current treatments for osteoarthritis (OA) pain and stiffness have limitations, including adverse effects. Therefore, effective and safe complementary or alternative therapies are needed. Dietary supplement GJ 191, comprising\n                      <jats:italic toggle=\"yes\">Epimedium, Dioscorea, and Salvia miltiorrhiza<\/jats:italic>\n                      extracts, may address this need.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This randomized, double-blind, placebo-controlled study investigated GJ 191 supplementation on knee OA symptoms. Seventy-two adults (40\u201375 years) with mild to moderate knee OA and mild to moderate knee pain were enrolled. The Knee Injury and Osteoarthritis Outcome Score (KOOS), Pain Visual Analog Scale (VAS), Quality of Life questionnaire, knee joint range of motion, serum C-reactive protein, and rescue medication use were assessed. The Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) pain and stiffness scores were computed using KOOS scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Decreases in WOMAC pain scores were reported by both GJ 191 and placebo groups after 6 (\u22121.78\u2009\u00b1\u20092.71 and \u22121.34\u2009\u00b1\u20091.93, respectively;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.01) and 12 (\u22122.31\u2009\u00b1\u20092.83 and \u22121.59\u2009\u00b1\u20092.69, respectively;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.01) weeks, with no significant difference between groups. There were decreases in WOMAC stiffness scores for participants supplemented with GJ 191 by 0.53\u2009\u00b1\u20091.22 and 0.72\u2009\u00b1\u20091.46 (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u22640.02) after 6 and 12 weeks, respectively, with respective decreases of 0.81\u2009\u00b1\u20091.51 and 0.75\u2009\u00b1\u20091.85 (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u22640.03) for those on placebo. Significant improvements in current pain, as assessed by the Pain VAS, and bodily pain were reported by the GJ 191 group after 6 and 12 weeks, while the placebo group only reported significant improvements in these measures after 12 weeks. GJ 191 supplementation was safe and well tolerated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>There was no significant difference in pain and stiffness scores between GJ 191 and placebo over the 12 weeks. While both groups reported improvements in WOMAC pain from baseline, improvements in current and bodily pain were experienced sooner with GJ 191 than placebo and were sustained over the study period. GJ 191 supplementation was safe and well tolerated. (CTR#: NCT04395547).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jicm.2023.0124","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T10:00:36Z","timestamp":1728900036000},"page":"54-63","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["A Randomized, Double-Blind, Placebo-Controlled Study Investigating the Safety and Efficacy of a Herbal Formulation on Knee Joint Function in Adults with Knee Osteoarthritis"],"prefix":"10.1177","volume":"31","author":[{"given":"Li","family":"Li","sequence":"first","affiliation":[{"name":"Chenland Nutritionals, Inc., Irvine, CA, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Chenland Nutritionals, Inc., Irvine, CA, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanglong","family":"Wang","sequence":"additional","affiliation":[{"name":"Chenland Nutritionals, Inc., Irvine, CA, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiancheng","family":"Zong","sequence":"additional","affiliation":[{"name":"Chenland Nutritionals, Inc., Irvine, CA, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zengliang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine College, Inner Mongolia Medical University, Inner Mongolia, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengcan","family":"Zou","sequence":"additional","affiliation":[{"name":"Chenland Nutritionals, Inc., Irvine, CA, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Cao","sequence":"additional","affiliation":[{"name":"Clinical Research Center, The Affiliated Hospital of Qingdao University, Qingdao City, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2629-3900","authenticated-orcid":false,"given":"Zimin","family":"Liu","sequence":"additional","affiliation":[{"name":"Chenland Nutritionals, Inc., Irvine, CA, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.03.036"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.22171"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/lds038"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22412"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1703856114"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(12)61729-2"},{"key":"e_1_3_7_8_2","unstructured":"FDA. 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