{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:07:25Z","timestamp":1791068845280,"version":"4.1.0"},"reference-count":46,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Integrative and Complementary Medicine"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Intraoperative anxiety is a common problem when Monitored Anesthesia Care (MAC) is used instead of general anesthesia during minor surgical procedures such as port catheter placement. Nonpharmacological anxiolytics such as aromatherapy have been studied for their effects on preoperative anxiety, but no placebo-controlled study of aromatherapy during surgeries under MAC has yet been performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      After IRB approval, 70 patients were randomized 1:1 to receive either a lavender\/peppermint aromatherapy patch (Elequil Aromatabs\n                      <jats:sup>\u00ae<\/jats:sup>\n                      ; Beekley Corporation) or a matching placebo patch. The primary outcome, time to readiness for discharge from postoperative acute care units (PACU; min), was assessed every 15\u2009min until a modified postanesthesia recovery score for ambulatory patients (PARSAP) score of 18 or higher was reached. In the preoperative holding area, the assigned patch\/placebo was activated and affixed to a folded towel placed aside the subject's head, contralateral to the side of the planned surgery. The towel and patch\/placebo were discarded when the subject left the operating room (OR).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      No difference was found between the treatment and placebo groups on the primary outcome of time to discharge readiness (mean [standard deviation, SD]: 82 [15] vs. 89 [21] min, respectively,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.131). No difference was found between the treatment and placebo groups on the secondary outcomes of intraoperative midazolam dose, intraoperative opioid dose, intraoperative ondansetron dose, or intraoperative promethazine dose. No difference was found between the treatment and placebo groups in the proportion of subjects requiring rescue postoperative nausea and vomiting (PONV) medication in the PACU or the proportion of subjects requiring opioids in the PACU. No difference was found between the treatment and placebo groups in pain intensity in PACU, average PONV score in PACU, or patient satisfaction in PACU. PACU patient satisfaction was high for both the patch and placebo groups (35\/35 [100%] vs. 32\/34 [94%] \u201cvery satisfied,\u201d\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.239).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Aromatherapy treatment is not indicated intraoperatively to reduce anxiety or the use of antiemetics in patients requiring Port catheter placement. Trial registration: Clinicaltrials.gov, identifier: NCT05328973.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jicm.2023.0416","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T14:51:51Z","timestamp":1710859911000},"page":"840-847","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Use of a Combination Lavender\/Peppermint Aromatherapy Patch During Port Catheter Placement Under Monitored Anesthesia Care Does Not Reduce Time to Discharge Readiness: A Randomized Controlled Trial"],"prefix":"10.1177","volume":"30","author":[{"given":"Neil","family":"Bailard","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Cukierman","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas \u201cNorberto Quirno\u201d University Hospital (CEMIC), Buenos Aires, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan J.","family":"Guerra-Londono","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas \u201cNorberto Quirno\u201d University Hospital (CEMIC), Buenos Aires, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ervin","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carin","family":"Hagberg","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Sauer","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, University of Bonn, Bonn, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3156-1682","authenticated-orcid":false,"given":"Juan P.","family":"Cata","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA."},{"name":"Anesthesiology and Surgical Oncology Research Group, Houston, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,9,16]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-85139-z"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmn.2022.03.004"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-10862-0"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-008-0449-6"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2016.03.025"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.1108"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.2147\/ppa.S80330"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.4172\/2324-903x.1000153"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.13328"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/rmr.0000000000000238"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28093771"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/ncc.0000000000000551"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.explore.2023.06.002"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.2147\/jpr.S226312"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.31486\/toj.18.0014"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2010.0862"},{"key":"e_1_3_6_18_2","unstructured":"Freeman M Ayers C Peterson C et al. 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