{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:04:43Z","timestamp":1777529083352,"version":"3.51.4"},"reference-count":60,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Integrative and Complementary Medicine"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This scoping review aimed to map the adverse reactions in the oral mucosa and face caused by the use of natural products.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>\n                      This review was performed according to the Joanna Briggs Institute Manual for Evidence Synthesis and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines, with a protocol registered in the Open Science Framework (DOI\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/10.17605\/OSF.IO\/R57D8\">10.17605\/OSF.IO\/R57D8<\/jats:ext-link>\n                      ). The search was carried out systematically using PubMed, Scopus, Web of Science, Embase, LILACS, and LIVIVO databases, as well as gray literature through Google Scholar and OpenGrey. Reports of clinical cases on the adverse effects of natural products on the oral mucosa or perioral region of the face resulted from inappropriate use or self-medication were included. Data from the included studies were described in a narrative form.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Seven hundred and six studies were identified, and after removing duplicates and applying the eligibility criteria, 28 studies were included. The year of publication ranged from 1976 to 2022. The studies were conducted in 19 countries. Fifty patients were mentioned in the included studies and 34 were female (68%). The natural products most related to adverse reactions were propolis (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200917), with manifestations such as perioral eczema, edema, erosions, erythema, allergic contact dermatitis, and garlic (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20099), with manifestations such as chemical burn, burning sensation, vesicles and blisters, crusts, and ulcerations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Propolis and garlic were the natural products with the most reported adverse effects on the oral mucosa and perioral region.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jicm.2023.0675","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T15:59:25Z","timestamp":1709654365000},"page":"720-734","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Adverse Effects of Natural Products in the Oral Mucosa and Face: A Scoping Review"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5579-8844","authenticated-orcid":false,"given":"D\u00e9bora e Silva","family":"Campos","sequence":"first","affiliation":[{"name":"Department of Restorative Dentistry, Federal University of Paraiba, Jo\u00e3o Pessoa, Para\u00edba, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5550-0294","authenticated-orcid":false,"given":"Isis de Ara\u00fajo Ferreira","family":"Muniz","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Federal University of Paraiba, Jo\u00e3o Pessoa, Para\u00edba, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9495-1987","authenticated-orcid":false,"given":"Helo\u00edsa Nunes","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Federal University of Paraiba, Jo\u00e3o Pessoa, Para\u00edba, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4107-5661","authenticated-orcid":false,"given":"Rosemary Sadami Arai","family":"Shinkai","sequence":"additional","affiliation":[{"name":"Department of Community Dentistry, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8178-0982","authenticated-orcid":false,"given":"Thiago Gomes da","family":"Trindade","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9477-7037","authenticated-orcid":false,"given":"D\u00facia Caldas","family":"Cosme-Trindade","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Federal University of Paraiba, Jo\u00e3o Pessoa, Para\u00edba, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,8,21]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2017.02.006"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2017.02.007"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2017.08.008"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2017.02.001"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2021.03.012"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6794"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.14712\/18059694.2018.38"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1998.tb05892.x"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1987.tb02626.x"},{"issue":"4","key":"e_1_3_4_11_2","first-page":"303","article-title":"Delayed contact sensitivity on the lips and oral mucosa due to propolis-case report","volume":"11","author":"Brailo V","year":"2006","unstructured":"Brailo V, , Boras VV, , Alajbeg I, et al. 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