{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T13:16:20Z","timestamp":1783602980680,"version":"3.55.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Integrative and Complementary Medicine"],"published-print":{"date-parts":[[2025,12,1]]},"DOI":"10.1089\/jicm.2024.0703","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T10:34:02Z","timestamp":1776767642000},"page":"1021-1030","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of LIV-52 for the Treatment of Hepatic Disorders: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"31","author":[{"given":"Anshu","family":"Priya","sequence":"first","affiliation":[{"name":"Centre for Advanced Research, K.G.M.U, Lucknow, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munmun","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Multidisciplinary Research Unit (MRU), RIMS, Ranchi, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjani","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Multidisciplinary Research Unit (MRU), RIMS, Ranchi, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kusum","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, RIMS, Ranchi, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, RIMS, Ranchi, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoti","family":"Ranjan","sequence":"additional","affiliation":[{"name":"Department of Multidisciplinary Research Unit (MRU), RIMS, Ranchi, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6340-2468","authenticated-orcid":false,"given":"Lakhan","family":"Majhee","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, RIMS, Ranchi, India."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.24875\/AIDSRev.M22000052"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu12092627"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(22)00020-6"},{"issue":"5","key":"e_1_3_3_5_2","first-page":"329","article-title":"Physiopathology of nonalcoholic fatty liver disease: From diet to nutrigenomics","volume":"25","author":"Meneghel P","year":"2022","unstructured":"Meneghel P, , Pinto E, , Russo FP. Physiopathology of nonalcoholic fatty liver disease: From diet to nutrigenomics. Curr Opin Clin Nutr Metab Care, 2022; 25(5):329\u2013333.","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/837939"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181b766ed"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2013.10.005"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.1.110304.100230"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17091575"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i23.7312"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00509"},{"issue":"2","key":"e_1_3_3_13_2","first-page":"51","article-title":"Meta-analysis of 50 phase III clinical trials in evaluation of efficacy and safety of Liv. 52 in infective hepatitis","volume":"12","author":"Kolhapure SA","year":"2004","unstructured":"Kolhapure SA, , Mitra SK. Meta-analysis of 50 phase III clinical trials in evaluation of efficacy and safety of Liv. 52 in infective hepatitis. Med Update, 2004; 12(2):51.","journal-title":"Med Update"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.22037\/ijpr.2010.734"},{"key":"e_1_3_3_15_2","first-page":"694","article-title":"Hepatoprotective effect of LIV. 52 against CCL4 induced lipid peroxidation in the liver of rats","volume":"32","author":"Pandey S","year":"1994","unstructured":"Pandey S, , Gujrati VR, , Shanker K. Hepatoprotective effect of LIV. 52 against CCL4 induced lipid peroxidation in the liver of rats. Ind J Exp Biol, 1994; 32:694\u2013697.","journal-title":"Ind J Exp Biol"},{"issue":"8","key":"e_1_3_3_16_2","first-page":"762","article-title":"Hepatoprotective effects of Liv-52 on ethanol induced liver damage in rats","volume":"37","author":"Sandhir R","year":"1999","unstructured":"Sandhir R, , Gill KD. Hepatoprotective effects of Liv-52 on ethanol induced liver damage in rats. Indian J Exp Biol, 1999; 37(8):762\u2013766.","journal-title":"Indian J Exp Biol"},{"issue":"5","key":"e_1_3_3_17_2","first-page":"738","article-title":"Efficacy of an indigenous compound preparation (Liv-52) in acute viral hepatitis-a double blind study","volume":"64","author":"Sama SK","year":"1976","unstructured":"Sama SK, , Krishnamurthy L, , Ramachandran K, , Lal K. Efficacy of an indigenous compound preparation (Liv-52) in acute viral hepatitis-a double blind study. Indian J Med Res, 1976; 64(5):738\u2013742.","journal-title":"Indian J Med Res"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2004.10.003"},{"issue":"1","key":"e_1_3_3_19_2","first-page":"1","article-title":"medicinal values of clerodendrum phlomidis: A review","volume":"7","author":"Prakash R","year":"2005","unstructured":"Prakash R. medicinal values of clerodendrum phlomidis: A review. Intr J Pharmacol Biological Sci, 2005; 7(1):1\u20137.","journal-title":"Intr J Pharmacol Biological Sci"},{"key":"e_1_3_3_20_2","unstructured":"Sch\u00fcnemann HJBJ Bro\u017cek J Guyatt G et al. Handbook for grading the quality of evidence and the strength of recommendations using the GRADE approach. 2013."},{"issue":"5","key":"e_1_3_3_21_2","first-page":"41","article-title":"Evaluation of efficacy and safety of Liv. 52 DS tablets in acute viral hepatitis: A prospective, double-blind, randomized, placebo-controlled, phase III clinical trial","volume":"12","author":"Baijal R","year":"2004","unstructured":"Baijal R, , Patel N, , Kolhapure SA. Evaluation of efficacy and safety of Liv. 52 DS tablets in acute viral hepatitis: A prospective, double-blind, randomized, placebo-controlled, phase III clinical trial. Medicine Update, 2004; 12(5):41\u201353; doi: 10.1.1.567.3823","journal-title":"Medicine Update"},{"issue":"7","key":"e_1_3_3_22_2","first-page":"388","article-title":"A clinical comparative study to evaluate the efficacy and safety of Liv. 52 DS tablets in Non-Alcoholic Steatohepatitis (NASH)","volume":"4","author":"Maity SG","year":"2015","unstructured":"Maity SG, , Mandal AK. A clinical comparative study to evaluate the efficacy and safety of Liv. 52 DS tablets in Non-Alcoholic Steatohepatitis (NASH). World J Pharm Res, 2015; 4(7):388\u2013414.","journal-title":"World J Pharm Res"},{"issue":"1","key":"e_1_3_3_23_2","first-page":"14","article-title":"Liv. 52 in viral hepatitis with special reference to its use in precoma and coma","volume":"14","author":"Mitra DK","year":"1974","unstructured":"Mitra DK, , Ashrafuddin S, , Talib SH. Liv. 52 in viral hepatitis with special reference to its use in precoma and coma. Probe, 1974; 14(1):14\u201322.","journal-title":"Probe"},{"issue":"2","key":"e_1_3_3_24_2","first-page":"155","article-title":"Clinical management of severe acute hepatic failure with special reference to Liv. 52 in therapy","volume":"17","author":"Sethi JP","year":"1978","unstructured":"Sethi JP, , Sharma M. Clinical management of severe acute hepatic failure with special reference to Liv. 52 in therapy. Probe, 1978; 17(2):155\u2013158.","journal-title":"Probe"},{"key":"e_1_3_3_25_2","first-page":"4","article-title":"A study of serum glycolytic enzymes and serum B hepatitis in relation to Liv. 52 therapy","volume":"26","author":"Patney NL","year":"1986","unstructured":"Patney NL, , Pachori S. A study of serum glycolytic enzymes and serum B hepatitis in relation to Liv. 52 therapy. The Med & Sur, 1986; 26:4\u20139.","journal-title":"The Med & Sur"},{"issue":"2","key":"e_1_3_3_26_2","first-page":"111","article-title":"Liv. 52 therapy in viral hepatitis","volume":"11","author":"Patel GT","year":"1972","unstructured":"Patel GT, , Mruthyunjayanna BP, , Seetharam TD, et al. Liv. 52 therapy in viral hepatitis. Probe, 1972; 11(2):111\u2013119.","journal-title":"Probe"},{"key":"e_1_3_3_27_2","first-page":"127","article-title":"The Ayurvedic drug LIV. 52 in patients with alcoholic cirrhosis. Results of a prospective, randomized, double-blind, placebo-controlled clinical trial","volume":"26","author":"Fleig W","year":"1997","unstructured":"Fleig W, , Morgan MY, , H\u00f6lzer M. The Ayurvedic drug LIV. 52 in patients with alcoholic cirrhosis. Results of a prospective, randomized, double-blind, placebo-controlled clinical trial. In J Hepatol, 1997; 26:127.","journal-title":"In J Hepatol"},{"issue":"7","key":"e_1_3_3_28_2","first-page":"31","article-title":"Evaluation of Liv. 52 DS tablet as a hepatoprotective agent in prophylaxis with statin therapy","volume":"15","author":"Das JKL","year":"2007","unstructured":"Das JKL, , Prasad SR, , Mitra SK. Evaluation of Liv. 52 DS tablet as a hepatoprotective agent in prophylaxis with statin therapy. Med Update, 2007; 15(7):31\u201336.","journal-title":"Med Update"},{"key":"e_1_3_3_29_2","first-page":"153","article-title":"Comparative Efficay of Five Indigenous Compound Formulations in Patients of Acute Viral Hepatitis","author":"Dange SV","year":"1989","unstructured":"Dange SV, , Patki PS, , Pawar SS, et al. Comparative Efficay of Five Indigenous Compound Formulations in Patients of Acute Viral Hepatitis. Liver Care & Cure in Ayurveda Kindle Edition, 1989:153.","journal-title":"Liver Care & Cure in Ayurveda Kindle Edition"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-8741(02)00263-5"},{"key":"e_1_3_3_31_2","first-page":"362","article-title":"Role of various types of treatment in infectious hepatitis","volume":"3","author":"Arora JK","year":"1969","unstructured":"Arora JK. Role of various types of treatment in infectious hepatitis. Armed Forces Med. J, 1969; 3:362.","journal-title":"Armed Forces Med. J"},{"key":"e_1_3_3_32_2","first-page":"353","article-title":"Liv. 52 in infective hepatitis","volume":"5","author":"Jaffari SMH","year":"1969","unstructured":"Jaffari SMH, , Raj S. Liv. 52 in infective hepatitis. The Antiseptic, 1969; 5:353.","journal-title":"The Antiseptic"},{"issue":"8","key":"e_1_3_3_33_2","first-page":"491","article-title":"Liv. 52 in acute viral hepatitis\u2013Results of a double blind study","volume":"75","author":"Habibullah CM","year":"1978","unstructured":"Habibullah CM, , Chandra V, , Padmanaban CG, et al. Liv. 52 in acute viral hepatitis\u2013Results of a double blind study. The Antiseptic, 1978; 75(8):491.","journal-title":"The Antiseptic"},{"issue":"8","key":"e_1_3_3_34_2","first-page":"659","article-title":"Viral hepatitis in children","volume":"12","author":"Rao VS","year":"1975","unstructured":"Rao VS, , Reddi YR, , Rohini K. Viral hepatitis in children. Indian Pediatrics, 1975; 12(8):659\u2013663.","journal-title":"Indian Pediatrics"},{"issue":"1","key":"e_1_3_3_35_2","first-page":"35","article-title":"Role of Liv. 52 and steroids in the management of viral hepatitis in children","volume":"14","author":"Reddi YR","year":"1974","unstructured":"Reddi YR, , Rohini K, , Kusuma G, et al. Role of Liv. 52 and steroids in the management of viral hepatitis in children. Probe, 1974; 14(1):35\u201350.","journal-title":"Probe"},{"issue":"3","key":"e_1_3_3_36_2","first-page":"164","article-title":"Management of Steatorrhoea of cirrhosis of the liver by an indigenous drug\u2014Liv. 52","volume":"15","author":"Patney NL","year":"1976","unstructured":"Patney NL, , Jasuja RK, , Kumar A. Management of Steatorrhoea of cirrhosis of the liver by an indigenous drug\u2014Liv. 52. Probe, 1976; 15(3):164\u2013179.","journal-title":"Probe"},{"issue":"2","key":"e_1_3_3_37_2","first-page":"101","article-title":"Liv. 52-A new therapeutic agent in the management of Steatorrhoea of cirrhosis of the liver","volume":"21","author":"Patney NI","year":"1974","unstructured":"Patney NI, , Jasuja RK, , Kumar A. Liv. 52-A new therapeutic agent in the management of Steatorrhoea of cirrhosis of the liver. Probe, 1974; 21(2):101\u2013104.","journal-title":"Probe"}],"container-title":["Journal of Integrative and Complementary Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jicm.2024.0703","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jicm.2024.0703","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jicm.2024.0703","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T12:37:17Z","timestamp":1783600637000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jicm.2024.0703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,2]]},"references-count":36,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12,1]]}},"alternative-id":["10.1089\/jicm.2024.0703"],"URL":"https:\/\/doi.org\/10.1089\/jicm.2024.0703","relation":{},"ISSN":["2768-3605","2768-3613"],"issn-type":[{"value":"2768-3605","type":"print"},{"value":"2768-3613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,2]]}}}