{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:36:59Z","timestamp":1789663019676,"version":"4.0.1"},"reference-count":30,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Interferon &amp; Cytokine Research"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:p>\n                    Neonatal\n                    <jats:italic toggle=\"yes\">Chlamydia trachomatis<\/jats:italic>\n                    pneumonia has been associated with respiratory sequelae in later life. We recently established a mouse model of neonatal pulmonary\n                    <jats:italic toggle=\"yes\">Chlamydia muridaum<\/jats:italic>\n                    infection and found an important contribution of IFN-\u03b3 to protective immunity. In this study, we further characterized the role of Th1-type cytokines; IL-12, IFN-\u03b3, and IFN-\u03b3 signaling using mice genetically deficient in IL-12, IFN-\u03b3, or IFN-\u03b3 receptor 1. All 3 knockout (KO) mice challenged intranasally with\n                    <jats:italic toggle=\"yes\">C. muridarum<\/jats:italic>\n                    1 day after birth exhibited 100% mortality by day 17 post-challenge whereas wild-type (WT) animals survived the monitoring period of 1 month. The KO mice exhibited greater lung bacterial burdens and enhanced dissemination to the liver, compared to WT animals. The inflammatory cellular infiltration in\n                    <jats:italic toggle=\"yes\">C. muridarum<\/jats:italic>\n                    -challenged KO animals was significantly reduced in the lungs, but markedly enhanced in the livers of the KO mice compared to similarly challenged WT mice. It was also found that a deficiency in IL-12 or IFN-\u03b3 resulted in correspondingly reduced IFN-\u03b3 or IL-12 production, respectively, suggesting an intricate interdependence in the induction of these cytokines. Collectively, these results suggest that the IL-12\/IFN-\u03b3 axis induces pulmonary cellular infiltration, induces bacterial clearance from the lung, reduces dissemination to other organs, and promotes the survival of the host during neonatal pulmonary chlamydial infection.\n                  <\/jats:p>","DOI":"10.1089\/jir.2009.0083","type":"journal-article","created":{"date-parts":[[2010,2,28]],"date-time":"2010-02-28T18:37:45Z","timestamp":1267382265000},"page":"407-415","source":"Crossref","is-referenced-by-count":23,"title":["The Contribution of Interleukin-12\/Interferon-\u03b3 Axis in Protection Against Neonatal Pulmonary\n                    <i>Chlamydia muridarum<\/i>\n                    Challenge"],"prefix":"10.1177","volume":"30","author":[{"given":"Madhulika","family":"Jupelli","sequence":"first","affiliation":[{"name":"University of Texas at San Antonio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale M.","family":"Selby","sequence":"additional","affiliation":[{"name":"Wilford Hall Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Neal","family":"Guentzel","sequence":"additional","affiliation":[{"name":"University of Texas at San Antonio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Chambers","sequence":"additional","affiliation":[{"name":"University of Texas at San Antonio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G.","family":"Forsthuber","sequence":"additional","affiliation":[{"name":"University of Texas at San Antonio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangming","family":"Zhong","sequence":"additional","affiliation":[{"name":"University of Texas at San Antonio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashlesh K.","family":"Murthy","sequence":"additional","affiliation":[{"name":"University of Texas at San Antonio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard P.","family":"Arulanandam","sequence":"additional","affiliation":[{"name":"University of Texas at San Antonio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,6,1]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.11.4830-4833.1996"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197702102960604"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.63.2.198"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.56.8.2023-2027.1988"},{"issue":"2","key":"e_1_3_3_6_1","first-page":"L219","article-title":"Airway recruitment of leukocytes in mice is dependent on alpha4-integrins and vascular cell adhesion molecule-1","volume":"272","author":"Chin JE","year":"1997","unstructured":"Chin JE, , Hatfield CA, , Winterrowd GE, , Brashler JR, , Vonderfecht SL, , Fidler SF, , Griffin RL, , Kolbasa KP, , Krzesicki RF, , Sly LM, , Staite ND, , Richards IM. 1997. 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