{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T13:22:28Z","timestamp":1781529748427,"version":"3.54.1"},"reference-count":90,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Interferon &amp; Cytokine Research"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:p>\n                    Interferon-gamma (IFN-\u03b3) is a paracrine inhibitor of melanocytes and genetic variability due to intron 1 polymorphisms in\n                    <jats:italic toggle=\"yes\">IFNG<\/jats:italic>\n                    has been reported to be associated with increased risk for several autoimmune diseases. The aim of present study was to determine whether intron 1 +874A\/T (rs2430561) and CA microsatellite (rs3138557) polymorphisms in\n                    <jats:italic toggle=\"yes\">IFNG<\/jats:italic>\n                    are associated with generalized vitiligo (GV) susceptibility and expression of\n                    <jats:italic toggle=\"yes\">IFNG<\/jats:italic>\n                    and intercellular adhesion molecule-1 (\n                    <jats:italic toggle=\"yes\">ICAM1<\/jats:italic>\n                    ) affects the disease onset and progression. Here we report that\n                    <jats:italic toggle=\"yes\">IFNG<\/jats:italic>\n                    CA microsatellite but not +874A\/T may be a genetic risk factor for GV; however, +874T allele plays a crucial role in increased expression of\n                    <jats:italic toggle=\"yes\">IFNG<\/jats:italic>\n                    mRNA and protein levels which could affect the onset and progression of the disease. Active GV patients showed increased IFNG levels compared to stable GV patients. The genotype-phenotype analysis revealed that\n                    <jats:italic toggle=\"yes\">IFNG<\/jats:italic>\n                    expression levels were higher in patients with +874 TT genotypes and 12 CA repeats. Patients with the early age of onset showed higher\n                    <jats:italic toggle=\"yes\">IFNG<\/jats:italic>\n                    expression and female GV patients showed higher\n                    <jats:italic toggle=\"yes\">IFNG<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">ICAM1<\/jats:italic>\n                    expression implicating gender biasness and involvement of IFN-\u03b3 in early onset of the disease. Moreover, the increased IFN-\u03b3 levels in patients lead to increased\n                    <jats:italic toggle=\"yes\">ICAM1<\/jats:italic>\n                    expression, which could be a probable link between cytokines and T-cell involvement in pathogenesis of GV.\n                  <\/jats:p>","DOI":"10.1089\/jir.2012.0171","type":"journal-article","created":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T10:42:39Z","timestamp":1371552159000},"page":"646-659","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":66,"title":["Involvement of Interferon-Gamma Genetic Variants and Intercellular Adhesion Molecule-1 in Onset and Progression of Generalized Vitiligo"],"prefix":"10.1177","volume":"33","author":[{"given":"Mitesh","family":"Dwivedi","sequence":"first","affiliation":[{"name":"The Maharaja Sayajirao University of Baroda","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naresh C.","family":"Laddha","sequence":"additional","affiliation":[{"name":"The Maharaja Sayajirao University of Baroda","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kriti","family":"Shah","sequence":"additional","affiliation":[{"name":"The Maharaja Sayajirao University of Baroda","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bela J.","family":"Shah","sequence":"additional","affiliation":[{"name":"B.J. Medical College and Civil Hospital","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasheedunnisa","family":"Begum","sequence":"additional","affiliation":[{"name":"The Maharaja Sayajirao University of Baroda","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,11,1]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.36.2.187"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711690205"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00032.x"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.501"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1995.01690150078015"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0999"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09140.x"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/PCMR.12105"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2013.04.026"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2011.00892.x"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2008.00462.x"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2001.7815"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/08830189809084493"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(88)90023-2"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.164.259"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2009.02307.x"},{"issue":"6","key":"e_1_3_3_18_1","first-page":"S18","article-title":"Interferon-gamma gene microsatellite polymorphisms in patients with biopsy-proven giant cell arteritis and isolated polymyalgia rheumatic","volume":"22","author":"Gonzalez-Gay MA","year":"2004","unstructured":"Gonzalez-Gay MA, , Hajeer AH, , Dababneh A, , Garcia-Porrua C, , Amoli MM, , Llorca J, , Ollier WE. 2004. Interferon-gamma gene microsatellite polymorphisms in patients with biopsy-proven giant cell arteritis and isolated polymyalgia rheumatic. Clin Exp Rheumatol, 22,6:S18\u2013S20.","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20060"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/298859a0"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902778"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.12.031"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02657-X"},{"key":"e_1_3_3_24_1","first-page":"1412","article-title":"Mutation screening of interferon-gamma (IFN-\u03b3) as a candidate gene for asthma","volume":"27","author":"Hayden C","year":"1997","unstructured":"Hayden C, , Pereira E, , Rye P, , Palmer L, , Gibson N, , Palenque M, , Hagel I, , Lynch N, , Goldblatt J, , Lesou\u00ebf P. 1997. Mutation screening of interferon-gamma (IFN-\u03b3) as a candidate gene for asthma. Clin Exp Allergy, 27:1412\u20131416.","journal-title":"Clin Exp Allergy"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02550.x"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.21.3.925-930.1978"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200203050-00001"},{"key":"e_1_3_3_28_1","first-page":"292","article-title":"Interferon gamma gene polymorphism as a biochemical marker in Egyptian atopic patients","volume":"19","author":"Hussein YM","year":"2009","unstructured":"Hussein YM, , Ahmad AS, , Ibrahem MM, , El Tarhouny SA, , Shalaby SM, , Elshal AS, , El Said M. 2009. Interferon gamma gene polymorphism as a biochemical marker in Egyptian atopic patients. J Investig Allergol Clin Immunol, 19:292\u2013298.","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11000.x"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1089\/107999000312595"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2272"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.12"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908547"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12276556"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399401003362"},{"key":"e_1_3_3_36_1","first-page":"223","article-title":"Th1 \/Th2 balance: the hypothesis, its limitations, and implications for health and disease","volume":"8","author":"Kidd P","year":"2003","unstructured":"Kidd P. 2003. Th1 \/Th2 balance: the hypothesis, its limitations, and implications for health and disease. Altern Med Rev, 8:223\u2013246.","journal-title":"Altern Med Rev"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.117572"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02563.x"},{"issue":"3","key":"e_1_3_3_39_1","first-page":"224","article-title":"Expression and polimorphism of IFN\u03b3 gene in patients with cervical cancer","volume":"30","author":"Kordi Tamandani MK","year":"2008","unstructured":"Kordi Tamandani MK, , Sobti RC, , Shekari M, , Mukesh M, , Suri V. 2008. Expression and polimorphism of IFN\u03b3 gene in patients with cervical cancer. Exp Oncol, 30,3:224\u2013229.","journal-title":"Exp Oncol"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2005.00242.x"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052298"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12103"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2007.10.002"},{"key":"e_1_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01605.x"},{"key":"e_1_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.1159\/000131485"},{"key":"e_1_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363775"},{"key":"e_1_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04259.x"},{"key":"e_1_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1993.01680290066010"},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12413.x"},{"key":"e_1_3_3_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-5769(01)00184-9"},{"key":"e_1_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.5.518"},{"key":"e_1_3_3_52_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.2.273"},{"key":"e_1_3_3_53_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2002.1o049.x"},{"key":"e_1_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.127859"},{"key":"e_1_3_3_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-008-0904-8"},{"key":"e_1_3_3_56_1","first-page":"981","article-title":"Genetic epidemiology of vitiligo: multilocus recessivity cross-validated","volume":"55","author":"Nath SK","year":"1994","unstructured":"Nath SK, , Majumder PP, , Nordlund JJ. 1994. Genetic epidemiology of vitiligo: multilocus recessivity cross-validated. Am J Hum Genet, 55:981\u2013990.","journal-title":"Am J Hum Genet"},{"key":"e_1_3_3_57_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.157.3.1020"},{"key":"e_1_3_3_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470987100"},{"key":"e_1_3_3_59_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.158.8.3666"},{"key":"e_1_3_3_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2012.06.013"},{"key":"e_1_3_3_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)92863-7"},{"key":"e_1_3_3_62_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2370.1999.00122.x"},{"key":"e_1_3_3_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(00)00167-1"},{"key":"e_1_3_3_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.603"},{"key":"e_1_3_3_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2012.01.011"},{"key":"e_1_3_3_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2006.01834.x"},{"key":"e_1_3_3_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(97)84664-6"},{"key":"e_1_3_3_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/2.9.1508"},{"key":"e_1_3_3_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201591"},{"key":"e_1_3_3_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(07)96002-2"},{"key":"e_1_3_3_71_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0603252"},{"key":"e_1_3_3_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0736-8046.2004.21512.x"},{"key":"e_1_3_3_73_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.26928"},{"key":"e_1_3_3_74_1","first-page":"526","article-title":"Vitiligo: pathomechanisms and genetic polymorphism of susceptible genes","volume":"44","author":"Shajil EM","year":"2006","unstructured":"Shajil EM, , Chatterjee S, , Agrawal D, , Bagchi T, , Begum R. 2006b. Vitiligo: pathomechanisms and genetic polymorphism of susceptible genes. Ind J Exp Biol, 44:526\u2013539.","journal-title":"Ind J Exp Biol"},{"key":"e_1_3_3_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2007.00406.x"},{"key":"e_1_3_3_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.377"},{"key":"e_1_3_3_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.240"},{"key":"e_1_3_3_78_1","first-page":"1","article-title":"Inhibition of IFN-gamma as a method of treatment of various autoimmune diseases, including skin diseases","volume":"56","author":"Skurkovich B","year":"2006","unstructured":"Skurkovich B, , Skurkovich S. 2006. Inhibition of IFN-gamma as a method of treatment of various autoimmune diseases, including skin diseases. Ernst Schering Res Found Workshop, 56:1\u201327.","journal-title":"Ernst Schering Res Found Workshop"},{"key":"e_1_3_3_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2007.00384.x"},{"key":"e_1_3_3_80_1","doi-asserted-by":"publisher","DOI":"10.1159\/000131501"},{"key":"e_1_3_3_81_1","doi-asserted-by":"publisher","DOI":"10.1186\/gm199"},{"key":"e_1_3_3_82_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.98.11040949"},{"key":"e_1_3_3_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2005.01987.x"},{"key":"e_1_3_3_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2006.02907.x"},{"key":"e_1_3_3_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2006.00355.x"},{"key":"e_1_3_3_86_1","first-page":"403","article-title":"Interferon gamma (IFN-\u03b3) & interleukin-4 (IL-4) gene variants & cytokine levels in pulmonary tuberculosis","volume":"124","author":"Vidyarani M","year":"2006","unstructured":"Vidyarani M, , Selvaraj P, , Prabhu Anand S, , Jawahar MS, , Adhilakshmi AR, , Narayanan PR. 2006. Interferon gamma (IFN-\u03b3) & interleukin-4 (IL-4) gene variants & cytokine levels in pulmonary tuberculosis. Indian J Med Res, 124:403\u2013410.","journal-title":"Indian J Med Res"},{"key":"e_1_3_3_87_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.LAB.0000069521.42488.1B"},{"key":"e_1_3_3_88_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018907"},{"key":"e_1_3_3_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12478093"},{"key":"e_1_3_3_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)70181-6"},{"key":"e_1_3_3_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2005.06.004"}],"container-title":["Journal of Interferon &amp; Cytokine Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jir.2012.0171","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jir.2012.0171","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jir.2012.0171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:32:28Z","timestamp":1777455148000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jir.2012.0171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":90,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1089\/jir.2012.0171"],"URL":"https:\/\/doi.org\/10.1089\/jir.2012.0171","relation":{},"ISSN":["1079-9907","1557-7465"],"issn-type":[{"value":"1079-9907","type":"print"},{"value":"1557-7465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11]]}}}