{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:55:05Z","timestamp":1777701305756,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Interferon &amp; Cytokine Research"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:p>\n                    Interleukin 18 (interferon gamma-inducing factor) (IL18) is an important proinflammatory cytokine that belongs to the IL1 family. This study investigated whether IL18 single-nucleotide polymorphisms (SNPs) are associated with the susceptibility to alopecia areata (AA) in a Korean population. Two hundred thirty-three AA patients and 243 healthy control subjects were recruited. One promoter SNP (rs187238, \u2212137G\/C) and exonic SNP (rs549908, Ser35Ser) in IL18 were genotyped using direct sequencing. SNPStats, SPSS 18.0, and Haploview version 4.2 programs were used to evaluate genetic data. Multiple logistic regression models were used to determine odds ratios, 95% confidence intervals, and\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    values. Tested 2 SNPs (rs187238 and rs549908) were associated with the development of AA (rs187238,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =0.002 in a codominant model 1,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =0.0048 in a dominant model,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =0.02 in a log-additive model,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =0.023 in allele distribution; rs549908,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =0.003 in a codominant model 1,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =0.0052 in a dominant model,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =0.016 in a log-additive model,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =0.015 in allele distribution). Our data suggest that the IL18 may be a risk factor for AA susceptibility.\n                  <\/jats:p>","DOI":"10.1089\/jir.2013.0055","type":"journal-article","created":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T13:40:13Z","timestamp":1390311613000},"page":"349-353","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Association Between Interleukin 18 Polymorphisms and Alopecia Areata in Koreans"],"prefix":"10.1177","volume":"34","author":[{"given":"Su Kang","family":"Kim","sequence":"first","affiliation":[{"name":"Kyung Hee University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hae Jeong","family":"Park","sequence":"additional","affiliation":[{"name":"Kyung Hee University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo-Ho","family":"Chung","sequence":"additional","affiliation":[{"name":"Kyung Hee University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Kyung Hee University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hosik","family":"Seok","sequence":"additional","affiliation":[{"name":"Kyung Hee University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bark-Lynn","family":"Lew","sequence":"additional","affiliation":[{"name":"College of Medicine, Kyung Hee University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo-Young","family":"Sim","sequence":"additional","affiliation":[{"name":"College of Medicine, Kyung Hee University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,5,1]]},"reference":[{"issue":"1","key":"e_1_3_2_2_1","first-page":"15","article-title":"Epidemiologic and genetic characteristics of alopecia areata (part 2)","volume":"21","author":"Alzolibani AA","year":"2012","unstructured":"Alzolibani AA, , Zari S, , Ahmed AA. 2012. Epidemiologic and genetic characteristics of alopecia areata (part 2). Acta Dermatovenerol Alp Panonica Adriat, 21(1):15\u201319.","journal-title":"Acta Dermatovenerol Alp Panonica Adriat"},{"issue":"4","key":"e_1_3_2_3_1","first-page":"535","article-title":"Increased IL-18 in patients with systemic lupus erythematosus: relations with Th-1, Th-2, pro-inflammatory cytokines and disease activity. IL-18 is a marker of disease activity but does not correlate with pro-inflammatory cytokines","volume":"20","author":"Amerio P","year":"2002","unstructured":"Amerio P, , Frezzolini A, , Abeni D, , Teofoli P, , Girardelli CR, , De Pita O, , Puddu P. 2002. Increased IL-18 in patients with systemic lupus erythematosus: relations with Th-1, Th-2, pro-inflammatory cytokines and disease activity. IL-18 is a marker of disease activity but does not correlate with pro-inflammatory cytokines. Clin Exp Rheumatol, 20(4):535\u2013538.","journal-title":"Clin Exp Rheumatol"},{"issue":"4","key":"e_1_3_2_4_1","first-page":"224","article-title":"IL-18 in autoimmunity: review","volume":"17","author":"Boraschi D","year":"2006","unstructured":"Boraschi D, , Dinarello CA. 2006. IL-18 in autoimmunity: review. Eur Cytokine Netw, 17(4):224\u2013252.","journal-title":"Eur Cytokine Netw"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-13-107"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.9758\/cpn.2012.10.2.88"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13273-012-0031-7"},{"issue":"5","key":"e_1_3_2_8_1","first-page":"757","article-title":"HLA class II antigen associations help to define two types of alopecia areata","volume":"33","author":"Colombe BW","year":"1995","unstructured":"Colombe BW, , Price VH, , Khoury EL, , Garovoy MR, , Lou CD. 1995. HLA class II antigen associations help to define two types of alopecia areata. J Am Acad Dermatol, 33(5 Pt 1):757\u2013764.","journal-title":"J Am Acad Dermatol"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70518-X"},{"issue":"5","key":"e_1_3_2_10_1","first-page":"367","article-title":"Alopecia areata: genetic complexity underlies clinical heterogeneity","volume":"17","author":"Dudda-Subramanya R","year":"2007","unstructured":"Dudda-Subramanya R, , Alexis AF, , Siu K, , Sinha AA. 2007. Alopecia areata: genetic complexity underlies clinical heterogeneity. 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