{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:54:10Z","timestamp":1777701250260,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Interferon &amp; Cytokine Research"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:p>\n                    Human interleukin-29 (IL-29), a helical cytokine with interferon-like activities, is currently being developed as a clinical biotherapeutic to treat chronic hepatitis C infection and some cancers. As such, the World Health Organization (WHO) has recognized a need for biological standardization of IL-29 and the establishment of an internationally available reference reagent of IL-29. In order to accomplish this, an international collaborative study that evaluates WHO candidate reference reagents of IL-29 was instigated by the National Institute for Biological Standards and Control (NIBSC) in 2010 and was carried out in the succeeding year. Two preparations of human sequence recombinant IL-29, one expressed in murine NS0 cells and the other in\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    , were formulated and lyophilized at NIBSC before evaluation in the collaborative study for their suitability to serve as a reference reagent. The preparations were tested by 6 laboratories from 4 countries using\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    bioassays and also evaluated for thermal stability within the NIBSC laboratory. On the basis of the results of the collaborative study, both preparations, 07\/212 (NS0-derived) and 10\/176 (\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    -derived) were judged sufficiently active and stable to serve as a reference reagent. However, since IL-29 produced in\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    is in development for clinical applications, it was recommended that the preparation coded 10\/176 be established as the WHO international reference reagent for human IL-29. This recommendation was accepted, and the IL-29 preparation coded 10\/176 was formally established by the WHO ECBS at its meeting in October 2012 as the WHO international reference reagent for IL-29 with an assigned unitage of 5,000 reference units per ampoule.\n                  <\/jats:p>","DOI":"10.1089\/jir.2014.0015","type":"journal-article","created":{"date-parts":[[2014,6,23]],"date-time":"2014-06-23T14:29:01Z","timestamp":1403533741000},"page":"876-884","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Standardization of Human IL-29 (IFN-\u03bb1): Establishment of a World Health Organization International Reference Reagent for IL-29 (IFN-\u03bb1)"],"prefix":"10.1177","volume":"34","author":[{"given":"Anthony","family":"Meager","sequence":"first","affiliation":[{"name":"NIBSC, Medicines and Healthcare Products Regulatory Agency","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Heath","sequence":"additional","affiliation":[{"name":"NIBSC, Medicines and Healthcare Products Regulatory Agency","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Dilger","sequence":"additional","affiliation":[{"name":"NIBSC, Medicines and Healthcare Products Regulatory Agency","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Zoon","sequence":"additional","affiliation":[{"name":"National Institutes of Health"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meenu","family":"Wadhwa","sequence":"additional","affiliation":[{"name":"NIBSC, Medicines and Healthcare Products Regulatory Agency","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Participants of the Collaborative Study","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,11,1]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.01.018"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0812395"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044915"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2010.0078"},{"key":"e_1_3_3_6_1","unstructured":"Finney DJ. 1978. 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