{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T10:12:58Z","timestamp":1781604778880,"version":"3.54.5"},"reference-count":47,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Interferon &amp; Cytokine Research"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>\n                    B-lymphocyte activation is a common characteristic of chronic hepatitis B virus (HBV) infection. B cell-activating factor (BAFF) plays a crucial role in the development and activation of B lymphocytes. This study investigated serum BAFF levels in 232 patients with different clinical diseases of chronic HBV infection [33 chronic asymptomatic HBV carrier (ASC), 53 chronic hepatitis (CH), 72 liver cirrhosis (LC), and 74 hepatocellular carcinoma (HCC)] and 61 gender- and age-matched healthy controls. Serum BAFF levels in HBV patients were significantly elevated compared with healthy controls (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt;0.001). HCC patients had significantly higher levels of serum BAFF than ASC, CH, and LC (all\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt;0.001). Serum levels of BAFF in LC were significantly higher than in ASC (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt;0.001) and CH (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =0.002). Serum level of BAFF was an independent variable associated with the presence of HCC in comparison with other disease groups in multivariate analysis. The area under receiver-operating characteristic curve (AUC) value of BAFF levels was 0.914 for HCC versus ASC, 0.825 for HCC versus CH, and 0.607 for HCC versus LC, respectively. The AUC value of BAFF levels was 0.854 for LC versus ASC and 0.748 for LC versus CH, respectively. The AUC value of BAFF (0.888) for HCC was higher than that of alpha-fetoprotein (0.776). We first demonstrate that serum BAFF levels in chronic HBV infection are elevated, correlated with clinical diseases, and could be used as a biomarker for indicating disease mechanisms, activity, and diagnosis.\n                  <\/jats:p>","DOI":"10.1089\/jir.2014.0032","type":"journal-article","created":{"date-parts":[[2014,5,8]],"date-time":"2014-05-08T16:54:22Z","timestamp":1399568062000},"page":"787-794","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Serum Levels of B-Cell Activating Factor in Chronic Hepatitis B Virus Infection: Association with Clinical Diseases"],"prefix":"10.1177","volume":"34","author":[{"given":"Cuiling","family":"Yang","sequence":"first","affiliation":[{"name":"Xi'an Jiaotong University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[{"name":"Xi'an Jiaotong University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Wang","sequence":"additional","affiliation":[{"name":"Xi'an Jiaotong University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xi'an Jiaotong University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Zhu","sequence":"additional","affiliation":[{"name":"Xi'an Jiaotong University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Li","sequence":"additional","affiliation":[{"name":"Xi'an Jiaotong University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunying","family":"Han","sequence":"additional","affiliation":[{"name":"Xi'an Jiaotong University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lv","sequence":"additional","affiliation":[{"name":"Xi'an Jiaotong University","place":["China"]},{"name":"Xi'an Jiaotong University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Yu","sequence":"additional","affiliation":[{"name":"Xi'an Jiaotong University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wei","sequence":"additional","affiliation":[{"name":"Xi'an Jiaotong University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengwen","family":"Liu","sequence":"additional","affiliation":[{"name":"Xi'an Jiaotong University","place":["China"]},{"name":"Xi'an Jiaotong University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,10,1]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1007675"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.81920-0"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02844-06"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890310413"},{"key":"e_1_3_3_6_1","first-page":"472","article-title":"Diminished active T rosette levels and increased spontaneous B lymphocyte blastogenesis in hepatitis B virus positive chronic active hepatitis","volume":"52","author":"Budillon G","year":"1983","unstructured":"Budillon G, , Scala G, , D'Onofrio C, , Cassano S, , De Ritis F. 1983. 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Hepatitis B virus DNA in mononuclear blood cells. A frequent event in hepatitis B surface antigen-positive and -negative patients with acute and chronic liver disease. J Hepatol, 3:95\u2013103.","journal-title":"A frequent event in hepatitis B surface antigen-positive and -negative patients with acute and chronic liver disease. 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