{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:58:28Z","timestamp":1777701508145,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Interferon &amp; Cytokine Research"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p>\n                    The results of clinical and experimental studies suggest that type I interferons (IFNs) may have direct antifibrotic activity in addition to their antiviral properties. However, the mechanisms are still unclear; in particular, little is known about the antifibrotic activity of IFN-\u03b2 and how its activity is distinct from that of IFN-\u03b1. Using DNA microarrays, we demonstrated that gene expression in TWNT-4 cells, an activated human hepatic stellate cell line, was remarkably altered by IFN-\u03b2 more than by IFN-\u03b1. Integrated pathway enrichment analyses revealed that a variety of IFN-\u03b2\u2013mediated signaling pathways are uniquely regulated in TWNT-4 cells, including those related to cell cycle and Toll-like receptor 4 (TLR4) signaling. To investigate the antifibrotic activity of IFN-\u03b2 and the involvement of TLR4 signaling\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    , we used mice fed a choline-deficient\n                    <jats:sc>l<\/jats:sc>\n                    -amino acid-defined diet as a model of nonalcoholic steatohepatitis-related hepatic fibrosis. In this model, the administration of IFN-\u03b2 significantly attenuated augmentation of the area of liver fibrosis, with accompanying transcriptional downregulation of the TLR4 adaptor molecule MyD88. Our results provide important clues for understanding the mechanisms of the preferential antifibrotic activity of IFN-\u03b2 and suggest that IFN-\u03b2 itself, as well as being a modulator of its unique signaling pathway, may be a potential treatment for patients with hepatic fibrosis in a pathogenesis-independent manner.\n                  <\/jats:p>","DOI":"10.1089\/jir.2014.0096","type":"journal-article","created":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T16:58:46Z","timestamp":1424883526000},"page":"464-473","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Interferon-\u03b2 Mediates Signaling Pathways Uniquely Regulated in Hepatic Stellate Cells and Attenuates the Progression of Hepatic Fibrosis in a Dietary Mouse Model"],"prefix":"10.1177","volume":"35","author":[{"given":"Rieko","family":"Shimozono","sequence":"first","affiliation":[{"name":"Toray Industries, Inc.","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumi","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Toray Industries, Inc.","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Toray Industries, Inc.","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeko","family":"Funamoto","sequence":"additional","affiliation":[{"name":"Kamakura Techno-Science, Inc.","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Izawa","sequence":"additional","affiliation":[{"name":"Toray Industries, Inc.","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Sai","sequence":"additional","affiliation":[{"name":"Toray Industries, Inc.","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kana","family":"Kunita","sequence":"additional","affiliation":[{"name":"Toray Industries, Inc.","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mie","family":"Kainoh","sequence":"additional","affiliation":[{"name":"Toray Industries, Inc.","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiko","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Toray Industries, Inc.","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norifumi","family":"Kawada","sequence":"additional","affiliation":[{"name":"Osaka City University","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,6,1]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.13.3325"},{"issue":"3","key":"e_1_3_3_3_1","first-page":"175","article-title":"The impact of antiviral therapy on the course of chronic HCV infection","volume":"45","author":"Almasio PL","year":"2003","unstructured":"Almasio PL, , Venezia G, , Crax\u00ec A. 2003. The impact of antiviral therapy on the course of chronic HCV infection. A systematic review. Panminerva Med, 45(3):175\u2013182.","journal-title":"A systematic review. Panminerva Med"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24282"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.600783"},{"issue":"1","key":"e_1_3_3_6_1","first-page":"201","article-title":"Stronger growth-inhibitory effect of interferon (IFN)-beta compared to IFN-alpha is mediated by IFN signaling pathway in hepatocellular carcinoma cells","volume":"30","author":"Damdinsuren B","year":"2007","unstructured":"Damdinsuren B, , Nagano H, , Wada H, , Kondo M, , Ota H, , Nakamura M, , Noda T, , Natsag J, , Yamamoto H, , Doki Y, , Umeshita K, , Dono K, , Nakamori S, , Sakon M, , Monden M. 2007. Stronger growth-inhibitory effect of interferon (IFN)-beta compared to IFN-alpha is mediated by IFN signaling pathway in hepatocellular carcinoma cells. 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