{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:42:41Z","timestamp":1790358161316,"version":"4.1.0"},"reference-count":39,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Interferon &amp; Cytokine Research"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>Interleukin-17 (IL-17) has been proved to be involved in the pathogenesis of several autoimmune diseases, including lupus, rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease. The regulation of IL-17 signal transduction is less studied. miR-30a has been identified to be downregulated in these human autoimmune diseases and their related animal models. However, how it functions in IL-17-mediated inflammation and the pathogenesis of these diseases remain unknown. In this study, we showed that miR-30a inhibits IL-17-mediated NF-\u03baB and MAPK activation, leading to the reduced production of inflammatory cytokines and chemokines. miR-30a also reduced mRNA stability triggered by IL-17 stimulation. These suppressive effects of miR-30a were mediated by directly targeting Traf3ip2 mRNA (coding for Act1). Thus, we concluded that the downregulation of miR-30a in autoimmune diseases may exacerbate IL-17-mediated inflammation, which may serve as a potential target for the therapy of these diseases.<\/jats:p>","DOI":"10.1089\/jir.2014.0146","type":"journal-article","created":{"date-parts":[[2015,9,16]],"date-time":"2015-09-16T16:53:35Z","timestamp":1442422415000},"page":"917-923","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["The miR-30a Negatively Regulates IL-17-Mediated Signal Transduction by Targeting Traf3ip2"],"prefix":"10.1177","volume":"35","author":[{"given":"Qun","family":"Wan","sequence":"first","affiliation":[{"name":"Zhejiang University","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Zhou","sequence":"additional","affiliation":[{"name":"Zhejiang University","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiping","family":"Ding","sequence":"additional","affiliation":[{"name":"Zhejiang University","place":["People's Republic of China"]},{"name":"Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease","place":["People's Republic of China"]},{"name":"Zhejiang University","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqin","family":"He","sequence":"additional","affiliation":[{"name":"Zhejiang University","place":["People's Republic of China"]},{"name":"Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,11,1]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI36389"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0404432101"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061692"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e3283391feb"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61620-7"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0511155103"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2012.02.019"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr054344"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2586"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27334"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e3283373fa0"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2013.07.022"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.182.3.1660"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073909"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.08.018"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132710"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.26218"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.292pe64"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200011303432202"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37912"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.03.044"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2708"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06205"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1439"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071297"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-009-0186-z"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.889048"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1191\/0961203305lu2134oa"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2013.03.014"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2081"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.02.005"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210564"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200470"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-3311-T"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2427"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.9064"},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100703"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2815"}],"container-title":["Journal of Interferon &amp; Cytokine Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jir.2014.0146","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jir.2014.0146","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jir.2014.0146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:33:12Z","timestamp":1777455192000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jir.2014.0146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":39,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1089\/jir.2014.0146"],"URL":"https:\/\/doi.org\/10.1089\/jir.2014.0146","relation":{},"ISSN":["1079-9907","1557-7465"],"issn-type":[{"value":"1079-9907","type":"print"},{"value":"1557-7465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11]]}}}