{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:57:04Z","timestamp":1777701424206,"version":"3.51.4"},"reference-count":48,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Interferon &amp; Cytokine Research"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>\n                    We previously reported that\n                    <jats:italic toggle=\"yes\">Chlamydia muridarum<\/jats:italic>\n                    -infected murine oviduct epithelial cells (OE cells) secrete interferon \u03b2 (IFN-\u03b2) in a mostly TLR3-dependent manner. However,\n                    <jats:italic toggle=\"yes\">C. muridarum<\/jats:italic>\n                    -infected TLR3-deficient OE cells were still able to secrete detectable levels of IFN-\u03b2 into the supernatants, suggesting that other signaling pathways contribute to\n                    <jats:italic toggle=\"yes\">Chlamydia<\/jats:italic>\n                    -induced IFN-\u03b2 synthesis in these cells. We investigated the role of STAT1 as a possible contributor in the\n                    <jats:italic toggle=\"yes\">Chlamydia<\/jats:italic>\n                    -induced type-1 IFN production in wild-type (WT) and TLR3-deficient OE cells to ascertain its putative role at early- and late-times during\n                    <jats:italic toggle=\"yes\">Chlamydia<\/jats:italic>\n                    infection. Our data show that\n                    <jats:italic toggle=\"yes\">C. muridarum<\/jats:italic>\n                    infection significantly increased STAT1 gene expression and protein activation in WT OE cells; however, TLR3-deficient OE cells showed diminished STAT1 protein activation and gene expression. There was significantly less IFN-\u03b2 detected in the supernatants of\n                    <jats:italic toggle=\"yes\">C. muridarum<\/jats:italic>\n                    -infected OE cells derived from mice deficient in STAT1 when compared with WT OE cells, which suggest that STAT1 is required for the optimal synthesis of IFN-\u03b2 during infection. Real-time quantitative polymerase chain reaction analyses of signaling components of the type-1 IFN signaling pathway demonstrated equal upregulation in the expression of STAT2 and IRF7 genes in the WT and TLR3-deficient OE cells, but no upregulation in these genes in the STAT1-deficient OE cells. Finally, experiments in which INFAR1 was blocked with neutralizing antibody revealed that IFNAR1-mediated signaling was critical to the\n                    <jats:italic toggle=\"yes\">Chlamydia<\/jats:italic>\n                    -induced upregulation in IFN-\u03b1 gene transcription, but had no role in the\n                    <jats:italic toggle=\"yes\">Chlamydia<\/jats:italic>\n                    -induced upregulation in IFN-\u03b2 gene transcription.\n                  <\/jats:p>","DOI":"10.1089\/jir.2015.0013","type":"journal-article","created":{"date-parts":[[2015,8,11]],"date-time":"2015-08-11T14:17:43Z","timestamp":1439302663000},"page":"901-916","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Role of STAT1 in\n                    <i>Chlamydia<\/i>\n                    -Induced Type-1 Interferon Production in Oviduct Epithelial Cells"],"prefix":"10.1177","volume":"35","author":[{"given":"Kristen Lynette","family":"Hosey","sequence":"first","affiliation":[{"name":"Indiana University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sishun","family":"Hu","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine"},{"name":"Huazhong Agricultural University","place":["People's Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilbert Alfred","family":"Derbigny","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,11,1]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2009.07.001"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00316-07"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095076"},{"issue":"23","key":"e_1_3_3_5_1","first-page":"3164","article-title":"The association between Chlamydia trachomatis and ectopic pregnancy","volume":"263","author":"Chow JM","year":"1990","unstructured":"Chow JM, , Yonekura ML, , Richwald GA, , Greenland S, , Sweet RL, , Schachter J. 1990. The association between Chlamydia trachomatis and ectopic pregnancy. A matched-pair, case-control study. JAMA, 263(23):3164\u20133167.","journal-title":"A matched-pair, case-control study. 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Comparison of multiple genital tract infections with Chlamydia trachomatis in different strains of female mice. J Microbiol Immunol Infect, 38(6):383\u2013393.","journal-title":"J Microbiol Immunol Infect"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.22.6660"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.18.2229"},{"issue":"6","key":"e_1_3_3_30_1","first-page":"422","article-title":"Chlamydia trachomatis infection of the fallopian tubes. Histological findings in two patients","volume":"55","author":"Moller BR","year":"1979","unstructured":"Moller BR, , Westrom L, , Ahrons S, , Ripa KT, , Svensson L, , von Mecklenburg C, , Henrikson H, , Mardh PA. 1979. Chlamydia trachomatis infection of the fallopian tubes. Histological findings in two patients. 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