{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:57:17Z","timestamp":1777701437030,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Interferon &amp; Cytokine Research"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>\n                    To understand the role of interferon (IFN)-\u03b3 gene (\n                    <jats:italic toggle=\"yes\">IFNG<\/jats:italic>\n                    ) single-nucleotide polymorphisms (SNPs) in the resistance to H5N1 highly pathogenic avian influenza (HPAI), we determined the SNPs, the log\n                    <jats:sub>2<\/jats:sub>\n                    -transformed specific antibody titers, and\n                    <jats:italic toggle=\"yes\">ex vivo<\/jats:italic>\n                    recall antigen-specific IFN-\u03b3 production by peripheral blood mononuclear cells (PBMCs) in 62 red junglefowls (\n                    <jats:italic toggle=\"yes\">Gallus gallus<\/jats:italic>\n                    ) immunized twice with inactivated H5N1 HPAI vaccine. Consequently, 52 SNPs were detected in the amplified 1137-bp length covering the promoter region and all exons, with +2133A\/T SNP in the coding DNA sequence that caused a missense mutation and was identified in\n                    <jats:italic toggle=\"yes\">G. gallus<\/jats:italic>\n                    for the first time. For \u2212316A\/G SNP genotypes, the chi-squared test showed that the bird sample was in the Hardy\u2013Weinberg equilibrium (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =0.369&gt;0.05), and the least squares analysis revealed an increasing tendency in the antibody titers with G to A substitution so that a significant difference occurred between the AA genotype (8.031\u00b10.247) and the GG genotype (6.571\u00b10.528) (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =0.015&lt;0.05, 95% confidence interval [CI]: 0.0004\u20130.0866), as basically consistent with the antigen-induced IFN-\u03b3 protein expression, which indicated possible association of the \u2212316A\/G SNP with a secondary humoral immune response to the HPAI vaccine in the bird population. These findings may help to improve genetic resistance using cross-breeding and enhance HPAI vaccine-induced immunity in chicken production.\n                  <\/jats:p>","DOI":"10.1089\/jir.2015.0018","type":"journal-article","created":{"date-parts":[[2015,7,8]],"date-time":"2015-07-08T11:49:12Z","timestamp":1436356152000},"page":"844-849","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Possible Association of IFN-\u03b3 Gene \u2212316A\/G SNP with Humoral Immune Response to Killed H5N1 HPAI Vaccine in a Red Junglefowl Population"],"prefix":"10.1177","volume":"35","author":[{"given":"Bin","family":"Ji","sequence":"first","affiliation":[{"name":"Yunnan Agricultural University","place":["People's Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Ting","family":"Sun","sequence":"additional","affiliation":[{"name":"Yunnan Agricultural University","place":["People's Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Liang","family":"Ma","sequence":"additional","affiliation":[{"name":"Yunnan Agricultural University","place":["People's Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong-Fen","family":"Lu","sequence":"additional","affiliation":[{"name":"Yunnan Agricultural University","place":["People's Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Li","family":"Hu","sequence":"additional","affiliation":[{"name":"Yunnan Agricultural University","place":["People's Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zong-Hui","family":"Jian","sequence":"additional","affiliation":[{"name":"Yunnan Agricultural University","place":["People's Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Yunnan Agricultural University","place":["People's Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-Fu","family":"Chen","sequence":"additional","affiliation":[{"name":"Yunnan Agricultural University","place":["People's Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,11,1]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2007.00722.x"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.70.7.4411-4418.1996"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/18.18.5481"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.8.6637-6645.1998"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/129.2.328"},{"issue":"2","key":"e_1_3_3_7_1","first-page":"145","article-title":"Enhancement of Th1 immune responses to recombinant influenza nucleoprotein by Ribi adjuvant","volume":"36","author":"Cargnelutti DE","year":"2013","unstructured":"Cargnelutti DE, , Sanchez MA, , Alvarez P, , Boado L, , Mattion N, , Scodeller EA. 2013. Enhancement of Th1 immune responses to recombinant influenza nucleoprotein by Ribi adjuvant. New Microbiol, 36(2):145\u2013151.","journal-title":"New Microbiol"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.56.082103.104540"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1503.081410"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-009-0359-x"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103474"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007772"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.05204-11"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8456301"},{"key":"e_1_3_3_15_1","first-page":"57","article-title":"Integrated immunogenomics in the chicken: deciphering the immune response to identify disease resistance genes","volume":"132","author":"Kaiser P","year":"2008","unstructured":"Kaiser P, , Howell J, , Fife M, , Sadeyen JR, , Salmon N, , Rothwell L, , Young J, , van Diemen P, , Stevens M, , Poh TY, , Jones M, , Barrow P, , Swaggerty C, , Kogut M, , Smith J, , Burt D. 2008. Integrated immunogenomics in the chicken: deciphering the immune response to identify disease resistance genes. Dev Biol (Basel), 132:57\u201366.","journal-title":"Dev Biol (Basel)"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(97)00600-8"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2010.0069"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.8.1541"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/0307945042000220318"},{"key":"e_1_3_3_20_1","unstructured":"Lamont SJ. 2002. Candidate genes for immune response and disease resistance in chickens. Available at www.poultryscience.org\/docs\/pba\/1952\u20132003\/2002\/2002%20Lamont.pdf (accessed 24. 12.2014)."},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0882-4010(02)00191-2"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1297-9716-42-84"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02423-13"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1004879107"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02135-09"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01776-13"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031953"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1998.1314"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.153.3.1246"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010639"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0603252"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.10.4886-4890.2002"},{"issue":"1","key":"e_1_3_3_33_1","first-page":"36","article-title":"Viral specific CD8+T lymphocyte immunity provides protection against heterotypic stains of avian influenza viruses and avian coronaviruses","volume":"2","author":"Singh S","year":"2014","unstructured":"Singh S, , Pei J, , Collisson EW. 2014. Viral specific CD8+T lymphocyte immunity provides protection against heterotypic stains of avian influenza viruses and avian coronaviruses. Int Trends Immun, 2(1):36\u201346.","journal-title":"Int Trends Immun"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2010.05.002"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.12-0433"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2012.11.012"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2009.0084"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/ps\/85.9.1555"},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/ps\/80.12.1679"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1637\/0005-2086(2002)046[0869:AOIGAP]2.0.CO;2"}],"container-title":["Journal of Interferon &amp; Cytokine Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jir.2015.0018","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jir.2015.0018","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jir.2015.0018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:33:14Z","timestamp":1777455194000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jir.2015.0018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":39,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1089\/jir.2015.0018"],"URL":"https:\/\/doi.org\/10.1089\/jir.2015.0018","relation":{},"ISSN":["1079-9907","1557-7465"],"issn-type":[{"value":"1079-9907","type":"print"},{"value":"1557-7465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11]]}}}