{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:08:06Z","timestamp":1790298486441,"version":"4.1.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Interferon &amp; Cytokine Research"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:p>\n                    Despite the fact that\n                    <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                    is an important human fungal pathogen and Dectin-2 is a major pattern recognition receptor for fungi, our knowledge regarding the role of Dectin-2 for the host defense against disseminated candidiasis is limited. Dectin-2 deficient (Dectin-2\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) mice were more susceptible to systemic candidiasis, and the susceptibility was mirrored by an elevated fungal load in the kidneys that correlated with the presence of large inflammatory foci. Phagocytosis of\n                    <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                    by the macrophages lacking the Dectin-2 receptor was moderately decreased, while production of most of the macrophage-derived cytokines from Dectin-2\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice with systemic candidiasis was decreased. No striking differences among several\n                    <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                    mutants defective in mannans could be detected between na\u00efve wild-type and Dectin-2\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice, apart from the \u03b2-mannan-deficient\n                    <jats:italic toggle=\"yes\">bmt1<\/jats:italic>\n                    \u0394\n                    <jats:italic toggle=\"yes\">\/bmt2<\/jats:italic>\n                    \u0394\n                    <jats:italic toggle=\"yes\">\/bmt5<\/jats:italic>\n                    \u0394 triple mutant, suggesting that \u03b2-mannan may partially mask \u03b1-mannan detection, which is the major fungal structure recognized by Dectin-2. Deciphering the mechanisms responsible for host defense against the majority of\n                    <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                    strains represents an important step in understanding the pathophysiology of systemic candidiasis, which might lead to the development of novel immunotherapeutic strategies.\n                  <\/jats:p>","DOI":"10.1089\/jir.2015.0040","type":"journal-article","created":{"date-parts":[[2016,4,5]],"date-time":"2016-04-05T15:51:01Z","timestamp":1459871461000},"page":"267-276","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":57,"title":["The Role of Dectin-2 for Host Defense Against Disseminated Candidiasis"],"prefix":"10.1177","volume":"36","author":[{"given":"Daniela C.","family":"Ifrim","sequence":"first","affiliation":[{"name":"Radboud University Nijmegen Medical Centre","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Quintin","sequence":"additional","affiliation":[{"name":"Radboud University Nijmegen Medical Centre","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavie","family":"Courjol","sequence":"additional","affiliation":[{"name":"Inserm U995","place":["France"]},{"name":"Universit\u00e9 de Lille","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ineke","family":"Verschueren","sequence":"additional","affiliation":[{"name":"Radboud University Nijmegen Medical Centre","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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