{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T11:49:43Z","timestamp":1789904983497,"version":"4.0.1"},"reference-count":32,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T00:00:00Z","timestamp":1454976000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Interferon &amp; Cytokine Research"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p>\n                    Despite the appearance of new oral antiviral drugs, pegylated interferon (PEG-IFN)\/RBV may remain the standard of care therapy for some time, and several viral and host factors are reported to be correlated with therapeutic effects. This study aimed to reveal the independent variables associated with failure of sustained virological response (SVR) to PEG-IFN alpha-2a versus PEG-IFN alpha-2b in treatment of naive chronic hepatitis C virus (HCV) Egyptian patients using both statistical methods and data mining techniques. This retrospective cohort study included 3,235 chronic hepatitis C patients enrolled in a large Egyptian medical center: 1,728 patients had been treated with PEG-IFN alpha-2a plus ribavirin (RBV) and 1,507 patients with PEG-IFN alpha-2b plus RBV between 2007 and 2011. Both multivariate analysis and Reduced Error Pruning Tree (REPTree)-based model were used to reveal the independent variables associated with treatment response. In both treatment types, alpha-fetoprotein (AFP) &gt;10\u2009ng\/mL and HCV viremia &gt;600\u2009\u00d7\u200910\n                    <jats:sup>3<\/jats:sup>\n                    IU\/mL were the independent baseline variables associated with failure of SVR, while male gender, decreased hemoglobin, and thyroid-stimulating hormone were the independent variables associated with good response (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u20090.05). Using REPTree-based model showed that low AFP was the factor of initial split (best predictor) of response for either PEG-IFN alpha-2a or PEG-IFN alpha-2b (cutoff value 8.53, 4.89\u2009ng\/mL, AUROC\u2009=\u20090.68 and 0.61,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.05). Serum AFP &gt;10\u2009ng\/mL and viral load &gt;600\u2009\u00d7\u200910\n                    <jats:sup>3<\/jats:sup>\n                    IU\/mL are variables associated with failure of response in both treatment types. REPTree-based model could be used to assess predictors of response.\n                  <\/jats:p>","DOI":"10.1089\/jir.2015.0141","type":"journal-article","created":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T15:39:50Z","timestamp":1455032390000},"page":"338-346","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Predictors of Virological Response in 3,235 Chronic HCV Egyptian Patients Treated with Peginterferon Alpha-2a Compared with Peginterferon Alpha-2b Using Statistical Methods and Data Mining Techniques"],"prefix":"10.1177","volume":"36","author":[{"given":"Maissa","family":"El Raziky","sequence":"first","affiliation":[{"name":"Cairo University","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed Fouad","family":"Fathalah","sequence":"additional","affiliation":[{"name":"Cairo University","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab","family":"Zakaria","sequence":"additional","affiliation":[{"name":"Cairo University","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadeel Gamal","family":"Eldeen","sequence":"additional","affiliation":[{"name":"Cairo University","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr","family":"Abul-Fotouh","sequence":"additional","affiliation":[{"name":"Cairo University","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Salama","sequence":"additional","affiliation":[{"name":"Cairo University","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abubakr","family":"Awad","sequence":"additional","affiliation":[{"name":"Cairo University","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamal","family":"Esmat","sequence":"additional","affiliation":[{"name":"Cairo University","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahasen","family":"Mabrouk","sequence":"additional","affiliation":[{"name":"Cairo University","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,2,9]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0256-4947.51810"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.10.005"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.078147"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000063219.21313.32"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510240201"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.02.015"},{"key":"e_1_3_3_8_1","unstructured":"Breiman L Friedman R Olshen C Stone C. 1980. 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Impact of serum alpha-fetoprotein levels on the response to antiviral therapy in Egyptian patients with chronic hepatitis C. J Gastroenterol Hepatol Res, 12(5):597\u2013601.","journal-title":"J Gastroenterol Hepatol Res"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/135965350701200506"},{"issue":"6","key":"e_1_3_3_20_1","first-page":"347","article-title":"Frequency of thyroid disorders during interferon and ribavirin therapy in chronic hepatitis C infection","volume":"18","author":"Masood N","year":"2008","unstructured":"Masood N, , Ghori R, , Memon A, , Memon S, , Memon KI, , Memon I, , Jaffri M, , Baloch GH. 2008. Frequency of thyroid disorders during interferon and ribavirin therapy in chronic hepatitis C infection. 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Low serum alpha-fetoprotein level an important predictor for therapeutic outcome in Egyptian patients with chronic hepatitis C: a data-mining analysis. J Gastrointest Dig Syst, 4(6):240.","journal-title":"J Gastrointest Dig Syst"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2012.09.005"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200409000-00013"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.10.003"}],"container-title":["Journal of Interferon &amp; Cytokine Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jir.2015.0141","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jir.2015.0141","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jir.2015.0141","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T21:17:58Z","timestamp":1781558278000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jir.2015.0141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,9]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1089\/jir.2015.0141"],"URL":"https:\/\/doi.org\/10.1089\/jir.2015.0141","relation":{},"ISSN":["1079-9907","1557-7465"],"issn-type":[{"value":"1079-9907","type":"print"},{"value":"1557-7465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,9]]}}}