{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:34:17Z","timestamp":1791423257238,"version":"4.3.3"},"reference-count":44,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Interferon &amp; Cytokine Research"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">2\u2032-5\u2032-oligoadenylate synthetase-like<\/jats:italic>\n                    (OASL) is a kind of antiviral protein induced by interferons (IFNs), which plays an important role in the IFNs-mediated antiviral signaling pathway. In this study, we cloned and identified OASL in the Chinese goose for the first time. Goose\n                    <jats:italic toggle=\"yes\">2\u2032-5\u2032-oligoadenylate synthetase-like<\/jats:italic>\n                    (\n                    <jats:italic toggle=\"yes\">go<\/jats:italic>\n                    OASL), including an ORF of 1527bp, encoding a protein of 508 amino acids.\n                    <jats:italic toggle=\"yes\">Go<\/jats:italic>\n                    OASL protein contains 3 conserved motifs: nucleotidyltransferase (NTase) domain, 2\u2032-5\u2032-oligoadenylate synthetase (OAS) domain, and 2 ubiquitin-like (UBL) repeats. The tissue distribution profile of\n                    <jats:italic toggle=\"yes\">go<\/jats:italic>\n                    OASL in 2-week-old gosling and adult goose were identified by Real-Time quantitative PCR, which revealed that the highest level of\n                    <jats:italic toggle=\"yes\">go<\/jats:italic>\n                    OASL mRNA transcription was detected in the blood of adult goose and gosling. The mRNA transcription level of\n                    <jats:italic toggle=\"yes\">go<\/jats:italic>\n                    OASL was upregulated in all tested tissues of duck Tembusu virus (DTMUV)-infected 3-day-old goslings, compared with control groups. Furthermore, using the stimulus Poly(I: C), ODN2006, R848, and lipopolysaccharide (LPS) as well as the viral pathogens DTMUV, H9N2 avian influenza virus (AIV), and gosling plague virus (GPV) to treat goose peripheral blood mononuclear cells (PBMCs) for 6\u2009h,\n                    <jats:italic toggle=\"yes\">go<\/jats:italic>\n                    OASL transcripts level was significantly upregulated in all treated groups. To further investigate the antiviral activity of\n                    <jats:italic toggle=\"yes\">go<\/jats:italic>\n                    OASL, pcDNA3.1(+)-\n                    <jats:italic toggle=\"yes\">go<\/jats:italic>\n                    OASL-His plasmid was constructed, and\n                    <jats:italic toggle=\"yes\">go<\/jats:italic>\n                    OASL was expressed by the goose embryo fibroblast cells (GEFs) transfected with pcDNA3.1(+)-\n                    <jats:italic toggle=\"yes\">go<\/jats:italic>\n                    OASL-His. Our research data suggested that Newcastle disease virus (NDV) replication (viral copies and viral titer) in GEFs was significantly reduced by the overexpression of\n                    <jats:italic toggle=\"yes\">go<\/jats:italic>\n                    OASL protein. These data were meaningful for the antiviral immunity research of goose and shed light on the future prevention of NDV in fowl.\n                  <\/jats:p>","DOI":"10.1089\/jir.2015.0167","type":"journal-article","created":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T16:07:17Z","timestamp":1472573237000},"page":"563-572","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["Identification of\n                    <i>2\u2032-5\u2032-Oligoadenylate Synthetase-Like<\/i>\n                    Gene in Goose: Gene Structure, Expression Patterns, and Antiviral Activity Against Newcastle Disease Virus"],"prefix":"10.1177","volume":"36","author":[{"given":"Chao","family":"Yang","sequence":"first","affiliation":[{"name":"Sichuan Agricultural University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Liu","sequence":"additional","affiliation":[{"name":"Sichuan Agricultural University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Chen","sequence":"additional","affiliation":[{"name":"Sichuan Agricultural University","place":["China"]},{"name":"Sichuan Agricultural University","place":["China"]},{"name":"Sichuan Agricultural University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingshu","family":"Wang","sequence":"additional","affiliation":[{"name":"Sichuan Agricultural University","place":["China"]},{"name":"Sichuan Agricultural University","place":["China"]},{"name":"Sichuan Agricultural University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renyong","family":"Jia","sequence":"additional","affiliation":[{"name":"Sichuan Agricultural University","place":["China"]},{"name":"Sichuan Agricultural University","place":["China"]},{"name":"Sichuan Agricultural University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dekang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Sichuan Agricultural University","place":["China"]},{"name":"Sichuan Agricultural University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mafeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Sichuan Agricultural University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunfeng","family":"Sun","sequence":"additional","affiliation":[{"name":"Sichuan Agricultural University","place":["China"]},{"name":"Sichuan Agricultural University","place":["China"]},{"name":"Sichuan Agricultural University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Sichuan Agricultural University","place":["China"]},{"name":"Sichuan Agricultural 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