{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:45:50Z","timestamp":1788965150272,"version":"build-2803163510"},"reference-count":38,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Interferon &amp; Cytokine Research"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>\n                    A mix of flavonoids comprising baicalin (BA) and catechin showed effective impacts on controlling the progress of knee osteoarthritis (OA). However, little is known about the underlying mechanisms. The influences of BA on the transcriptional levels of a series of proinflammatory genes were measured using real-time reverse transcription and polymerase chain reaction (RT-PCR). The expressions of proteins involved in nuclear factor-\u03baB (NF-\u03baB) activation were detected by Western blot. The\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    results were confirmed in a mouse OA model. We found that BA treatment led to remarkable reductions of OA-related proinflammatory gene expressions, including interleukin (IL)-6, tumor necrosis factor (TNF), chemokine (C-X-C motif) ligand 1 (CXCL1), and CXCL10. The transcriptional levels of inducible nitric oxide synthase (iNOS\/Nos2), matrix metalloproteinases (MMP)3, and MMP13 were significantly inhibited by BA. We measured the productions of nitrite and prostaglandin E\n                    <jats:sub>2<\/jats:sub>\n                    from human chondrocytes and BA was shown to reduce their productions. On the contrary, mRNA levels of aggrecan and collagen-II were enhanced by BA treatment. The inhibitory role of BA on OA may possibly be mediated by NF-\u03baB signaling because of comparable decreases of phosphorylated (p)-p65 and p-I\u03baB\u03b1 and less p65 translocation in the nucleus after BA treatment. In OA mice model, BA significantly reduced synovitis scores and related gene expressions, including IL-6, TNF, CXCL1, CXCL10, MMP3, MMP13, and Nos2. In conclusion, BA suppresses the inflammatory responses of human chondrocytes to IL-1\u03b2 stimulation, and NF-\u03baB signaling may be involved in the mechanisms of BA functions.\n                  <\/jats:p>","DOI":"10.1089\/jir.2017.0030","type":"journal-article","created":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T10:26:47Z","timestamp":1503397607000},"page":"398-405","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Baicalin Inhibits Inflammatory Responses to Interleukin-1\u03b2 Stimulation in Human Chondrocytes"],"prefix":"10.1177","volume":"37","author":[{"given":"Deguo","family":"Xing","sequence":"first","affiliation":[{"name":"The Second Hospital of Shandong University","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Gao","sequence":"additional","affiliation":[{"name":"The Second Hospital of Shandong University","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghao","family":"Liu","sequence":"additional","affiliation":[{"name":"The Second Hospital of Shandong University","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Second Hospital of Shandong University","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhi","family":"Gong","sequence":"additional","affiliation":[{"name":"The Second Hospital of Shandong University","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,9]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00322.x"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096925"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.2741\/e361"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000143805.64755.4f"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/385780"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.04.042"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X17500100"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2014.12.065"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.080346"},{"issue":"11","key":"e_1_3_3_11_1","first-page":"2444","article-title":"Celecoxib has a positive effect on the overall metabolism of hyaluronan human osteoarthritic and proteoglycans in cartilage","volume":"30","author":"El Hajjaji H","year":"2003","unstructured":"El Hajjaji H, , Marcelis A, , Devogelaer JP, , Manicourt DH. 2003. 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