{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T06:04:24Z","timestamp":1777701864115,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Interferon &amp; Cytokine Research"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Helicobacter pylori<\/jats:italic>\n                    is a ubiquitous Gram-negative bacterium, that is responsible for gastric mucosal inflammation. It is the most common risk factor for gastric cancer (GC). The current study aimed to investigate the association between interleukin-11 (IL-11) and leukemia inhibitory factor (LIF) levels among\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    -infected Egyptian patients with gastritis and GC. One hundred forty-seven patients with gastric lesions were endoscopically biopsied and assessed using rapid urease test and immunohistochemistry. Quantitative real-time polymerase chain reaction was done for the detection of\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    load in gastric biopsies and detection of LIF as well as IL-11 relative gene expression. The mean values of\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    load, LIF, and IL-11 were significantly elevated in GC patients compared to gastritis group (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u20090.0001). A positive significant correlation was detected between mucosal levels of LIF, IL-11, and\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    load in both groups. Both LIF and IL-11 had the same pattern of expression in gastric tissues with different types of gastritis and different types and grades of gastric carcinoma. This report could clarify the molecular events associated with the immune response against\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    infection and\n                    <jats:italic toggle=\"yes\">H. pylori-<\/jats:italic>\n                    associated pathology. Therefore, development of immunotherapy strategies against\n                    <jats:italic toggle=\"yes\">H. pylori-<\/jats:italic>\n                    induced cytokines becomes inevitable.\n                  <\/jats:p>","DOI":"10.1089\/jir.2018.0065","type":"journal-article","created":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T16:33:13Z","timestamp":1541089993000},"page":"517-525","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Interplay Between\n                    <i>Helicobacter pylori<\/i>\n                    Infection, Interleukin-11, and Leukemia Inhibitory Factor in Gastric Cancer Among Egyptian Patients"],"prefix":"10.1177","volume":"38","author":[{"given":"Dina","family":"Sabry","sequence":"first","affiliation":[{"name":"Cairo University","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omayma O.","family":"Abdelaleem","sequence":"additional","affiliation":[{"name":"Fayoum University","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enas M.","family":"Hefzy","sequence":"additional","affiliation":[{"name":"Fayoum University","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal A.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Fayoum University","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarek I.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Fayoum University","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Essam A.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Fayoum University","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nehal D.","family":"Abdel-Hameed","sequence":"additional","affiliation":[{"name":"Cairo University","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud A.F.","family":"Khalil","sequence":"additional","affiliation":[{"name":"Fayoum University","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,12,5]]},"reference":[{"issue":"2","key":"e_1_3_3_2_1","first-page":"123","article-title":"Normalized real-time PCR for diagnosis of H","volume":"2014","author":"Al-Moayad EE","year":"2014","unstructured":"Al-Moayad EE, , Alghalibi SM, , Al-Shamahy HA, , Nasher AT, , Al-Hebshi NN. 2014. Normalized real-time PCR for diagnosis of H. pylori infection. Qatar Med J, 2014(2):123\u2013129.","journal-title":"pylori infection. Qatar Med J"},{"issue":"13","key":"e_1_3_3_3_1","first-page":"3554","article-title":"A human model of gastric carcinogenesis","volume":"48","author":"Correa P","year":"1988","unstructured":"Correa P. 1988. A human model of gastric carcinogenesis. 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